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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2019

Open Access 01-12-2019 | Obesity | Review

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential

A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation

Authors: Jean-Charles Fruchart, Raul D. Santos, Carlos Aguilar-Salinas, Masanori Aikawa, Khalid Al Rasadi, Pierre Amarenco, Philip J. Barter, Richard Ceska, Alberto Corsini, Jean-Pierre Després, Patrick Duriez, Robert H. Eckel, Marat V. Ezhov, Michel Farnier, Henry N. Ginsberg, Michel P. Hermans, Shun Ishibashi, Fredrik Karpe, Tatsuhiko Kodama, Wolfgang Koenig, Michel Krempf, Soo Lim, Alberto J. Lorenzatti, Ruth McPherson, Jesus Millan Nuñez-Cortes, Børge G. Nordestgaard, Hisao Ogawa, Chris J. Packard, Jorge Plutzky, Carlos I. Ponte-Negretti, Aruna Pradhan, Kausik K. Ray, Željko Reiner, Paul M. Ridker, Massimiliano Ruscica, Shaukat Sadikot, Hitoshi Shimano, Piyamitr Sritara, Jane K. Stock, Ta-Chen Su, Andrey V. Susekov, André Tartar, Marja-Riitta Taskinen, Alexander Tenenbaum, Lale S. Tokgözoğlu, Brian Tomlinson, Anne Tybjærg-Hansen, Paul Valensi, Michal Vrablík, Walter Wahli, Gerald F. Watts, Shizuya Yamashita, Koutaro Yokote, Alberto Zambon, Peter Libby

Published in: Cardiovascular Diabetology | Issue 1/2019

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Abstract

In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk.
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Metadata
Title
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation
Authors
Jean-Charles Fruchart
Raul D. Santos
Carlos Aguilar-Salinas
Masanori Aikawa
Khalid Al Rasadi
Pierre Amarenco
Philip J. Barter
Richard Ceska
Alberto Corsini
Jean-Pierre Després
Patrick Duriez
Robert H. Eckel
Marat V. Ezhov
Michel Farnier
Henry N. Ginsberg
Michel P. Hermans
Shun Ishibashi
Fredrik Karpe
Tatsuhiko Kodama
Wolfgang Koenig
Michel Krempf
Soo Lim
Alberto J. Lorenzatti
Ruth McPherson
Jesus Millan Nuñez-Cortes
Børge G. Nordestgaard
Hisao Ogawa
Chris J. Packard
Jorge Plutzky
Carlos I. Ponte-Negretti
Aruna Pradhan
Kausik K. Ray
Željko Reiner
Paul M. Ridker
Massimiliano Ruscica
Shaukat Sadikot
Hitoshi Shimano
Piyamitr Sritara
Jane K. Stock
Ta-Chen Su
Andrey V. Susekov
André Tartar
Marja-Riitta Taskinen
Alexander Tenenbaum
Lale S. Tokgözoğlu
Brian Tomlinson
Anne Tybjærg-Hansen
Paul Valensi
Michal Vrablík
Walter Wahli
Gerald F. Watts
Shizuya Yamashita
Koutaro Yokote
Alberto Zambon
Peter Libby
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2019
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-019-0864-7

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