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Respiratory Research

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Open Access 01-12-2022 | Mites | Research

Assessing the impact of air pollutants on clinical visits for childhood allergic respiratory disease induced by house dust mite in Shanghai, China

Authors: Junyang Li, Yabin Hu, Huaiyuan Li, Yihang Lin, Shilu Tong, Youjin Li

Published in: Respiratory Research | Issue 1/2022

Abstract

Background

The prevalence of allergic respiratory disease (ARD) is increasing worldwide during the last few decades, causing a great disease burden especially for children. Air pollution has been increasingly considered as a potential contributor to this trend, but its role in ARD induced by house dust mite (HDM-ARD) remains unclear, especially in time-series study.

Methods

A positive reporting of respiratory allergy to named allergens was included by serum specific IgE testing. A time series Quasi-Poisson regression with distributed lag non-linear model, combined with generalized linear model was used to examine the effects of air pollutants on ARD, HDM-ARD and ARD induced by non-house dust mite (NHDM-ARD).

Results

A total of 16,249 cases of ARD, including 8,719 HDM-ARD and 8,070 NHDM-ARD from 1 Jan 2013 to 31 Dec 2017 were involved in this study. Air pollutants were significantly associated with clinical visits for childhood ARD and HDM-ARD. Exposure to higher O₃ and interquartile range (IQR) increment in O₃ (40.6 µg/m³) increased the risks of clinical visits for childhood HDM-ARD (RR_lag0-5 for the 95th percentile of O₃: 1.26, 95% confidence interval (CI): 1.03, 1.55; RR_lag0-5 for IQR increment (40.6 µg/m³): 1.09, 95% CI: 1.01, 1.17) and ARD (RR_lag0-5 for the 95th percentile of O₃: 1.19, 95% CI: 1.03, 1.38; RR_lag0-5 for IQR increment (40.6 µg/m³): 1.06, 95% CI: 1.01, 1.12). In addition, higher O₃ was associated with increased RR of boys with ARD (RR_lag0-5 for the 95th percentile: 1.26, 95% CI: 1.05, 1.51; RR_lag0-5 for IQR increment (40.6 µg/m³): 1.09, 95% CI: 1.02, 1.16) and HDM-ARD (RR_lag0-5 for the 95th percentile: 1.36, 95% CI: 1.06, 1.75; RR_lag0-5 for IQR increment (40.6 µg/m³): 1.11, 95% CI: 1.02, 1.22), but not in girls.

Conclusions

Exposure to O₃ appeared to be a trigger of clinical visits for childhood ARD, especially for HDM-ARD and boys. These findings provide novel evidence on the impact of air pollution on HDM-ARD, which may have significant implications for designing effective intervention programs to control and prevent childhood ARD, especially HDM-ARD, in China and other similar developing countries.

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Title: Assessing the impact of air pollutants on clinical visits for childhood allergic respiratory disease induced by house dust mite in Shanghai, China
Authors: Junyang Li
Yabin Hu
Huaiyuan Li
Yihang Lin
Shilu Tong
Youjin Li
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Mites
Air Pollutants
Published in: Respiratory Research / Issue 1/2022
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-022-01967-1

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Conclusions

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