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Respiratory Research
Published in: Respiratory Research 1/2020

01-12-2020 | Underweight | Research

Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial

Authors: Afsane Ahmadi, Mohammad Hassan Eftekhari, Zohreh Mazloom, Masoom Masoompour, Mohammad Fararooei, Mohammad Hadi Eskandari, Samrad Mehrabi, Alireza Bedeltavana, Mandana Famouri, Morteza Zare, Nasrin Nasimi, Zahra Sohrabi

Published in: Respiratory Research | Issue 1/2020

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Abstract

Background

The development of effective nutritional supports for patients with chronic obstructive pulmonary diseases (COPD) is still challenging. This study was conducted to investigate the efficacy of daily consumption of fortified whey on inflammation, muscle mass, functionality, and quality of life in patients with moderate-to-severe COPD.

Methods

A single-blind, randomized trial study was performed on patients with COPD (n = 46). Participants in the intervention group (n = 23) daily received 250 ml of whey beverage fortified with magnesium and vitamin C for 8 weeks. Any changes in inflammatory cytokines (including interleukin- 6 (IL-6) and tumor necrosis factor (TNFα)) were the primary outcomes and the secondary outcomes were fat-free mass, handgrip strength, malnutrition, glutathione and malondialdehyde serum concentrations, and health-related quality of life (HRQoL). Body composition and muscle strength were measured by Bioelectrical Impedance Analysis (BIA) and hydraulic hand dynamometer, respectively. Fat-free mass index (FFMI) was also calculated.

Results

At the end of the study, 44 patients were analyzed. There were significant decreases in IL-6 concentrations in the intervention group compared to the control group. Also, FFMI, body protein, and handgrip strength increased significantly in the intervention group with significant changes between two groups. Moreover, improvement in health-related quality of life was observed in the intervention group compared to the control group. There were no significant changes in other study variables.

Conclusions

This novel nutritional intervention decreased inflammatory cytokines levels, improved indices of skeletal muscle mass and muscle strength, and ultimately, increased HRQoL in patients with moderate-to-severe COPD. Thus, it is suggested to do further studies to assess the effects of nutrition intervention on COPD progression.

Trial registration

IR.SUMS.REC.1396.85 (https://​www.​irct.​ir/​).
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Metadata
Title
Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial
Authors
Afsane Ahmadi
Mohammad Hassan Eftekhari
Zohreh Mazloom
Masoom Masoompour
Mohammad Fararooei
Mohammad Hadi Eskandari
Samrad Mehrabi
Alireza Bedeltavana
Mandana Famouri
Morteza Zare
Nasrin Nasimi
Zahra Sohrabi
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2020
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-020-01466-1

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