Skip to main content
Top
Published in: Respiratory Research 1/2018

Open Access 01-12-2018 | Editorial

The underestimated danger of E-cigarettes - also in the absence of nicotine

Author: Martina Korfei

Published in: Respiratory Research | Issue 1/2018

Login to get access

Excerpt

Electronic cigarettes (E-cigarettes, ECs) are electronic devices that heat a liquid – usually comprising propylene glycol and glycerol, with or without nicotine and flavors, stored in disposable or refillable cartridges or a reservoir – into an aerosol (vapor) for inhalation [1]. Since ECs appeared on the market in 2006 they have become increasingly popular, especially among young people [1, 2]. E-cigarettes are marketed as a safer and “healthier” alternative to traditional cigarettes, and it is suggested in the mass media that ECs help smokers to stop smoking long-term, or to help smokers unable to stop smoking entirely to reduce their tobacco cigarette consumption [3]. However, the number of never-smoking youth who use ECs with or without nicotine is dramatically increasing. ECs are new sources of the highly addictive substance nicotine, which has a proven harmful effect on health [4, 5]. And, the advertising of nicotine-free ECs with liquids of fruit and sweet flavors is particularly likely to encourage young people to start using the E-cigarette. The Forum of International Respiratory Societies also revealed that E-cigarette (EC)-smoking is a significant public health problem because EC-use simulate smoking behaviour and can be done in public places, which together with its alarmingly growing popularity may increase the social approval for smoking and nicotine addiction [6]. …
Literature
1.
go back to reference Caponnetto P, Campagna D, Papale G, Russo C, Polosa R. The emerging phenomenon of electronic cigarettes. Expert Rev Respir Med. 2012;6:63–74.CrossRefPubMed Caponnetto P, Campagna D, Papale G, Russo C, Polosa R. The emerging phenomenon of electronic cigarettes. Expert Rev Respir Med. 2012;6:63–74.CrossRefPubMed
2.
go back to reference Murthy VH. E-cigarette use among youth and young adults: a major public health concern. JAMA Pediatr. 2017;171:209–10.CrossRefPubMed Murthy VH. E-cigarette use among youth and young adults: a major public health concern. JAMA Pediatr. 2017;171:209–10.CrossRefPubMed
4.
go back to reference Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology. 2010;210:453–69.CrossRefPubMedPubMedCentral Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology. 2010;210:453–69.CrossRefPubMedPubMedCentral
6.
go back to reference Schraufnagel DE, Blasi F, Drummond MB, Lam DC, Latif E, Rosen MJ, Sansores R, Van Zyl-Smit R. Electronic cigarettes. A position statement of the forum of international respiratory societies. Am J Respir Crit Care Med. 2014;190:611–8.CrossRefPubMed Schraufnagel DE, Blasi F, Drummond MB, Lam DC, Latif E, Rosen MJ, Sansores R, Van Zyl-Smit R. Electronic cigarettes. A position statement of the forum of international respiratory societies. Am J Respir Crit Care Med. 2014;190:611–8.CrossRefPubMed
7.
go back to reference Uchiyama S, Ohta K, Inaba Y, Kunugita N. Determination of carbonyl compounds generated from the E-cigarette using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine, followed by high-performance liquid chromatography. Anal Sci. 2013;29:1219–22.CrossRefPubMed Uchiyama S, Ohta K, Inaba Y, Kunugita N. Determination of carbonyl compounds generated from the E-cigarette using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine, followed by high-performance liquid chromatography. Anal Sci. 2013;29:1219–22.CrossRefPubMed
8.
go back to reference Jensen RP, Luo W, Pankow JF, Strongin RM, Peyton DH. Hidden formaldehyde in e-cigarette aerosols. N Engl J Med. 2015;372:392–4.CrossRefPubMed Jensen RP, Luo W, Pankow JF, Strongin RM, Peyton DH. Hidden formaldehyde in e-cigarette aerosols. N Engl J Med. 2015;372:392–4.CrossRefPubMed
9.
go back to reference Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23:133–9.CrossRefPubMed Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23:133–9.CrossRefPubMed
10.
go back to reference McAuley TR, Hopke PK, Zhao J, Babaian S. Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol. 2012;24:850–7.CrossRefPubMed McAuley TR, Hopke PK, Zhao J, Babaian S. Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol. 2012;24:850–7.CrossRefPubMed
11.
go back to reference Varlet V, Farsalinos K, Augsburger M, Thomas A, Etter JF. Toxicity assessment of refill liquids for electronic cigarettes. Int J Environ Res Public Health. 2015;12:4796–815.CrossRefPubMedPubMedCentral Varlet V, Farsalinos K, Augsburger M, Thomas A, Etter JF. Toxicity assessment of refill liquids for electronic cigarettes. Int J Environ Res Public Health. 2015;12:4796–815.CrossRefPubMedPubMedCentral
12.
go back to reference Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013;8:e57987.CrossRefPubMedPubMedCentral Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013;8:e57987.CrossRefPubMedPubMedCentral
13.
go back to reference Farsalinos KE, Kistler KA, Pennington A, Spyrou A, Kouretas D, Gillman G. Aldehyde levels in e-cigarette aerosol: findings from a replication study and from use of a new-generation device. Food Chem Toxicol. 2018;111:64–70.CrossRefPubMed Farsalinos KE, Kistler KA, Pennington A, Spyrou A, Kouretas D, Gillman G. Aldehyde levels in e-cigarette aerosol: findings from a replication study and from use of a new-generation device. Food Chem Toxicol. 2018;111:64–70.CrossRefPubMed
14.
go back to reference Farsalinos KE, Voudris V. Do flavouring compounds contribute to aldehyde emissions in e-cigarettes? Food Chem Toxicol. 2018;115:212–7.CrossRefPubMed Farsalinos KE, Voudris V. Do flavouring compounds contribute to aldehyde emissions in e-cigarettes? Food Chem Toxicol. 2018;115:212–7.CrossRefPubMed
15.
go back to reference Farsalinos KE, Voudris V, Poulas K. E-cigarettes generate high levels of aldehydes only in 'dry puff' conditions. Addiction. 2015;110:1352–6.CrossRefPubMed Farsalinos KE, Voudris V, Poulas K. E-cigarettes generate high levels of aldehydes only in 'dry puff' conditions. Addiction. 2015;110:1352–6.CrossRefPubMed
16.
go back to reference Farsalinos KE, Voudris V, Spyrou A, Poulas K. E-cigarettes emit very high formaldehyde levels only in conditions that are aversive to users: a replication study under verified realistic use conditions. Food Chem Toxicol. 2017;109:90–4.CrossRefPubMed Farsalinos KE, Voudris V, Spyrou A, Poulas K. E-cigarettes emit very high formaldehyde levels only in conditions that are aversive to users: a replication study under verified realistic use conditions. Food Chem Toxicol. 2017;109:90–4.CrossRefPubMed
17.
go back to reference Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015;10:e0116732.CrossRefPubMedPubMedCentral Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015;10:e0116732.CrossRefPubMedPubMedCentral
18.
go back to reference Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, et al. Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One. 2015;10:e0116861.CrossRefPubMedPubMedCentral Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, et al. Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One. 2015;10:e0116861.CrossRefPubMedPubMedCentral
19.
go back to reference Lee HW, Park SH, Weng MW, Wang HT, Huang WC, Lepor H, Wu XR, Chen LC, Tang MS. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A. 2018;115:E1560–9.CrossRefPubMedPubMedCentral Lee HW, Park SH, Weng MW, Wang HT, Huang WC, Lepor H, Wu XR, Chen LC, Tang MS. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A. 2018;115:E1560–9.CrossRefPubMedPubMedCentral
20.
go back to reference Reidel B, Radicioni G, Clapp PW, Ford AA, Abdelwahab S, Rebuli ME, Haridass P, Alexis NE, Jaspers I, Kesimer M. E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion. Am J Respir Crit Care Med. 2018;197:492–501.CrossRefPubMed Reidel B, Radicioni G, Clapp PW, Ford AA, Abdelwahab S, Rebuli ME, Haridass P, Alexis NE, Jaspers I, Kesimer M. E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion. Am J Respir Crit Care Med. 2018;197:492–501.CrossRefPubMed
21.
go back to reference Staudt MR, Salit J, Kaner RJ, Hollmann C, Crystal RG. Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes. Respir Res. 2018;19:78.CrossRefPubMedPubMedCentral Staudt MR, Salit J, Kaner RJ, Hollmann C, Crystal RG. Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes. Respir Res. 2018;19:78.CrossRefPubMedPubMedCentral
22.
go back to reference Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene. 2015;34:73–83.CrossRefPubMed Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene. 2015;34:73–83.CrossRefPubMed
23.
go back to reference Visser S, Yang X. LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle. 2010;9:3892–903.CrossRefPubMed Visser S, Yang X. LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle. 2010;9:3892–903.CrossRefPubMed
24.
go back to reference Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massague J. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014;156:1002–16.CrossRefPubMedPubMedCentral Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massague J. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014;156:1002–16.CrossRefPubMedPubMedCentral
25.
go back to reference Moody TW, Ramos-Alvarez I, Moreno P, Mantey SA, Ridnour L, Wink D, Jensen RT. Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells. Peptides. 2017;90:90–9.CrossRefPubMedPubMedCentral Moody TW, Ramos-Alvarez I, Moreno P, Mantey SA, Ridnour L, Wink D, Jensen RT. Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells. Peptides. 2017;90:90–9.CrossRefPubMedPubMedCentral
26.
go back to reference Schleussner N, Merkel O, Costanza M, Liang HC, Hummel F, Romagnani C, Durek P, Anagnostopoulos I, Hummel M, Johrens K, et al. The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia. 2018; Schleussner N, Merkel O, Costanza M, Liang HC, Hummel F, Romagnani C, Durek P, Anagnostopoulos I, Hummel M, Johrens K, et al. The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia. 2018;
27.
go back to reference De Marco C, Laudanna C, Rinaldo N, Oliveira DM, Ravo M, Weisz A, Ceccarelli M, Caira E, Rizzuto A, Zoppoli P, et al. Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. PLoS One. 2017;12:e0178865.CrossRefPubMedPubMedCentral De Marco C, Laudanna C, Rinaldo N, Oliveira DM, Ravo M, Weisz A, Ceccarelli M, Caira E, Rizzuto A, Zoppoli P, et al. Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. PLoS One. 2017;12:e0178865.CrossRefPubMedPubMedCentral
28.
go back to reference Schmidt MO, Garman KA, Lee YG, Zuo C, Beck PJ, Tan M, Aguilar-Pimentel JA, Ollert M, Schmidt-Weber C, Fuchs H, et al. The role of fibroblast growth factor-binding protein 1 in skin carcinogenesis and inflammation. J Invest Dermatol. 2018;138:179–88.CrossRefPubMed Schmidt MO, Garman KA, Lee YG, Zuo C, Beck PJ, Tan M, Aguilar-Pimentel JA, Ollert M, Schmidt-Weber C, Fuchs H, et al. The role of fibroblast growth factor-binding protein 1 in skin carcinogenesis and inflammation. J Invest Dermatol. 2018;138:179–88.CrossRefPubMed
29.
go back to reference Liu B, Xu K, Jiang Y, Li X. Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol. 2014;7:7863–71.PubMedPubMedCentral Liu B, Xu K, Jiang Y, Li X. Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol. 2014;7:7863–71.PubMedPubMedCentral
30.
go back to reference Pace E, Ferraro M, Di Vincenzo S, Bruno A, Giarratano A, Scafidi V, Lipari L, Di Benedetto DV, Sciarrino S, Gjomarkaj M. Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence. Immunology. 2013;139:245–55.CrossRefPubMedPubMedCentral Pace E, Ferraro M, Di Vincenzo S, Bruno A, Giarratano A, Scafidi V, Lipari L, Di Benedetto DV, Sciarrino S, Gjomarkaj M. Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence. Immunology. 2013;139:245–55.CrossRefPubMedPubMedCentral
31.
go back to reference Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling. Res Vet Sci. 2016;104:40–9.CrossRefPubMed Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling. Res Vet Sci. 2016;104:40–9.CrossRefPubMed
32.
go back to reference Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, et al. Role of Spdef in the regulation of Muc5b expression in the Airways of Naive and Muco-obstructed Mice. Am J Respir Cell Mol Biol. 2018; Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, et al. Role of Spdef in the regulation of Muc5b expression in the Airways of Naive and Muco-obstructed Mice. Am J Respir Cell Mol Biol. 2018;
33.
go back to reference Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, et al. Airway mucin concentration as a marker of chronic bronchitis. N Engl J Med. 2017;377:911–22.CrossRefPubMedPubMedCentral Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, et al. Airway mucin concentration as a marker of chronic bronchitis. N Engl J Med. 2017;377:911–22.CrossRefPubMedPubMedCentral
34.
go back to reference Bhalla K, Chugh M, Mehrotra S, Rathore S, Tousif S, Prakash Dwivedi V, Prakash P, Kumar Samuchiwal S, Kumar S, Kumar Singh D, et al. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and plasmodium falciparum. Nat Commun. 2015;6:6049.CrossRefPubMed Bhalla K, Chugh M, Mehrotra S, Rathore S, Tousif S, Prakash Dwivedi V, Prakash P, Kumar Samuchiwal S, Kumar S, Kumar Singh D, et al. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and plasmodium falciparum. Nat Commun. 2015;6:6049.CrossRefPubMed
35.
go back to reference Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T, Yoshie O. CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon. J Immunol. 2018;200:800–9.CrossRefPubMed Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T, Yoshie O. CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon. J Immunol. 2018;200:800–9.CrossRefPubMed
36.
go back to reference Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Oncotarget. 2017;8:31270–87.CrossRefPubMedPubMedCentral Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Oncotarget. 2017;8:31270–87.CrossRefPubMedPubMedCentral
37.
go back to reference Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S, Minamiya Y. Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer. Tumour Biol. 2014;35:4257–65.CrossRefPubMed Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S, Minamiya Y. Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer. Tumour Biol. 2014;35:4257–65.CrossRefPubMed
38.
go back to reference Lebender LF, Prunte L, Rumzhum NN, Ammit AJ. Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: implications for lung health and disease. Pulm Pharmacol Ther. 2018;49:75–87.CrossRefPubMed Lebender LF, Prunte L, Rumzhum NN, Ammit AJ. Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: implications for lung health and disease. Pulm Pharmacol Ther. 2018;49:75–87.CrossRefPubMed
39.
go back to reference Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol. 2009;183:2642–9.CrossRefPubMedPubMedCentral Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol. 2009;183:2642–9.CrossRefPubMedPubMedCentral
40.
go back to reference Pinto AR, Godwin JW, Chandran A, Hersey L, Ilinykh A, Debuque R, Wang L, Rosenthal NA. Age-related changes in tissue macrophages precede cardiac functional impairment. Aging (Albany NY). 2014;6:399–413.CrossRef Pinto AR, Godwin JW, Chandran A, Hersey L, Ilinykh A, Debuque R, Wang L, Rosenthal NA. Age-related changes in tissue macrophages precede cardiac functional impairment. Aging (Albany NY). 2014;6:399–413.CrossRef
41.
go back to reference Xia H, Ren X, Bolte CS, Ustiyan V, Zhang Y, Shah TA, Kalin TV, Whitsett JA, Kalinichenko VV. Foxm1 regulates resolution of hyperoxic lung injury in newborns. Am J Respir Cell Mol Biol. 2015;52:611–21.CrossRefPubMedPubMedCentral Xia H, Ren X, Bolte CS, Ustiyan V, Zhang Y, Shah TA, Kalin TV, Whitsett JA, Kalinichenko VV. Foxm1 regulates resolution of hyperoxic lung injury in newborns. Am J Respir Cell Mol Biol. 2015;52:611–21.CrossRefPubMedPubMedCentral
Metadata
Title
The underestimated danger of E-cigarettes - also in the absence of nicotine
Author
Martina Korfei
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2018
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-018-0870-4

Other articles of this Issue 1/2018

Respiratory Research 1/2018 Go to the issue