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Respiratory Research
Published in: Respiratory Research 1/2018

Open Access 01-12-2018 | Letter to the Editor

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)

Authors: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates, Ann B. Millar

Published in: Respiratory Research | Issue 1/2018

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Abstract

Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Axxxa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Axxxa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Axxxa isoforms as drivers of fibrogenesis.
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Metadata
Title
Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
Authors
Shaney L. Barratt
Thomas Blythe
Khadija Ourradi
Caroline Jarrett
Gavin I. Welsh
David O. Bates
Ann B. Millar
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2018
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-017-0711-x

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