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Respiratory Research
Published in: Respiratory Research 1/2016

Open Access 01-12-2016 | Review

Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ

Authors: Paula N. Nonaka, Juan J. Uriarte, Noelia Campillo, Vinicius R. Oliveira, Daniel Navajas, Ramon Farré

Published in: Respiratory Research | Issue 1/2016

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Abstract

A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approach is how to drive stem cell differentiation onto the different lung cell phenotypes. Whereas the use of soluble factors as agents to modulate the fate of stem cells was established from an early stage of the research with this type of cells, it took longer to recognize that the physical microenvironment locally sensed by stem cells (e.g. substrate stiffness, 3D architecture, cyclic stretch, shear stress, air-liquid interface, oxygenation gradient) also contributes to their differentiation. The potential role played by physical stimuli would be particularly relevant in lung bioengineering since cells within the organ are physiologically subjected to two main stimuli required to facilitate efficient gas exchange: air ventilation and blood perfusion across the organ. The present review focuses on describing how the cell mechanical microenvironment can modulate stem cell differentiation and how these stimuli could be incorporated into lung bioreactors for optimizing organ bioengineering.
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Metadata
Title
Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ
Authors
Paula N. Nonaka
Juan J. Uriarte
Noelia Campillo
Vinicius R. Oliveira
Daniel Navajas
Ramon Farré
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-016-0477-6

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