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Open Access 01-12-2016 | Letter to the Editor

A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation

Authors: Charity G. Duran, Allison J. Burbank, Katherine H. Mills, Heather R. Duckworth, Maria M. Aleman, Matthew J. Kesic, David B. Peden, Yinghao Pan, Haibo Zhou, Michelle L. Hernandez

Published in: Respiratory Research | Issue 1/2016

Abstract

Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation.

Trial registration: NCT01625130. Registered 19 June, 2012.

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Title: A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
Authors: Charity G. Duran
Allison J. Burbank
Katherine H. Mills
Heather R. Duckworth
Maria M. Aleman
Matthew J. Kesic
David B. Peden
Yinghao Pan
Haibo Zhou
Michelle L. Hernandez
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-016-0406-8

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