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Respiratory Research
Published in: Respiratory Research 1/2016

Open Access 01-12-2016 | Review

Surfactant proteins, SP-A and SP-D, in respiratory fungal infections: their role in the inflammatory response

Authors: Laura Elena Carreto-Binaghi, El Moukhtar Aliouat, Maria Lucia Taylor

Published in: Respiratory Research | Issue 1/2016

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Abstract

Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs’ surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which are also known as pulmonary collectins, have an important function in the host’s lung immune response; they act as opsonins for different pathogens via a C-terminal carbohydrate recognition domain and enhance the attachment to phagocytic cells or show their own microbicidal activity by increasing the cellular membrane permeability. Interactions between the pulmonary collectins and bacteria or viruses have been extensively studied, but this is not the same for fungal pathogens. SP-A and SP-D bind glucan and mannose residues from fungal cell wall, but there is still a lack of information on their binding to other fungal carbohydrate residues. In addition, both their relation with immune cells for the clearance of these pathogens and the role of surfactant proteins’ regulation during respiratory fungal infections remain unknown. Here we highlight the relevant findings associated with SP-A and SP-D in those respiratory mycoses where the fungal infective propagules reach the lungs by the airways.
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Metadata
Title
Surfactant proteins, SP-A and SP-D, in respiratory fungal infections: their role in the inflammatory response
Authors
Laura Elena Carreto-Binaghi
El Moukhtar Aliouat
Maria Lucia Taylor
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-016-0385-9

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