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Open Access 01-12-2016 | Letter to the Editor

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Authors: Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown

Published in: Respiratory Research | Issue 1/2016

Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

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Title: β-Glucan exacerbates allergic airway responses to house dust mite allergen
Authors: Sabelo Hadebe
Frank Kirstein
Kaat Fierens
Pierre Redelinghuys
Graeme I. Murray
David L. Williams
Bart N. Lambrecht
Frank Brombacher
Gordon D. Brown
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-016-0352-5

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