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Asia Pacific Family Medicine
Published in: Asia Pacific Family Medicine 1/2017

Open Access 01-12-2017 | Research

Cancer-related post-treatment pain and its impact on health-related quality of life in breast cancer patients: a cross sectional study in Palestine

Authors: Nader H. Abu Farha, Mohammed T. Khatib, Husam Salameh, Sa’ed H. Zyoud

Published in: Asia Pacific Family Medicine | Issue 1/2017

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Abstract

Background

Post-treatment pain has been suggested as an important indicator for health-related quality of life (HRQOL) in patients with breast cancer. Therefore, this study was performed to examine the association between pain and its impact on HRQOL among breast cancer patients in Palestine. Also, this study aimed to determine the QOL profile for breast cancer patients and stated the factors associated with QOL.

Methods

A correlational cross-sectional study was conducted from May 2016 to November 2016 at Al-Watani Hospital and An-Najah National University Hospital in the Nablus district in Palestine. The five-level EuroQol five-dimensional instrument (EQ-5D-5L) was used to examine HRQOL. Pain severity and interference were assessed using the Brief Pain Inventory (BPI). Multiple linear regression analysis was performed to determine the most important variables related with HRQOL.

Results

One hundred and seventy patients were involved in this study. Overall, all participants were female, with a mean ± SD for age of 51.71 ± 11.11 years. The reported HRQOL of this study was measured by using the median EQ-5D-5L index score, which was 0.67 (interquartile range: 0.51–0.84). There were moderate negative correlations between EQ-5D-5L index score and pain severity score (r = − 0.58, p value < 0.001), and pain interference score (r = − 0.604, p-value < 0.001). Furthermore, univariate analysis showed that age, marital status, employment status, income, current condition of cancer, and post-treatment pain were associated with quality of life (p-value < 0.05). Regression analysis revealed that patients with high income (p-value = 0.003), patients with lower pain severity score (p-value < 0.001), and lower pain interference score (p-value = 0.018) were independently associated with high QOL.

Conclusions

This is the first study to present important data regarding QOL by using the EQ-5D-5L instruments that may help healthcare providers to identify patients at risk of low QOL. Healthcare providers and health strategy makers should be alerted to low level HRQOL among breast cancer patients with low income level, patients with post-treatment pain, especially in the state of severe pain, and the state of pain interfering with daily life to improve their HRQOL.
Literature
1.
Kleihues P, Stewart BW, Organization WH, Cancer IAfRo. World cancer report: International Agency for Research on Cancer. 2003.
2.
Peretti-Watel P, Bendiane MK, Spica L, Rey D. Pain narratives in breast cancer survivors. Pain Res Treat. 2012;2012:153060.PubMedPubMedCentral
3.
Diaconu C, Pantis C, Cirimbei C, Bordea C, Gruia MI, Blidaru A. Pain-associated biomarkers in breast cancer. J Med Life. 2015;8(1):32–6.PubMedPubMedCentral
4.
Groenvold M. Health-related quality of life in early breast cancer. Dan Med Bull. 2010;57(9):B4184.PubMed
5.
Andersen KG, Kehlet H. Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain. 2011;12(7):725–46.CrossRefPubMed
6.
Gulluoglu BM, Cingi A, Cakir T, Gercek A, Barlas A, Eti Z. Factors related to post-treatment chronic pain in breast cancer survivors: the interference of pain with life functions. Int J Fertil Womens Med. 2006;51(2):75–82.PubMed
7.
Gunnars B, Nygren P, Glimelius B. Assessment of quality of life during chemotherapy. Acta Oncol. 2001;40(2–3):175–84.CrossRefPubMed
8.
Goodwin PJ, Black JT, Bordeleau LJ, Ganz PA. Health-related quality-of-life measurement in randomized clinical trials in breast cancer–taking stock. J Natl Cancer Inst. 2003;95(4):263–81.CrossRefPubMed
9.
10.
Haddou Rahou B, El Rhazi K, Ouasmani F, Nejjari C, Bekkali R, Montazeri A, Mesfioui A. Quality of life in Arab women with breast cancer: a review of the literature. Health Qual Life Outcomes. 2016;14(64):016–0468.
11.
12.
Burckhardt CS, Jones KD. Effects of chronic widespread pain on the health status and quality of life of women after breast cancer surgery. Health Qual Life Outcomes. 2005;3:30.CrossRefPubMedPubMedCentral
13.
Shockney LD. Pain following breast cancer surgery: a quality-of-life issue. Arch Surg. 2010;145(3):224–5.CrossRefPubMed
14.
Khalili N, Farajzadegan Z, Mokarian F, Bahrami F. Coping strategies, quality of life and pain in women with breast cancer. Iran J Nurs Midwifery Res. 2013;18(2):105–11.PubMedPubMedCentral
15.
Glare PA, Davies PS, Finlay E, Gulati A, Lemanne D, Moryl N, Oeffinger KC, Paice JA, Stubblefield MD, Syrjala KL. Pain in cancer survivors. J Clin Oncol. 2014;32(16):1739–47.CrossRefPubMedPubMedCentral
16.
Schou Bredal I, Smeby NA, Ottesen S, Warncke T, Schlichting E. Chronic pain in breast cancer survivors: comparison of psychosocial, surgical, and medical characteristics between survivors with and without pain. J Pain Symptom Manage. 2014;48(5):852–62.CrossRefPubMed
17.
18.
Shawawra M, Khleif AD. Palliative care situation in Palestinian authority. J Pediatr Hematol Oncol. 2011;33(Suppl 1):S64–7.CrossRefPubMed
19.
Husein AI, Ali-Shtayeh MS, Jondi WJ, Zatar NA, Abu-Reidah IM, Jamous RM. In vitro antioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine. Pharm Biol. 2014;52(10):1249–55.CrossRefPubMed
20.
Salah Z, Itzhaki E, Aqeilan RI. The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the hippo tumor suppressor pathway. Oncotarget. 2014;5(21):10886–900.CrossRefPubMedPubMedCentral
21.
Cleeland CS, Ryan KM. Pain assessment: global use of the brief pain inventory. Ann Acad Med Singapore. 1994;23(2):129–38.PubMed
22.
Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med. 2001;33(5):337–43.CrossRefPubMed
23.
24.
Horowitz E, Abadi-Korek I, Shani M, Shemer J. EQ-5D as a generic measure of health-related quality of life in Israel: reliability, validity and responsiveness. Isr Med Assoc J. 2010;12(12):715–20.PubMed
25.
Zyoud SH, Al-Jabi SW, Sweileh WM, Wildali AH, Saleem HM, Aysa HA, Badwan MA, Awang R, Morisky DE. Health-related quality of life associated with treatment adherence in patients with hypertension: a cross-sectional study. Int J Cardiol. 2013;168(3):2981–3.CrossRefPubMed
26.
Zyoud SH, Daraghmeh DN, Mezyed DO, Khdeir RL, Sawafta MN, Ayaseh NA, Tabeeb GH, Sweileh WM, Awang R, Al-Jabi SW. Factors affecting quality of life in patients on haemodialysis: a cross-sectional study from Palestine. BMC Nephrol. 2016;17(1):44.CrossRefPubMedPubMedCentral
27.
Zyoud SH, Al-Jabi SW, Sweileh WM, Arandi DA, Dabeek SA, Esawi HH, Atyeh RH, Abu-Ali HA, Sleet YI, Abd-Alfatah BM, et al. Relationship of treatment satisfaction to health-related quality of life among Palestinian patients with type 2 diabetes mellitus: findings from a cross-sectional study. J Clin Transl Endocrinol. 2015;2(2):66–71.CrossRef
28.
Agborsangaya CB, Lahtinen M, Cooke T, Johnson JA. Comparing the EQ-5D 3L and 5L: measurement properties and association with chronic conditions and multimorbidity in the general population. Health Qual Life Outcomes. 2014;12:74.CrossRefPubMedPubMedCentral
29.
Al-Jabi SW, Zyoud SH, Sweileh WM, Wildali AH, Saleem HM, Aysa HA, Badwan MA, Awang R. Relationship of treatment satisfaction to health-related quality of life: findings from a cross-sectional survey among hypertensive patients in Palestine. Health Expect. 2015;18(6):3336–48.CrossRefPubMed
30.
Saffari M, Pakpour AH, Naderi MK, Koenig HG, Baldacchino DR, Piper CN. Spiritual coping, religiosity and quality of life: a study on Muslim patients undergoing haemodialysis. Nephrology (Carlton). 2013;18(4):269–75.CrossRef
31.
Al-Jabi SW, Zyoud SH, Sweileh WM, Wildali AH, Saleem HM, Aysa HA, Badwan MA, Awang R. Assessment of health-related quality of life among hypertensive patients: a cross-sectional study from Palestine. J Public Health. 2014;22(3):277–86.CrossRef
32.
33.
Wallwiener M, Simoes E, Sokolov AN, Brucker SY, Fasching PA, Graf J. Health-related quality of life in metastatic and adjuvant breast cancer patients. Geburtshilfe Frauenheilkd. 2016;76(10):1065–73.CrossRefPubMedPubMedCentral
34.
Kimman ML, Dirksen CD, Lambin P, Boersma LJ. Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment. Health Qual Life Outcomes. 2009;7(11):1477–7525.
35.
Lidgren M, Wilking N, Jonsson B, Rehnberg C. Health related quality of life in different states of breast cancer. Qual Life Res. 2007;16(6):1073–81.CrossRefPubMed
36.
Kimman ML, Dirksen CD, Lambin P, Boersma LJ. Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment. Health Qual Life Outcomes. 2009;7:11.CrossRefPubMedPubMedCentral
37.
Shahbazi R, Akbari ME, Hashemian M, Abbasi M, Jalali S, Homayounfar R, Davoodi SH. High body mass index and young age are not associated with post-mastectomy pain syndrome in breast cancer survivors: a case-control study. Iran J Cancer Prev. 2015;8(1):29–35.PubMedPubMedCentral
38.
Ganesh S, Lye MS, Lau FN. Quality of life among breast cancer patients In Malaysia. Asian Pac J Cancer Prev. 2016;17(4):1677–84.CrossRefPubMed
39.
Loerzel VW, McNees P, Powel LL, Su X, Meneses K. Quality of life in older women with early-stage breast cancer in the first year of survivorship. Oncol Nurs Forum. 2008;35(6):924–32.CrossRefPubMed
40.
Merom D, Sinnreich R, Aboudi V, Kark JD, Nassar H. Lifestyle physical activity among urban Palestinians and Israelis: a cross-sectional comparison in the Palestinian-Israeli Jerusalem risk factor study. BMC Public Health. 2012;12:90.CrossRefPubMedPubMedCentral
41.
Reyes-Gibby CC, Anderson KO, Morrow PK, Shete S, Hassan S. Depressive symptoms and health-related quality of life in breast cancer survivors. J Womens Health. 2012;21(3):311–8.CrossRef
42.
Ivanauskiene R, Kregzdyte R, Padaiga Z. Evaluation of health-related quality of life in patients with breast cancer. Medicina. 2010;46(5):351–9.PubMed
43.
Leung J, Pachana NA, McLaughlin D. Social support and health-related quality of life in women with breast cancer: a longitudinal study. Psychooncology. 2014;23(9):1014–20.CrossRefPubMed
44.
Tobiasz-Adamczyk B. Health-related quality of life in women after cancer treatment. Przegl Lek. 2012;69(2):67–71.PubMed
45.
Yan B, Yang LM, Hao LP, Yang C, Quan L, Wang LH, Wu Z, Li XP, Gao YT, Sun Q, et al. Determinants of quality of life for breast cancer patients in Shanghai, China. PLoS ONE. 2016;11(4):e0153714.CrossRefPubMedPubMedCentral
46.
Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302(18):1985–92.CrossRefPubMed
47.
Wallace MS, Wallace AM, Lee J, Dobke MK. Pain after breast surgery: a survey of 282 women. Pain. 1996;66(2–3):195–205.CrossRefPubMed
48.
Tasmuth T, Blomqvist C, Kalso E. Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units. Eur J Surg Oncol. 1999;25(1):38–43.CrossRefPubMed
49.
Tasmuth T, von Smitten K, Kalso E. Pain and other symptoms during the first year after radical and conservative surgery for breast cancer. Br J Cancer. 1996;74(12):2024–31.CrossRefPubMedPubMedCentral
50.
Caffo O, Amichetti M, Ferro A, Lucenti A, Valduga F, Galligioni E. Pain and quality of life after surgery for breast cancer. Breast Cancer Res Treat. 2003;80(1):39–48.CrossRefPubMed
51.
Green CR, Hart-Johnson T, Loeffler DR. Cancer-related chronic pain: examining quality of life in diverse cancer survivors. Cancer. 2011;117(9):1994–2003.CrossRefPubMed
52.
Miaskowski C, Dibble SL. The problem of pain in outpatients with breast cancer. Oncol Nurs Forum. 1995;22(5):791–7.PubMed
53.
Katz J, Poleshuck EL, Andrus CH, Hogan LA, Jung BF, Kulick DI, Dworkin RH. Risk factors for acute pain and its persistence following breast cancer surgery. Pain. 2005;119(1–3):16–25.CrossRefPubMed
54.
Poleshuck EL, Katz J, Andrus CH, Hogan LA, Jung BF, Kulick DI, Dworkin RH. Risk factors for chronic pain following breast cancer surgery: a prospective study. J Pain. 2006;7(9):626–34.CrossRefPubMed
55.
Forsythe LP, Alfano CM, George SM, McTiernan A, Baumgartner KB, Bernstein L, Ballard-Barbash R. Pain in long-term breast cancer survivors: the role of body mass index, physical activity, and sedentary behavior. Breast Cancer Res Treat. 2013;137(2):617–30.CrossRefPubMed
56.
Kroenke K, Theobald D, Wu J, Loza JK, Carpenter JS, Tu W. The association of depression and pain with health-related quality of life, disability, and health care use in cancer patients. J Pain Symptom Manage. 2010;40(3):327–41.CrossRefPubMedPubMedCentral
57.
Lee ES, Lee MK, Kim SH, Ro JS, Kang HS, Kim SW, Lee KS, Yun YH. Health-related quality of life in survivors with breast cancer 1 year after diagnosis compared with the general population: a prospective cohort study. Ann Surg. 2011;253(1):101–8.CrossRefPubMed
58.
Puetzler J, Feldmann RE Jr, Brascher AK, Gerhardt A, Benrath J. Improvements in health-related quality of life by comprehensive cancer pain therapy: a pilot study with breast cancer outpatients under palliative chemotherapy. Oncol Res Treat. 2014;37(9):456–62.CrossRefPubMed
Metadata
Title
Cancer-related post-treatment pain and its impact on health-related quality of life in breast cancer patients: a cross sectional study in Palestine
Authors
Nader H. Abu Farha
Mohammed T. Khatib
Husam Salameh
Sa’ed H. Zyoud
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Asia Pacific Family Medicine / Issue 1/2017
Electronic ISSN: 1447-056X
DOI
https://doi.org/10.1186/s12930-017-0037-3

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