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BMC Medicine
Published in: BMC Medicine 1/2021

Open Access 01-12-2021 | Research article

A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

Authors: Wei Liu, Åsa Johansson, Helge Rask-Andersen, Mathias Rask-Andersen

Published in: BMC Medicine | Issue 1/2021

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Abstract

Background

Sensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss is not fully elucidated.

Methods

We performed genome-wide association studies (GWAS) for hearing loss-related traits in the UK Biobank (N = 362,396) and selected a high confidence set of ten hearing-associated gene products for staining in human cochlear samples: EYA4, LMX1A, PTK2/FAK, UBE3B, MMP2, SYNJ2, GRM5, TRIOBP, LMO-7, and NOX4.

Results

All proteins were found to be expressed in human cochlear structures. Our findings illustrate cochlear structures that mediate mechano-electric transduction of auditory stimuli, neuronal conductance, and neuronal plasticity to be involved in age-related hearing loss.

Conclusions

Our results suggest common genetic variation to influence structural resilience to damage as well as cochlear recovery after trauma, which protect against accumulated damage to cochlear structures and the development of hearing loss over time.
Appendix
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Metadata
Title
A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
Authors
Wei Liu
Åsa Johansson
Helge Rask-Andersen
Mathias Rask-Andersen
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2021
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-021-02169-0

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