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BMC Medicine
Published in: BMC Medicine 1/2021

01-12-2021 | Zika Virus | Commentary

Vertical transmission of Zika virus and the repercussions on children: the knowledge is not complete

Authors: M. I. Moreira, S. H. Villela, M. D. B. B. Meio

Published in: BMC Medicine | Issue 1/2021

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Excerpt

The association between Zika virus (ZIKV) infection in pregnancy with neurological abnormalities such as microcephaly, brain calcifications, epilepsy, eye and hearing impairments, and developmental delays has been described in recent years [1‐3]. Despite several published studies reporting development delays in children after prenatal exposure to ZIKV, several doubts remain and hinder ongoing studies, mainly related to the absence of serological tests capable of identifying asymptomatic cases, making it difficult to implement unexposed groups in the cohorts [1‐4]. This is further complicated by the difficulty of diagnosing ZIKV infection retrospectively, because of the narrow period of viremia and short-lived immunoglobulin M (IgM) responses, plus serologic cross-reactivity with dengue virus, highly prevalent in many countries [4, 5]. …
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de Araújo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, de Melo APL, Valongueiro S, de Albuquerque MFPM, Braga C, Filho SPB, Cordeiro MT, Vazquez E, Cruz DDCS, Henriques CMP, Bezerra LCA, Castanha PMDS, Dhalia R, Marques-Júnior ETA, Martelli CMT, Rodrigues LC; investigators from the Microcephaly Epidemic Research Group; Brazilian Ministry of Health; Pan American Health Organization; Instituto de Medicina Integral Professor Fernando Figueira; State Health Department of Pernambuco. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis. 2018;18(3):328–336.
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Okido MM, Bettiol H, Barbieri MA, Marcolin AC, Quintana SM, Cardoso VC, Del-Ben CM, Cavalli RC. Can increased resistance to uterine artery flow be a risk factor for adverse neurodevelopmental outcomes in childhood? A prospective cohort study. J Obstet Gynaecol. 2020;40(6):784–91.CrossRef
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Lebov JF, Arias JF, Balmaseda A, Britt W, Cordero JF, Galvão LA, Garces AL, Hambidge KM, Harris E, Ko A, Krebs N, Marques ETA, Martinez AM, McClure E, Miranda-Filho DB, Moreira MEL, Mussi-Pinhata MM, Ochoa TJ, Osorio JE, Scalabrin DMF, Schultz-Cherry S, Seage GR 3rd, Stolka K, Ugarte-Gil CA, Vega CMV, Welton M, Ximenes R, Zorrilla C. International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol. BMC Pregnancy Childbirth. 2019;19(1):282.CrossRef
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Metadata
Title
Vertical transmission of Zika virus and the repercussions on children: the knowledge is not complete
Authors
M. I. Moreira
S. H. Villela
M. D. B. B. Meio
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2021
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-021-01901-0

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