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BMC Medicine
Published in: BMC Medicine 1/2019

Open Access 01-12-2019 | Artificial Intelligence | Commentary

New approaches for detecting cancer with circulating cell-free DNA

Authors: Clare Fiala, Eleftherios P. Diamandis

Published in: BMC Medicine | Issue 1/2019

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Excerpt

Circulating cell-free DNA (cfDNA), released from normal and cancerous cells, is an exciting new biomarker. Circulating tumor DNA (ctDNA) usually contains genetic changes that could be useful for detecting cancer. Various laboratories have reported impressive clinical data, with cancer detection sensitivities ranging from 50 to 70%, calculated at 90–95% specificities [1‐3]. …
Literature
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Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, et al. Direct detection of early-stage cancer using circulating tumor DNA. Sci Transl Med. 2017;9:eaan2415.CrossRef
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Cohen JD, Li L, Wang Y, Thoburn C, Afsari B, Danilova L, et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science. 2018;359:926–30.CrossRef
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Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature. 2019;570:385–9.CrossRef
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Fiala C, Kulasingam V, Diamandis EP. Circulating tumor DNA for early cancer detection. J Appl Lab Med. 2018;(2) 036393.
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Diamandis EP, Fiala C. Can circulating tumor DNA be used for direct and early stage cancer detection? F1000Res. 2017;6:2129.CrossRef
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Fiala C, Diamandis EP. Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection. BMC Med. 2018;16:166.CrossRef
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Liu MC, Maddala T, Aravanis A, et al. Breast cancer cell-free DNA (cfDNA) profiles reflect underlying tumor biology: the circulating cell-free genome atlas (CCGA) study. J Clin Oncol. 2018;36(15_suppl):536.CrossRef
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Cramer DW, Bast RC Jr, Berg CD, Diamandis EP, Godwin AK, Hartge P, et al. Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens. Cancer Prev Res (Phila). 2011;4:365–74.CrossRef
Metadata
Title
New approaches for detecting cancer with circulating cell-free DNA
Authors
Clare Fiala
Eleftherios P. Diamandis
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2019
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-019-1400-z

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