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BMC Medicine
Published in: BMC Medicine 1/2019

Open Access 01-12-2019 | Graft-Versus-Host Disease | Correspondence

Advanced cell therapeutics are changing the clinical landscape: will mesenchymal stromal cells be a part of it?

Author: Richard Schäfer

Published in: BMC Medicine | Issue 1/2019

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Abstract

During the past 15 years there have been dramatic changes in the medical landscape, particularly in oncology and regenerative medicine. Cell therapies have played a substantial part in this progress. Cellular immunotherapies can use immune cells, such as T cells or natural killer cells that, after functional modification ex vivo, exert powerful anti-cancer effects when given to the patient. Innovative technologies, such as re-programming terminally differentiated cells into pluripotent stem cells or into other cell types and applying specific enzymes to more precisely edit the human genome, are paving the way towards more potent cell and gene therapies.
Mesenchymal stromal cells are promising cellular immunotherapeutics, which also have potential for use in tissue engineering strategies and other regenerative medicine applications. However, substantial gaps in our knowledge of their biology and therapeutic efficacy present major challenges to their sustainable implementation in the clinical routine.
In this article, progress in the field of cell therapeutics during the past 15 years will be briefly discussed, with a focus on mesenchymal stromal cells, highlighting the impact of this field on patient care.
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Metadata
Title
Advanced cell therapeutics are changing the clinical landscape: will mesenchymal stromal cells be a part of it?
Author
Richard Schäfer
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2019
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-019-1289-6

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