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Published in: BMC Health Services Research 1/2019

Open Access 01-12-2019 | Care | Research article

Qualitative and quantitative research of medication review and drug-related problems in Hungarian community pharmacies: a pilot study

Authors: András Szilvay, Orsolya Somogyi, Attiláné Meskó, Romána Zelkó, Balázs Hankó

Published in: BMC Health Services Research | Issue 1/2019

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Abstract

Background

Pharmaceutical care is the pharmacist’s contribution to the care of individuals to optimize medicines use and improve health outcomes. The primary tool of pharmaceutical care is medication review. Defining and classifying Drug-Related Problems (DRPs) is an essential pillar of the medication review. Our objectives were to perform a pilot of medication review in Hungarian community pharmacies, a DRP classification was applied for the first time. Also, our goal was the qualitative and quantitative description of the discovered DRPs, and of the interventions for their solution in order to prove the safety relevance of the service and to map out the competence limits of GPs and community pharmacists to drug therapy.

Methods

The project took place in Hungarian community pharmacies. The study was performed with patients taking vitamin K antagonist (VKA) and/or ACE inhibitor and NSAID simultaneously (ACEI-NSAID). 61 pharmacists and 606 patients participated in the project. Pharmacists reviewed the medication for 3 months and the classification of DRPs was performed (category of DRP1 – DRP6). Patient data were statistically analyzed.

Results

Patients consumed on average 7.9 ± 3.1 medications and other products. 571 DRPs were detected in 540 patients, averaging 1.06 DRPs per patient (SD = 1.07). The highest frequency category was DRP5 (non-quantitative safety problem; 51.0%). The most common root cause was an interaction (42.0%) and non-adherence (19.4%.). The most commonly used intervention was education (25.4%) and medication replacement by the pharmacist (20.1%). The changing of the frequency and dosage in any direction were negligible.

Conclusions

Patients are struggling with many DRPs that can be assessed and categorized by this system and which remain unrecognizable without pharmacists. Further projects need to be developed to assist in the development of physician-pharmacist cooperation and the widespread dissemination of pharmaceutical care.
Literature
1.
go back to reference Allemann SS, van Mil JW, Botermann L, Berger K, Griese N, Hersberger KE. Pharmaceutical care: the PCNE definition 2013. Int J Clin Pharm. 2014;36(3):544–55.CrossRefPubMed Allemann SS, van Mil JW, Botermann L, Berger K, Griese N, Hersberger KE. Pharmaceutical care: the PCNE definition 2013. Int J Clin Pharm. 2014;36(3):544–55.CrossRefPubMed
2.
go back to reference Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice: the patient-centered approach to medication management. 3rd ed. McGraw Hill Professional; 2012. Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice: the patient-centered approach to medication management. 3rd ed. McGraw Hill Professional; 2012.
4.
go back to reference Geurts MM, Talsma J, Brouwers JR, de Gier JJ. Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient: a systematic review. Br J Clin Pharmacol. 2012;74(1):16–33.CrossRefPubMedPubMedCentral Geurts MM, Talsma J, Brouwers JR, de Gier JJ. Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient: a systematic review. Br J Clin Pharmacol. 2012;74(1):16–33.CrossRefPubMedPubMedCentral
5.
go back to reference Kwint HF, Bermingham L, Faber A, Gussekloo J, Bouvy ML. The relationship between the extent of collaboration of general practitioners and pharmacists and the implementation of recommendations arising from medication review: a systematic review. Drugs Aging. 2013;30(2):91–102.CrossRefPubMed Kwint HF, Bermingham L, Faber A, Gussekloo J, Bouvy ML. The relationship between the extent of collaboration of general practitioners and pharmacists and the implementation of recommendations arising from medication review: a systematic review. Drugs Aging. 2013;30(2):91–102.CrossRefPubMed
6.
go back to reference Christensen M, Lundh A. Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database Syst Rev. 2016;(2). Christensen M, Lundh A. Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database Syst Rev. 2016;(2).
7.
go back to reference Roth MT, Ivey JL, Esserman DA, Crisp G, Kurz J, Weinberger M. Individualized medication assessment and planning: optimizing medication use in older adults in the primary care setting. Pharmacotherapy. 2013;33(8):787–97.CrossRefPubMed Roth MT, Ivey JL, Esserman DA, Crisp G, Kurz J, Weinberger M. Individualized medication assessment and planning: optimizing medication use in older adults in the primary care setting. Pharmacotherapy. 2013;33(8):787–97.CrossRefPubMed
8.
go back to reference Leendertse AJ, de Koning GH, Goudswaard AN, Belitser SV, Verhoef M, de Gier HJ, et al. Preventing hospital admissions by reviewing medication (PHARM) in primary care: an open controlled study in an elderly population. J Clin Pharm Ther. 2013;38(5):379–87.CrossRefPubMed Leendertse AJ, de Koning GH, Goudswaard AN, Belitser SV, Verhoef M, de Gier HJ, et al. Preventing hospital admissions by reviewing medication (PHARM) in primary care: an open controlled study in an elderly population. J Clin Pharm Ther. 2013;38(5):379–87.CrossRefPubMed
9.
go back to reference Lenaghan E, Holland R, Brooks A. Home-based medication review in a high risk elderly population in primary care--the POLYMED randomised controlled trial. Age Ageing. 2007;36(3):292–7.CrossRefPubMed Lenaghan E, Holland R, Brooks A. Home-based medication review in a high risk elderly population in primary care--the POLYMED randomised controlled trial. Age Ageing. 2007;36(3):292–7.CrossRefPubMed
11.
go back to reference Hurmuz MZM, Janus SIM, van Manen JG. Changes in medicine prescription following a medication review in older high-risk patients with polypharmacy. Int J Clin Pharm. 2018;40(2):480–7.CrossRefPubMedPubMedCentral Hurmuz MZM, Janus SIM, van Manen JG. Changes in medicine prescription following a medication review in older high-risk patients with polypharmacy. Int J Clin Pharm. 2018;40(2):480–7.CrossRefPubMedPubMedCentral
12.
go back to reference Mudge A, Radnedge K, Kasper K, Mullins R, Adsett J, Rofail S, et al. Effects of a pilot multidisciplinary clinic for frequent attending elderly patients on deprescribing. Aust Health Rev. 2016;40(1):86–91.CrossRefPubMed Mudge A, Radnedge K, Kasper K, Mullins R, Adsett J, Rofail S, et al. Effects of a pilot multidisciplinary clinic for frequent attending elderly patients on deprescribing. Aust Health Rev. 2016;40(1):86–91.CrossRefPubMed
13.
go back to reference Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5(12).CrossRefPubMedPubMedCentral Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5(12).CrossRefPubMedPubMedCentral
14.
go back to reference Vinks TH, Egberts TC, de Lange TM, de Koning FH. Pharmacist-based medication review reduces potential drug-related problems in the elderly: the SMOG controlled trial. Drugs Aging. 2009;26(2):123–33.CrossRefPubMed Vinks TH, Egberts TC, de Lange TM, de Koning FH. Pharmacist-based medication review reduces potential drug-related problems in the elderly: the SMOG controlled trial. Drugs Aging. 2009;26(2):123–33.CrossRefPubMed
15.
go back to reference Messerli M, Blozik E, Vriends N, Hersberger KE. Impact of a community pharmacist-led medication review on medicines use in patients on polypharmacy - a prospective randomised controlled trial. BMC Health Serv Res. 2016;16(1):145.CrossRefPubMedPubMedCentral Messerli M, Blozik E, Vriends N, Hersberger KE. Impact of a community pharmacist-led medication review on medicines use in patients on polypharmacy - a prospective randomised controlled trial. BMC Health Serv Res. 2016;16(1):145.CrossRefPubMedPubMedCentral
16.
go back to reference Lenander C, Bondesson Å, Viberg N, Beckman A, Midlöv P. Effects of medication reviews on use of potentially inappropriate medications in elderly patients; a cross-sectional study in Swedish primary care. BMC Health Serv Res. 2018;18(1):616.CrossRefPubMedPubMedCentral Lenander C, Bondesson Å, Viberg N, Beckman A, Midlöv P. Effects of medication reviews on use of potentially inappropriate medications in elderly patients; a cross-sectional study in Swedish primary care. BMC Health Serv Res. 2018;18(1):616.CrossRefPubMedPubMedCentral
17.
go back to reference Chua SS, Kok LC, Yusof FAM, Tang GH, Lee SWH, Efendie B, et al. Pharmaceutical care issues identified by pharmacists in patients with diabetes, hypertension or hyperlipidaemia in primary care settings. BMC Health Serv Res. 2012;12(1):388.CrossRefPubMedPubMedCentral Chua SS, Kok LC, Yusof FAM, Tang GH, Lee SWH, Efendie B, et al. Pharmaceutical care issues identified by pharmacists in patients with diabetes, hypertension or hyperlipidaemia in primary care settings. BMC Health Serv Res. 2012;12(1):388.CrossRefPubMedPubMedCentral
18.
go back to reference Ensing HT, Koster ES, Dubero DJ, van Dooren AA, Bouvy ML. Collaboration between hospital and community pharmacists to address drug-related problems: the HomeCoMe-program: Res Social Adm Pharm; 2018. Ensing HT, Koster ES, Dubero DJ, van Dooren AA, Bouvy ML. Collaboration between hospital and community pharmacists to address drug-related problems: the HomeCoMe-program: Res Social Adm Pharm; 2018.
19.
go back to reference Geurts MM, Stewart RE, Brouwers JR, de Graeff PA, de Gier JJ. Patient beliefs about medicines and quality of life after a clinical medication review and follow-up by a pharmaceutical care plan: a study in elderly polypharmacy patients with a cardiovascular disorder. J Pharm Health Serv Res. 2015;6(4):171–6.CrossRef Geurts MM, Stewart RE, Brouwers JR, de Graeff PA, de Gier JJ. Patient beliefs about medicines and quality of life after a clinical medication review and follow-up by a pharmaceutical care plan: a study in elderly polypharmacy patients with a cardiovascular disorder. J Pharm Health Serv Res. 2015;6(4):171–6.CrossRef
20.
go back to reference Jodar-Sanchez F, Malet-Larrea A, Martin JJ, Garcia-Mochon L, Lopez Del Amo MP, Martinez-Martinez F, et al. Cost-utility analysis of a medication review with follow-up service for older adults with polypharmacy in community pharmacies in Spain: the conSIGUE program. Pharmacoeconomics. 2015;33(6):599–610.CrossRefPubMed Jodar-Sanchez F, Malet-Larrea A, Martin JJ, Garcia-Mochon L, Lopez Del Amo MP, Martinez-Martinez F, et al. Cost-utility analysis of a medication review with follow-up service for older adults with polypharmacy in community pharmacies in Spain: the conSIGUE program. Pharmacoeconomics. 2015;33(6):599–610.CrossRefPubMed
21.
go back to reference Cd C. Tercer Consenso de Granada sobre problemas relacionados con medicamentos (PRM) y resultados negativos asociados a la medicación (RNM). Ars Pharmaceutica. 2007;48(1):5–7. Cd C. Tercer Consenso de Granada sobre problemas relacionados con medicamentos (PRM) y resultados negativos asociados a la medicación (RNM). Ars Pharmaceutica. 2007;48(1):5–7.
22.
go back to reference Basger BJ, Moles RJ, Chen TF. Application of drug-related problem (DRP) classification systems: a review of the literature. Eur J Clin Pharmacol. 2014;70(7):799–815.CrossRefPubMed Basger BJ, Moles RJ, Chen TF. Application of drug-related problem (DRP) classification systems: a review of the literature. Eur J Clin Pharmacol. 2014;70(7):799–815.CrossRefPubMed
23.
go back to reference Kwint HF, Faber A, Gussekloo J, Bouvy ML. The contribution of patient interviews to the identification of drug-related problems in home medication review. J Clin Pharm Ther. 2012;37(6):674–80.CrossRefPubMed Kwint HF, Faber A, Gussekloo J, Bouvy ML. The contribution of patient interviews to the identification of drug-related problems in home medication review. J Clin Pharm Ther. 2012;37(6):674–80.CrossRefPubMed
24.
go back to reference Gooch K, Culleton BF, Manns BJ, Zhang J, Alfonso H, Tonelli M, et al. NSAID use and progression of chronic kidney disease. Am J Med. 2007;120(3):1–7.CrossRef Gooch K, Culleton BF, Manns BJ, Zhang J, Alfonso H, Tonelli M, et al. NSAID use and progression of chronic kidney disease. Am J Med. 2007;120(3):1–7.CrossRef
25.
go back to reference Page RL 2nd, O'Bryant CL, Cheng D, Dow TJ, Ky B, Stein CM, et al. Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association. Circulation. 2016;134(6):32–69.CrossRef Page RL 2nd, O'Bryant CL, Cheng D, Dow TJ, Ky B, Stein CM, et al. Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association. Circulation. 2016;134(6):32–69.CrossRef
26.
go back to reference Hungarian National Committee of pharmaceutical care. Metabolic syndrome pharmaceutical care Programme. 2009. Hungarian National Committee of pharmaceutical care. Metabolic syndrome pharmaceutical care Programme. 2009.
28.
go back to reference Regulation no 44/2004 MoHSFA on the ordering and issuing of medicinal products for human use. Sect. 22/A-C (2004). Regulation no 44/2004 MoHSFA on the ordering and issuing of medicinal products for human use. Sect. 22/A-C (2004).
30.
go back to reference Act XLVII of 1997 on the management and protection of health data and related personal data, XLVII. Sect. 14/A (1997). Act XLVII of 1997 on the management and protection of health data and related personal data, XLVII. Sect. 14/A (1997).
31.
go back to reference Regulation No 41/2007 Ministry for Health on the operation, Service and registration of public, branch, manual and institute pharmacies. Sect. 36/A (2007). Regulation No 41/2007 Ministry for Health on the operation, Service and registration of public, branch, manual and institute pharmacies. Sect. 36/A (2007).
32.
go back to reference Act CLIV of 1997 on Health, CLIV Sect 15 (1997). Act CLIV of 1997 on Health, CLIV Sect 15 (1997).
33.
go back to reference Jiron M, Herrada L, Rojas A, Lueiza A, Vega E, Buckel E, et al. Prevalence of potentially inappropriate medication prescribing among older adults in emergency Department in Chile, vol. 24; 2015. p. 102. Jiron M, Herrada L, Rojas A, Lueiza A, Vega E, Buckel E, et al. Prevalence of potentially inappropriate medication prescribing among older adults in emergency Department in Chile, vol. 24; 2015. p. 102.
Metadata
Title
Qualitative and quantitative research of medication review and drug-related problems in Hungarian community pharmacies: a pilot study
Authors
András Szilvay
Orsolya Somogyi
Attiláné Meskó
Romána Zelkó
Balázs Hankó
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Care
Published in
BMC Health Services Research / Issue 1/2019
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-019-4114-1

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