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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2019

Open Access 01-12-2019 | Research article

The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats

Authors: Feng Wan, Ru-chun Yang, Yan-peng Shi, Yue-Wen Tang, Xuan-li Tang, Xiao-ling Zhu, You-gui Li, Yong-jun Wang

Published in: BMC Complementary Medicine and Therapies | Issue 1/2019

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Abstract

Background

This study aimed to investigate the effect of the Phellinus linteus (Mesima) decoction on podocyte injury in a rat model of focal and segmental glomerulosclerosis (FSGS) and evaluate the potential mechanisms.

Methods

FSGS resembling primary FSGS in humans was established in rats by uninephrectomy and the repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, low-dose group of P. linteus decoction (PLD-LD), medium-dose group of P. linteus decoction (PLD-MD), and high-dose group of P. linteus decoction (PLD-HD). Blood and urine analysis were performed after 12 weeks and the molecular indicators of renal function and the renal pathological changes were examined.

Results

FSGS developed within 12 weeks in the test group and showed progressive proteinuria and segmental glomerular scarring. Urinary protein, serum creatinine, urea nitrogen, triglycerides and cholesterol were significantly reduced following the 12-week intervention with P.linteus decoction, especially in the PLD-LD group. Renal nephrin and podocin were markedly increased. Moreover, the pathological damage in the renal tissue was alleviated by the PLD-LD intervention.

Conclusion

The P. linteus decoction alleviated the podocyte injury in the FSGS rat model, thus minimizing the progression of glomerular sclerosis and improving renal function.
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Metadata
Title
The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats
Authors
Feng Wan
Ru-chun Yang
Yan-peng Shi
Yue-Wen Tang
Xuan-li Tang
Xiao-ling Zhu
You-gui Li
Yong-jun Wang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2019
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-019-2705-3

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