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Published in: BMC Complementary Medicine and Therapies 1/2019

Open Access 01-12-2019 | Research article

Heavy metal content of herbal health supplement products in Dubai – UAE: a cross-sectional study

Authors: Naseem Mohammed Abdulla, Balazs Adam, Iain Blair, Abderrahim Oulhaj

Published in: BMC Complementary Medicine and Therapies | Issue 1/2019

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Abstract

Background

Lead, mercury, cadmium, chromium, and arsenic intoxication have been associated with the use of health supplement (HS) products. The aim of this study is to estimate the concentration of heavy metals in HS products that are on sale in Dubai, United Arab Emirates, premises and to compare estimated daily metal intake with regulatory standards.

Methods

Dubai-area premises selling HS products were identified by searching the Dubai Municipality database to identify all pharmacies, para-pharmacies and nutrition and healthcare shops. A total of 859 premises were identified in the Deira and Bur-Dubai areas. Data collection was performed between September 1 and December 12, 2016. During that period, all premises that had been identified within Dubai were visited and samples for laboratory testing were collected.

Results

A total of 200 HS products were tested for lead, mercury, cadmium, chromium and arsenic. High proportion of samples were found to contain metals less than the limits of the detection (LOD) of the method. It was found that 93% of products contained Arsenic (As) < LOD, 94.5% of lead (Pb) < LOD, 100% of Cadmium (Cd) < LOD, 99% of Mercury (Hg) < LOD and 23.5% of Chromium (Cr) < LOD. Using the single imputation method to account for LOD, estimates for the average daily intake of lead was 0.88 μg compared to the tolerable daily intake (TDI) of 20 μg, daily intake of mercury was 0.09 μg (TDI = 20 μg), daily intake of cadmium was 0.83 μg (TDI = 6 μg) while for arsenic it was 0.92 μg compared to the tolerable daily intake of 10 μg. The average daily intake of chromium was 7.57 μg with no internationally established TDI. Assuming users followed the manufacturers’ instructions, daily intake of arsenic, lead and mercury would not exceed TDI for any of the 200 products. However, the daily intake of cadmium exceeded or approximated the TDI for three products.

Conclusions

In this study we found low levels of metals in the products that were available for sale in Dubai. With few exceptions, if the products were used according to the suppliers’ instructions, average daily intake of heavy metals will be well below the recommended tolerable daily intakes.
Literature
1.
go back to reference Phua DH, Zosel A, Heard K. Dietary supplements and herbal medicine toxicities—when to anticipate them and how to manage them. Int J Emerg Med. 2009;2(2):69–76.CrossRef Phua DH, Zosel A, Heard K. Dietary supplements and herbal medicine toxicities—when to anticipate them and how to manage them. Int J Emerg Med. 2009;2(2):69–76.CrossRef
4.
go back to reference Gahche J, Bailey R, Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988–1994). NCHS Data Brief. 2011;61:1–8. Gahche J, Bailey R, Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988–1994). NCHS Data Brief. 2011;61:1–8.
6.
go back to reference Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol. 2015;55(6):515–25.CrossRef Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol. 2015;55(6):515–25.CrossRef
7.
go back to reference Mamtani R, Cheema S, MacRae B, et al. Herbal and nutritional supplement use among college students in Qatar. East Mediterr Health J. 2015;21(1):39–44.CrossRef Mamtani R, Cheema S, MacRae B, et al. Herbal and nutritional supplement use among college students in Qatar. East Mediterr Health J. 2015;21(1):39–44.CrossRef
8.
go back to reference Woo JY. Adverse event monitoring and multivitamin-multimineral dietary supplements. Am J Clin Nutr. 2007;85(1):323–4.CrossRef Woo JY. Adverse event monitoring and multivitamin-multimineral dietary supplements. Am J Clin Nutr. 2007;85(1):323–4.CrossRef
10.
go back to reference Ching CK, Lam YH, Albert Y, et al. Adulteration of herbal ant diabetic products with undeclared pharmaceuticals: a case series in Hong Kong. Br J Clin Pharmacol. 2011;73(5):795–800.CrossRef Ching CK, Lam YH, Albert Y, et al. Adulteration of herbal ant diabetic products with undeclared pharmaceuticals: a case series in Hong Kong. Br J Clin Pharmacol. 2011;73(5):795–800.CrossRef
11.
go back to reference Prakash O, Kumar A, Kumar P, et al. Adulteration and substitution of Indian medicinal plants: an overview. J Med Plants Stud. 2013;1:127–32. Prakash O, Kumar A, Kumar P, et al. Adulteration and substitution of Indian medicinal plants: an overview. J Med Plants Stud. 2013;1:127–32.
12.
go back to reference Leung KS, Chan K, Chan C, et al. Systematic evaluation of Organochlorine pesticide residues in Chinese Materia Medica. Phytother Res. 2005;19(6):514–8.CrossRef Leung KS, Chan K, Chan C, et al. Systematic evaluation of Organochlorine pesticide residues in Chinese Materia Medica. Phytother Res. 2005;19(6):514–8.CrossRef
14.
go back to reference Khan S, Cao Q, Zheng YM, et al. Health risks of heavy metals in contaminated soils and food crops irrigated with waste water in Beijing. China Environ Pollut. 2008;152(3):686–92.CrossRef Khan S, Cao Q, Zheng YM, et al. Health risks of heavy metals in contaminated soils and food crops irrigated with waste water in Beijing. China Environ Pollut. 2008;152(3):686–92.CrossRef
15.
go back to reference Bentum JK, Adotey JPK, Koka J, et al. Assessment of lead, copper and zinc contamination of soil from University of Cape Coast School of agricultural farmland. Ghana IJBCS. 2011;5(4):1703–11. Bentum JK, Adotey JPK, Koka J, et al. Assessment of lead, copper and zinc contamination of soil from University of Cape Coast School of agricultural farmland. Ghana IJBCS. 2011;5(4):1703–11.
16.
go back to reference Obi E, Johnson AO, Orisakwe OE. Testicular toxicity of B-success herbal supplement in male albino rats. IRJPP. 2011;1(8):221–7. Obi E, Johnson AO, Orisakwe OE. Testicular toxicity of B-success herbal supplement in male albino rats. IRJPP. 2011;1(8):221–7.
17.
go back to reference Fasinu PS, Orisakwe OE. Heavy metal pollution in sub-Saharan Africa and possible implications in Cancer epidemiology. Asian Pac J Cancer Prev. 2013;14(6):3393–401.CrossRef Fasinu PS, Orisakwe OE. Heavy metal pollution in sub-Saharan Africa and possible implications in Cancer epidemiology. Asian Pac J Cancer Prev. 2013;14(6):3393–401.CrossRef
20.
go back to reference Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53(282):457–81.CrossRef Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53(282):457–81.CrossRef
21.
go back to reference Kim H, Hughes PJ, Hawes EM. Adverse events associated with metal contamination of traditional Chinese medicines in Korea: a clinical review. Yonsei Med J. 2014;55(5):1177–86.CrossRef Kim H, Hughes PJ, Hawes EM. Adverse events associated with metal contamination of traditional Chinese medicines in Korea: a clinical review. Yonsei Med J. 2014;55(5):1177–86.CrossRef
22.
go back to reference Houston MC. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern Ther Health and Med. 2007;13(2):S128–33. Houston MC. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Altern Ther Health and Med. 2007;13(2):S128–33.
Metadata
Title
Heavy metal content of herbal health supplement products in Dubai – UAE: a cross-sectional study
Authors
Naseem Mohammed Abdulla
Balazs Adam
Iain Blair
Abderrahim Oulhaj
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2019
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-019-2693-3

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