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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2019

Open Access 01-12-2019 | Metastasis | Research article

The modified Si-Jun-Zi Decoction attenuates colon cancer liver metastasis by increasing macrophage cells

Authors: Jin-Yong Zhou, Min Chen, Cun-En Wu, Yu-Wen Zhuang, Yu-Gen Chen, Shen-Lin Liu

Published in: BMC Complementary Medicine and Therapies | Issue 1/2019

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Abstract

Background

The modified Si-Jun-Zi Decoction (SJZ), a Chinese medicine formula, is clinically used against multiple malignancies including colorectal cancer (CRC). This study aims to evaluate the effect of modified SJZ on CRC liver metastasis and identify the therapeutic mechanisms.

Methods

Human CRC cells with GFP fluorescence were transplanted into Balb/c nude mice spleens. Modified SJZ, 5-fluorouracil or the combined treatment was given for 3 weeks. CRC liver metastasis was measured by fluorescence imaging and plasma cytokines were analyzed. Furthermore, the effects of administration time and doses for the modified SJZ were investigated in nude mice.

Results

Modified SJZ could increase the survival rate and reduce CRC liver metastasis in the nude mice model. Plasma GM-CSF level was elevated. Three weeks of treatment with the modified SJZ at the full dose (45 g/kg) could significantly increase the number of macrophages but not neutrophils in the spleen.

Conclusions

These results indicate that modified SJZ can inhibit CRC liver metastasis by activating the innate immune system, providing a complementary and alternative therapy for CRC.
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Metadata
Title
The modified Si-Jun-Zi Decoction attenuates colon cancer liver metastasis by increasing macrophage cells
Authors
Jin-Yong Zhou
Min Chen
Cun-En Wu
Yu-Wen Zhuang
Yu-Gen Chen
Shen-Lin Liu
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2019
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-019-2498-4

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