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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2019

Open Access 01-12-2019 | Osteoporosis | Research article

Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study

Authors: Yu-Chi Wang, Jen-Huai Chiang, Hsin-Cheng Hsu, Chun-Hao Tsai

Published in: BMC Complementary Medicine and Therapies | Issue 1/2019

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Abstract

Background

There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.

Methods

We identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year. The difference between the two groups in the development of fracture was estimated using the Kaplan–Meier method and the log-rank test.

Results

After inserting age, gender, urbanization level, and comorbidities into the Cox’s proportional hazard model, patients who used TCM had a lower hazard ratio (HR) of fracture (adjusted HR: 0.47, 95% CI: 0.37–0.59) compared to the non-TCM user group. The Kaplan-Meier curves showed that osteoporosis patients who used TCM had a lower incidence of fracture events than those who did not (p < 0.00001). Our study also demonstrated that the longer the TCM use, the lesser the fracture rate.

Conclusion

Our study showed that TCM might have a positive impact on the prevention of osteoporotic fracture.
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Metadata
Title
Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study
Authors
Yu-Chi Wang
Jen-Huai Chiang
Hsin-Cheng Hsu
Chun-Hao Tsai
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2019
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-019-2446-3

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