Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2017

Open Access 01-12-2017 | Research article

The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats

Authors: Xiao Yu, Xiao-Dong Zhao, Rong-Qi Bao, Jia-Yu Yu, Guo-Xing Zhang, Jing-Wei Chen

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

Login to get access

Abstract

Background

To investigate the effects and involved mechanisms of the modified Yi Qi decoction (MYQ) in cardiac ischemia-reperfusion (IR) induced injury.

Methods

Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by reperfusion, low or high dose decoction of MYQ was administrated orally for 1 week or 1 month.

Results

Both in 1 week and 1 month IR rat groups, cardiac function indexes were significantly impaired compared with sham group rats, accompanied with higher ratio of infarct size to risk size, decreased expressions of sodium calcium exchanger (NCX1) and sarcoplasmic reticulum Ca2+-ATPase (Serca2a), and different expressions of autophagic proteins, Beclin-1 and LC3. Treatment with MYQ (low or high dose) for 1 week showed no marked beneficial effects on cardiac function and cardiac injury (ratio of infarct size to risk size), although expressions of anti-apoptotic protein, Bcl-2, NCX1 and Serca2a were increased. Treatment with MYQ (low or high dose) for 1 month showed significantly improved effects on cardiac function and cardiac injury (ratio of infarct size to risk size), accompanied with increase of Bcl-2, NCX1 and Serca2a expressions, and decrease of Bax (a pro-apoptotic protein) and Beclin-1 expressions.

Conclusions

The results show that MYQ have potential therapeutic effects on IR-induced cardiac injury, which may be through regulation of apoptotic proteins, cytosolic Ca2+ handling proteins and autophagic proteins signal pathways.
Literature
1.
Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER, 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S: Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation 2015, 131:e29–322.
2.
3.
4.
5.
Jordan JE, Zhao ZQ, Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res. 1999;43:860–78.CrossRefPubMed
6.
Fauconnier J, Roberge S, Saint N, Lacampagne A. Type 2 ryanodine receptor: a novel therapeutic target in myocardial ischemia/reperfusion. Pharmacol Ther. 2013;138:323–32.CrossRefPubMed
7.
Liu Q, Li J, Wang J, Li J, Janicki JS, Fan D. Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury. Evidence-based Complementary and Alternative Medicine: eCAM. 2013;2013:925625.
8.
Zhao FD, Dong JC, Xie JY: [Effects of Chinese herbs for replenishing shen and strengthening qi on some indexes of neuro-endocrino-immune network in asthmatic rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine/Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 2007, 27:715–9.
9.
Jiang D, Wang X, Su Q, Jiang S, Yuan F, Zhang C, et al. Milkvetch root improves immune function in patients with acute exacerbation of COPD. Biomed Mater Eng. 2015;26(Suppl 1):S2113–21.PubMed
10.
Meng D, Chen XJ, Bian YY, Li P, Yang D, Zhang JN. Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats. The American Journal of Chinese Medicine. 2005;33:11–20.CrossRefPubMed
11.
Xu XL, Chen XJ, Ji H, Li P, Bian YY, Yang D, et al. Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum ca-ATPase. Pharmacology. 2008;81:325–32.CrossRefPubMed
12.
Wang Y, Ji Y, Xing Y, Li X, Gao X. Astragalosides rescue both cardiac function and sarcoplasmic reticulum ca(2)(+) transport in rats with chronic heart failure. Phytotherapy Research: PTR. 2012;26:231–8.CrossRefPubMed
13.
Li JH, Du GJ, Liu WJ, Liu YH, Zhao B, Li H. [study on anti-tumor and anti-metastasis mechanism of alcohol extracts from pharbitidis semen against Lewis lung cancer]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi =. China Journal of Chinese Materia Medica. 2014;39:879–84.PubMed
14.
Feize W, Meng L, Yanni L, Yuan L, Liqun J, Tong L, et al. A randomized controlled study to observe the efficacy of external treatment with a traditional Chinese medicine herbal ointment on malignant plural effusion: outcome report and design review. Integrative Cancer Therapies. 2016;
15.
Fang RC, Tsai YT, Lai JN, Yeh CH, Wu CT. The traditional chinese medicine prescription pattern of endometriosis patients in taiwan: a population-based study. Evidence-based Complementary and Alternative Medicine: eCAM. 2012;2012:591391.
16.
Yen HR, Chen YY, Huang TP, Chang TT, Tsao JY, Chen BC, et al. Prescription patterns of Chinese herbal products for patients with uterine fibroid in Taiwan: a nationwide population-based study. J Ethnopharmacol. 2015;171:223–30.CrossRefPubMed
17.
Lin GM, Chen YH, Yen PL, Chang ST. Antihyperglycemic and antioxidant activities of twig extract from Cinnamomum osmophloeum. Journal of Traditional and Complementary Medicine. 2016;6:281–8.CrossRefPubMed
18.
Feng S, Song L, Liu Y, Lai F, Zuo G, He G, et al. Hypoglycemic activities of commonly-used traditional Chinese herbs. The American journal of Chinese Medicine. 2013;41:849–64.CrossRefPubMed
19.
Guo DJ, Cheng HL, Chan SW, Yu PH. Antioxidative activities and the total phenolic contents of tonic Chinese medicinal herbs. Inflammopharmacology. 2008;16:201–7.CrossRefPubMed
20.
Choi HG, Je IG, Kim GJ, Choi H, Kim SH, Kim JA, et al. Anti-allergic inflammatory activities of compounds of amomi fructus. Nat Prod Commun. 2015;10:631–2.PubMed
21.
Yeh LL, Liu JY, Liu YS, Lin KS, Tsai TF, Wang LH. Anemia-related hemogram, uterine artery pulsatility index, and blood pressure for the effects of four-agents-decoction (Si Wu tang) in the treatment of primary dysmenorrhea. J Altern Complement Med. 2009;15:531–8.CrossRefPubMed
22.
Wang Z, Shen L, Li X, Shu X, Shan B, Zhang L, et al. Painrelieving effect of a compound isolated from white peony root oral liquid on acute radiationinduced esophagitis. Mol Med Rep. 2013;7:1950–4.PubMed
23.
Jin X, Zhang Y, Li Q, Zhao J. Mechanisms underlying the beneficial effects of Kaiyu granule for depression. Neural Regen Res. 2013;8:3241–8.PubMedPubMedCentral
24.
Feng L, Liu WK, Deng L, Tian JX, Tong XL: Clinical efficacy of aconitum-containing traditional Chinese medicine for diabetic peripheral neuropathic pain. The American Journal of Chinese Medicine 2014, 42:109–117.
25.
Yin HQ, Wang B, Zhang JD, Lin HQ, Qiao Y, Wang R, et al. Effect of traditional Chinese medicine Shu-Mai-tang on attenuating TNFalpha-induced myocardial fibrosis in myocardial ischemia rats. J Ethnopharmacol. 2008;118:133–9.CrossRefPubMed
26.
Mak DH, Chiu PY, Dong TT, Tsim KW, Ko KM. Dang-Gui Buxue tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytotherapy Research: PTR. 2006;20:561–7.CrossRefPubMed
27.
Yin H, Zhang J, Lin H, Qiao Y, Wang R, Lu H, et al. Effect of traditional Chinese medicine Shu-mai-tang on angiogenesis, arteriogenesis and cardiac function in rats with myocardial ischemia. Phytotherapy Research: PTR. 2009;23:92–8.CrossRefPubMed
28.
Wang XY, Qin F, Huang X, Zhang XY, Ren P, Zhao HW. [effects of Dan-Chuan-Hong decoction on myocardial apoptosis of acute myocardial ischemia in rats]. Zhong yao cai = Zhongyaocai =. Journal of Chinese Medicinal Materials. 2009;32:725–8.PubMed
29.
Chiu PY, Wong SM, Leung HY, Leong PK, Chen N, Zhou L, et al. Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCvarepsilon/mK(ATP) pathway in rats. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2011;18:916–25.CrossRef
30.
Chiu PY, Leung HY, Leong PK, Chen N, Zhou L, Zuo Z, et al. Danshen-Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCepsilon/mKATP pathways in H9c2 cardiomyocytes. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2012;19:99–110.CrossRef
31.
Zhang GX, Kimura S, Murao K, Obata K, Matsuyoshi H, Takaki M. Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia-reperfusion in the rat. Am J Phys Heart Circ Phys. 2010;298:H433–9.
32.
Scarfo L, Ghia P. Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunol Lett. 2013;155:36–9.CrossRefPubMed
33.
Mirzayans R, Andrais B, Kumar P, Murray D. The growing complexity of cancer cell response to DNA-damaging agents: caspase 3 mediates cell death or survival? Int J Mol Sci. 2016;17
34.
La Rovere RM, Roest G, Bultynck G, Parys JB. Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy. Cell Calcium. 2016;
35.
Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, et al. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation. 2012;125:3170–81.CrossRefPubMedPubMedCentral
36.
Chiong M, Wang ZV, Pedrozo Z, Cao DJ, Troncoso R, Ibacache M, et al. Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis. 2011;2:e244.CrossRefPubMedPubMedCentral
37.
Liu Y, Lin R, Zhang H, Zhang JY, Ji QL, Yang YJ: [Protective effect of Buyanghuanwu Decoction on myocardial ischemia induced by isoproterenol in rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2009, 32:380–3.
38.
Han R, Tang F, Lu M, Xu C, Hu J, Mei M, et al. Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol. Int Immunopharmacol. 2016;38:306–12.CrossRefPubMed
39.
Dun C, Liu J, Qiu F, Wu X, Wang Y, Zhao Y, et al. Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model. Neuropsychiatr Dis Treat. 2016;12:1617–21.CrossRefPubMedPubMedCentral
40.
Yi YE, Li SY, Nie YN, Jia DX, Zhang ZH, Wang YF, et al. Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice. BMC Complement Altern Med. 2016;16:222.CrossRefPubMedPubMedCentral
41.
Wang SF, Wang Q, Jiao LJ, Huang YL, Garfield D, Zhang J, et al. Astragalus-containing traditional Chinese medicine, with and without prescription based on syndrome differentiation, combined with chemotherapy for advanced non-small-cell lung cancer: a systemic review and meta-analysis. Curr Oncol. 2016;23:e188–95.CrossRefPubMedPubMedCentral
42.
Ma C, Bi K, Zhang M, Su D, Fan X, Ji W, et al. Toxicology effects of morning glory seed in rat: a metabonomic method for profiling of urine metabolic changes. J Ethnopharmacol. 2010;130:134–42.CrossRefPubMed
43.
Tsai JC, Tsai S, Chang WC. Comparison of two Chinese medical herbs, Huangbai and Qianniuzi, on influence of short circuit current across the rat intestinal epithelia. J Ethnopharmacol. 2004;93:21–5.CrossRefPubMed
44.
Lee TH, Choi JJ, Kim DH, Choi S, Lee KR, Son M, et al. Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis semen and corydalis tuber. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2008;15:836–43.CrossRef
45.
Kim KH, Ha SK, Choi SU, Kim SY, Lee KR. Bioactive phenolic constituents from the seeds of Pharbitis nil. Chemical & Pharmaceutical Bulletin. 2011;59:1425–9.CrossRef
46.
Wang Q, Sun Y, Yang B, Wang Z, Liu Y, Cao Q, et al. Optimization of polysaccharides extraction from seeds of Pharbitis nil and its anti-oxidant activity. Carbohydr Polym. 2014;102:460–6.CrossRefPubMed
47.
Tung YT, Chua MT, Wang SY, Chang ST. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol. 2008;99:3908–13.CrossRefPubMed
48.
Kumar G, Chauhan B, Ali M. Isolation and identification of new phytoconstituents from the fruit extract of Amomum Subulatum Roxb. Nat Prod Res. 2014;28:127–33.CrossRefPubMed
49.
Jafri MA. Farah, Javed K, Singh S: evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum Subulatum Roxb). J Ethnopharmacol. 2001;75:89–94.CrossRefPubMed
50.
Wang JH, Shin JW, Choi MK, Kim HG, Son CG. An herbal fruit, Amomum Xanthoides, ameliorates thioacetamide-induced hepatic fibrosis in rat via antioxidative system. J Ethnopharmacol. 2011;135:344–50.CrossRefPubMed
51.
Zhu Y, Wang L, Yang Z, Wang J, Li W, Zhou J, et al. Hematopoietic effects of Paeoniflorin and Albiflorin on radiotherapy-induced myelosuppression mice. Evidence-based Complementary and Alternative Medicine. 2016;2016:5789381.PubMedPubMedCentral
52.
Shen L, Li X, Shan B, Zhang L, Gong Y, Dong Z, et al. Therapeutic effect of compound of white Peony root oral liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-beta1. Biomedical Reports. 2013;1:308–14.PubMed
53.
Wang Z, Shen L, Wang J, Shan B, Zhang L, Lu F, et al. Immunostimulatory effect of a composition isolated from white peony root oral liquid in the treatment of radiation-induced esophagitis. Experimental and Therapeutic Medicine. 2013;6:1010–4.PubMedPubMedCentral
54.
Hausenloy DJ, Yellon DM. Ischaemic conditioning and reperfusion injury. Nat Rev Cardiol. 2016;13:193–209.CrossRefPubMed
55.
Bulluck H, Yellon DM, Hausenloy DJ. Reducing myocardial infarct size: challenges and future opportunities. Heart. 2016;102:341–8.CrossRefPubMed
56.
57.
Bagai A, Dangas GD, Stone GW, Granger CB. Reperfusion strategies in acute coronary syndromes. Circ Res. 2014;114:1918–28.CrossRefPubMed
58.
Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol. 2010;72:19–44.CrossRefPubMed
59.
Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006;281:29776–87.CrossRefPubMed
Metadata
Title
The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats
Authors
Xiao Yu
Xiao-Dong Zhao
Rong-Qi Bao
Jia-Yu Yu
Guo-Xing Zhang
Jing-Wei Chen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-017-1829-6

Other articles of this Issue 1/2017

BMC Complementary Medicine and Therapies 1/2017 Go to the issue

Research article

IL-1β-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties

Research article

Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial

Software

DisArticle: a web server for SVM-based discrimination of articles on traditional medicine

Research article

Flavonolignans inhibit the arachidonic acid pathway in blood platelets

Research article

In vivo screening and evaluation of four herbs against MRSA infections

Research article

ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs