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Published in: BMC Complementary Medicine and Therapies 1/2017

Open Access 01-12-2017 | Research article

An interpretive review of consensus statements on clinical guideline development and their application in the field of traditional and complementary medicine

Authors: Jennifer Hunter, Matthew Leach, Lesley Braun, Alan Bensoussan

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

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Abstract

Background

Despite ongoing consumer demand and an emerging scientific evidence-base for traditional and complementary medicine (T&CM), there remains a paucity of reliable information in standard clinical guidelines about their use. Often T&CM interventions are not mentioned, or the recommendations arising from these guidelines are unhelpful to end-users (i.e. patients, practitioners and policy makers). Insufficient evidence of efficacy may be a contributing factor; however, often informative recommendations could still be made by drawing on relevant information from other avenues. In light of this, the aim of this research was to review national and internationally endorsed consensus statements for clinical guideline developers, and to interpret how to apply these methods when making recommendations regarding the use of T&CM.

Method

The critical interpretive review method was used to identify and appraise relevant consensus statements published between 1995 and 2015. The statements were identified using a purposive sampling technique until data saturation was reached. The most recent edition of a statement was included in the analysis. The content, scope and themes of the statements were compared and interpreted within the context of the T&CM setting; including history, regulation, use, emerging scientific evidence-base and existing guidelines.

Results

Eight consensus statements were included in the interpretive review. Searching stopped at this stage as no new major themes were identified. The five themes relevant to the challenges of developing T&CM guidelines were: (1) framing the question; (2) the limitations of using an evidence hierarchy; (3) strategies for dealing with insufficient, high quality evidence; (4) the importance of qualifying a recommendation; and (5) the need for structured consensus development.

Conclusion

Evidence regarding safety, efficacy and cost effectiveness are not the only information required to make recommendations for clinical guidelines. Modifying factors such as burden of disease, magnitude of effect, current use, demand, equity and ease of integration should also be considered. Uptake of the recommendations arising from this review are expected to result in the development of higher quality clinical guidelines that offer greater assistance to those seeking answers about the appropriate use of T&CM.
Literature
1.
go back to reference Ooi SL, Rae J, Pak SC. Implementation of evidence-based practice: A naturopath perspective. Complement Ther Clin Pract. 2016;22:24–8.CrossRefPubMed Ooi SL, Rae J, Pak SC. Implementation of evidence-based practice: A naturopath perspective. Complement Ther Clin Pract. 2016;22:24–8.CrossRefPubMed
2.
go back to reference Leach MJ. Clinical decision making in complementary and alternative medicine. Sydney: Churchill Livingstone; 2010. Leach MJ. Clinical decision making in complementary and alternative medicine. Sydney: Churchill Livingstone; 2010.
3.
go back to reference Field MJ, Lohr KN. Clinical practice guidelines: directions for a new program. Washington: National Academy Press; 1990. Field MJ, Lohr KN. Clinical practice guidelines: directions for a new program. Washington: National Academy Press; 1990.
4.
go back to reference Truman BI, Smith-Akin CK, Hinman AR, Gebbie KM, Brownson R, Novick LF, Lawrence RS, Pappaioanou M, Fielding J, Evans Jr CA, et al. Developing the Guide to Community Preventive Services--overview and rationale. The Task Force on Community Preventive Services. Am J Prev Med. 2000;18(1 Suppl):18–26.CrossRefPubMed Truman BI, Smith-Akin CK, Hinman AR, Gebbie KM, Brownson R, Novick LF, Lawrence RS, Pappaioanou M, Fielding J, Evans Jr CA, et al. Developing the Guide to Community Preventive Services--overview and rationale. The Task Force on Community Preventive Services. Am J Prev Med. 2000;18(1 Suppl):18–26.CrossRefPubMed
5.
go back to reference Woolf SH, DiGuiseppi CG, Atkins D, Kamerow DB. Developing evidence-based clinical practice guidelines: lessons learned by the US Preventive Services Task Force. Annu Rev Public Health. 1996;17:511–38.CrossRefPubMed Woolf SH, DiGuiseppi CG, Atkins D, Kamerow DB. Developing evidence-based clinical practice guidelines: lessons learned by the US Preventive Services Task Force. Annu Rev Public Health. 1996;17:511–38.CrossRefPubMed
7.
go back to reference WHO. Guidelines for WHO guidelines. Geneva: World Health Organisation; 2003. p. 46. WHO. Guidelines for WHO guidelines. Geneva: World Health Organisation; 2003. p. 46.
8.
go back to reference Eccles M, Mason J. How to develop cost-conscious guidelines. Health Technol Assess. 2001;5(16):1–69.CrossRefPubMed Eccles M, Mason J. How to develop cost-conscious guidelines. Health Technol Assess. 2001;5(16):1–69.CrossRefPubMed
9.
go back to reference Woolf S, Schunemann HJ, Eccles MP, Grimshaw JM, Shekelle P. Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations. Implement Sci. 2012;7:61.CrossRefPubMedPubMedCentral Woolf S, Schunemann HJ, Eccles MP, Grimshaw JM, Shekelle P. Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations. Implement Sci. 2012;7:61.CrossRefPubMedPubMedCentral
10.
go back to reference Edejer TT. Improving the use of research evidence in guideline development: 11. Incorporating considerations of cost-effectiveness, affordability and resource implications. Health Res Policy Syst. 2006;4:23.CrossRefPubMedPubMedCentral Edejer TT. Improving the use of research evidence in guideline development: 11. Incorporating considerations of cost-effectiveness, affordability and resource implications. Health Res Policy Syst. 2006;4:23.CrossRefPubMedPubMedCentral
11.
go back to reference NHMRC. Review of the Australian Government Rebate on Natural Therapies for Private Health Insurance. Canberra: Commonwealth of Australia; 2015. NHMRC. Review of the Australian Government Rebate on Natural Therapies for Private Health Insurance. Canberra: Commonwealth of Australia; 2015.
12.
go back to reference Brouwers M, Kho ME, Browman GP, Cluzeau F, feder G, Fervers B, Hanna S, Makarski J on behalf of the AGREE Next Steps Consortium. AGREE II Instrument: Advancing guideline development, reporting and evaluation in healthcare. The AGREE Research Trust, May 2009, UPDATE: September 2013. [http://www.agreetrust.org/]. Accessed 1 Sept 2014. Brouwers M, Kho ME, Browman GP, Cluzeau F, feder G, Fervers B, Hanna S, Makarski J on behalf of the AGREE Next Steps Consortium. AGREE II Instrument: Advancing guideline development, reporting and evaluation in healthcare. The AGREE Research Trust, May 2009, UPDATE: September 2013. [http://​www.​agreetrust.​org/​]. Accessed 1 Sept 2014.
13.
go back to reference Semlitsch T, Blank WA, Kopp IB, Siering U, Siebenhofer A. Evaluating Guidelines: A Review of Key Quality Criteria. Dtsch Arztebl Int. 2015;112(27–28):471–8.PubMedPubMedCentral Semlitsch T, Blank WA, Kopp IB, Siering U, Siebenhofer A. Evaluating Guidelines: A Review of Key Quality Criteria. Dtsch Arztebl Int. 2015;112(27–28):471–8.PubMedPubMedCentral
14.
go back to reference Ernst E. Assessments of complementary and alternative medicine: the clinical guidelines from NICE. Int J Clin Pract. 2010;64(10):1350–8.CrossRefPubMed Ernst E. Assessments of complementary and alternative medicine: the clinical guidelines from NICE. Int J Clin Pract. 2010;64(10):1350–8.CrossRefPubMed
15.
16.
go back to reference Lorenc A, Leach J, Robinson N. Clinical guidelines in the UK: Do they mention Complementary and alternative medicine (CAM) – Are CAM professional bodies aware? Eur J Intern Med. 2014;6(2):164–75.CrossRef Lorenc A, Leach J, Robinson N. Clinical guidelines in the UK: Do they mention Complementary and alternative medicine (CAM) – Are CAM professional bodies aware? Eur J Intern Med. 2014;6(2):164–75.CrossRef
17.
go back to reference Robinson N, Lui J, Lee MS. Clinical guidelines: The way for best practice. Eur J Intern Med. 2014;6(2):133–4.CrossRef Robinson N, Lui J, Lee MS. Clinical guidelines: The way for best practice. Eur J Intern Med. 2014;6(2):133–4.CrossRef
18.
go back to reference Andrews JC, Schunemann HJ, Oxman AD, Pottie K, Meerpohl JJ, Coello PA, Rind D, Montori VM, Brito JP, Norris S, et al. GRADE guidelines: 15. Going from evidence to recommendation: determinants of a recommendation's direction and strength. J Clin Epidemiol. 2013;66(7):726–35.CrossRefPubMed Andrews JC, Schunemann HJ, Oxman AD, Pottie K, Meerpohl JJ, Coello PA, Rind D, Montori VM, Brito JP, Norris S, et al. GRADE guidelines: 15. Going from evidence to recommendation: determinants of a recommendation's direction and strength. J Clin Epidemiol. 2013;66(7):726–35.CrossRefPubMed
19.
go back to reference Andrews J, Guyatt G, Oxman AD, Alderson P, Dahm P, Falck-Ytter Y, Nasser M, Meerpohl J, Post PN, Kunz R, et al. GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol. 2013;66(7):719–25.CrossRefPubMed Andrews J, Guyatt G, Oxman AD, Alderson P, Dahm P, Falck-Ytter Y, Nasser M, Meerpohl J, Post PN, Kunz R, et al. GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol. 2013;66(7):719–25.CrossRefPubMed
20.
go back to reference Oxman AD, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 17: Dealing with insufficient research evidence. Health Res Policy Syst. 2009;7 Suppl 1:S17.CrossRefPubMed Oxman AD, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 17: Dealing with insufficient research evidence. Health Res Policy Syst. 2009;7 Suppl 1:S17.CrossRefPubMed
21.
go back to reference Petitti DB, Teutsch SM, Barton MB, Sawaya GF, Ockene JK, DeWitt T. Update on the methods of the U.S. Preventive Services Task Force: insufficient evidence. Ann Intern Med. 2009;150(3):199–205.CrossRefPubMed Petitti DB, Teutsch SM, Barton MB, Sawaya GF, Ockene JK, DeWitt T. Update on the methods of the U.S. Preventive Services Task Force: insufficient evidence. Ann Intern Med. 2009;150(3):199–205.CrossRefPubMed
22.
go back to reference Walach H, Falkenberg T, Fonnebo V, Lewith G, Jonas WB. Circular instead of hierarchical: methodological principles for the evaluation of complex interventions. BMC Med Res Methodol. 2006;6:29.CrossRefPubMedPubMedCentral Walach H, Falkenberg T, Fonnebo V, Lewith G, Jonas WB. Circular instead of hierarchical: methodological principles for the evaluation of complex interventions. BMC Med Res Methodol. 2006;6:29.CrossRefPubMedPubMedCentral
23.
go back to reference Walach H, Loef M. Using a matrix-analytical approach to synthesising evidence solved incompatibility problem in the Hierarchy of Evidence. J Clin Epidemiol. 2015. Walach H, Loef M. Using a matrix-analytical approach to synthesising evidence solved incompatibility problem in the Hierarchy of Evidence. J Clin Epidemiol. 2015.
24.
go back to reference Greenhalgh T, Howick J, Maskrey N. Evidence based medicine: a movement in crisis? BMJ. 2014;13:348. Greenhalgh T, Howick J, Maskrey N. Evidence based medicine: a movement in crisis? BMJ. 2014;13:348.
25.
go back to reference Noblit G, Hare R. Meta-ethnography: synthesizing qualitative studies. Newbury Park: Sage; 1988.CrossRef Noblit G, Hare R. Meta-ethnography: synthesizing qualitative studies. Newbury Park: Sage; 1988.CrossRef
26.
go back to reference Dixon-Woods M, Cavers D, Agarwal S, Annandale E, Arthur A, Harvey J, Hsu R, Katbamna S, Olsen R, Smith L, et al. Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups. BMC Med Res Methodol. 2006;6:35.CrossRefPubMedPubMedCentral Dixon-Woods M, Cavers D, Agarwal S, Annandale E, Arthur A, Harvey J, Hsu R, Katbamna S, Olsen R, Smith L, et al. Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups. BMC Med Res Methodol. 2006;6:35.CrossRefPubMedPubMedCentral
27.
go back to reference Schunemann HJ, Wiercioch W, Etxeandia I, Falavigna M, Santesso N, Mustafa R, Ventresca M, Brignardello-Petersen R, Laisaar KT, Kowalski S, et al. Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ. 2014;186(3):E123–142.CrossRefPubMedPubMedCentral Schunemann HJ, Wiercioch W, Etxeandia I, Falavigna M, Santesso N, Mustafa R, Ventresca M, Brignardello-Petersen R, Laisaar KT, Kowalski S, et al. Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ. 2014;186(3):E123–142.CrossRefPubMedPubMedCentral
28.
go back to reference Booth A, Harris J, Croot E, Springett J, Campbell F, Wilkins E. Towards a methodology for cluster searching to provide conceptual and contextual "richness" for systematic reviews of complex interventions: case study (CLUSTER). BMC Med Res Methodol. 2013;13:118.CrossRefPubMedPubMedCentral Booth A, Harris J, Croot E, Springett J, Campbell F, Wilkins E. Towards a methodology for cluster searching to provide conceptual and contextual "richness" for systematic reviews of complex interventions: case study (CLUSTER). BMC Med Res Methodol. 2013;13:118.CrossRefPubMedPubMedCentral
29.
go back to reference Bodeker GBG. Traditional, Complementary and Alternative Medicine: Policy and Public health Perspectives. UK: Oxford University; 2007. Bodeker GBG. Traditional, Complementary and Alternative Medicine: Policy and Public health Perspectives. UK: Oxford University; 2007.
30.
go back to reference Paterson C, Baarts C, Launso L, Verhoef MJ. Evaluating complex health interventions: a critical analysis of the 'outcomes' concept. BMC Complement Altern Med. 2009;9:18.CrossRefPubMedPubMedCentral Paterson C, Baarts C, Launso L, Verhoef MJ. Evaluating complex health interventions: a critical analysis of the 'outcomes' concept. BMC Complement Altern Med. 2009;9:18.CrossRefPubMedPubMedCentral
31.
go back to reference Coulter ID, Willis EM. The rise and rise of complementary and alternative medicine: a sociological perspective. Med J Aust. 2004;180(11):587–9.PubMed Coulter ID, Willis EM. The rise and rise of complementary and alternative medicine: a sociological perspective. Med J Aust. 2004;180(11):587–9.PubMed
32.
go back to reference Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383–94.CrossRefPubMed Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383–94.CrossRefPubMed
33.
go back to reference Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401–6.CrossRefPubMed Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401–6.CrossRefPubMed
34.
go back to reference Brunetti M, Shemilt I, Pregno S, Vale L, Oxman AD, Lord J, Sisk J, Ruiz F, Hill S, Guyatt GH, et al. GRADE guidelines: 10. Considering resource use and rating the quality of economic evidence. J Clin Epidemiol. 2013;66(2):140–50.CrossRefPubMed Brunetti M, Shemilt I, Pregno S, Vale L, Oxman AD, Lord J, Sisk J, Ruiz F, Hill S, Guyatt GH, et al. GRADE guidelines: 10. Considering resource use and rating the quality of economic evidence. J Clin Epidemiol. 2013;66(2):140–50.CrossRefPubMed
35.
go back to reference GRADE Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. In: Schünemann H, Brożek J, Guyatt G, Oxman A, editors. 2013. GRADE Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. In: Schünemann H, Brożek J, Guyatt G, Oxman A, editors. 2013.
36.
go back to reference Guyatt GH, Oxman AD, Kunz R, Atkins D, Brozek J, Vist G, Alderson P, Glasziou P, Falck-Ytter Y, Schunemann HJ. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol. 2011;64(4):395–400.CrossRefPubMed Guyatt GH, Oxman AD, Kunz R, Atkins D, Brozek J, Vist G, Alderson P, Glasziou P, Falck-Ytter Y, Schunemann HJ. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol. 2011;64(4):395–400.CrossRefPubMed
37.
go back to reference Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, et al. GRADE guidelines: 8. Rating the quality of evidence--indirectness. J Clin Epidemiol. 2011;64(12):1303–10.CrossRefPubMed Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, et al. GRADE guidelines: 8. Rating the quality of evidence--indirectness. J Clin Epidemiol. 2011;64(12):1303–10.CrossRefPubMed
38.
go back to reference Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, et al. GRADE guidelines: 7. Rating the quality of evidence--inconsistency. J Clin Epidemiol. 2011;64(12):1294–302.CrossRefPubMed Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, et al. GRADE guidelines: 7. Rating the quality of evidence--inconsistency. J Clin Epidemiol. 2011;64(12):1294–302.CrossRefPubMed
39.
go back to reference Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, Alonso-Coello P, Djulbegovic B, Atkins D, Falck-Ytter Y, et al. GRADE guidelines: 5. Rating the quality of evidence--publication bias. J Clin Epidemiol. 2011;64(12):1277–82.CrossRefPubMed Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, Alonso-Coello P, Djulbegovic B, Atkins D, Falck-Ytter Y, et al. GRADE guidelines: 5. Rating the quality of evidence--publication bias. J Clin Epidemiol. 2011;64(12):1277–82.CrossRefPubMed
40.
go back to reference Guyatt GH, Oxman AD, Santesso N, Helfand M, Vist G, Kunz R, Brozek J, Norris S, Meerpohl J, Djulbegovic B, et al. GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes. J Clin Epidemiol. 2013;66(2):158–72.CrossRefPubMed Guyatt GH, Oxman AD, Santesso N, Helfand M, Vist G, Kunz R, Brozek J, Norris S, Meerpohl J, Djulbegovic B, et al. GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes. J Clin Epidemiol. 2013;66(2):158–72.CrossRefPubMed
41.
go back to reference Guyatt GH, Oxman AD, Schunemann HJ. GRADE guidelines-an introduction to the 10th-13th articles in the series. J Clin Epidemiol. 2013;66(2):121–3.CrossRefPubMed Guyatt GH, Oxman AD, Schunemann HJ. GRADE guidelines-an introduction to the 10th-13th articles in the series. J Clin Epidemiol. 2013;66(2):121–3.CrossRefPubMed
42.
go back to reference Guyatt GH, Oxman AD, Sultan S, Glasziou P, Akl EA, Alonso-Coello P, Atkins D, Kunz R, Brozek J, Montori V, et al. GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol. 2011;64(12):1311–6.CrossRefPubMed Guyatt GH, Oxman AD, Sultan S, Glasziou P, Akl EA, Alonso-Coello P, Atkins D, Kunz R, Brozek J, Montori V, et al. GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol. 2011;64(12):1311–6.CrossRefPubMed
43.
go back to reference Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, et al. GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). J Clin Epidemiol. 2011;64(4):407–15.CrossRefPubMed Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, et al. GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). J Clin Epidemiol. 2011;64(4):407–15.CrossRefPubMed
44.
go back to reference Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, Johnston BC, Karanicolas P, Akl EA, Vist G, et al. GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes. J Clin Epidemiol. 2013;66(2):173–83.CrossRefPubMed Guyatt GH, Thorlund K, Oxman AD, Walter SD, Patrick D, Furukawa TA, Johnston BC, Karanicolas P, Akl EA, Vist G, et al. GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes. J Clin Epidemiol. 2013;66(2):173–83.CrossRefPubMed
46.
47.
go back to reference Fretheim A, Munabi-Babigumira S, Oxman AD, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 6: Using research evidence to address how an option will be implemented. Health Res Policy Syst. 2009;7 Suppl 1:S6.CrossRefPubMed Fretheim A, Munabi-Babigumira S, Oxman AD, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 6: Using research evidence to address how an option will be implemented. Health Res Policy Syst. 2009;7 Suppl 1:S6.CrossRefPubMed
48.
go back to reference Fretheim A, Oxman AD, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 18: Planning monitoring and evaluation of policies. Health Res Policy Syst/BioMed Centra. 2009;7 Suppl 1:S18.CrossRef Fretheim A, Oxman AD, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 18: Planning monitoring and evaluation of policies. Health Res Policy Syst/BioMed Centra. 2009;7 Suppl 1:S18.CrossRef
49.
go back to reference Lavis JN, Boyko JA, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 14: Organising and using policy dialogues to support evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S14.CrossRefPubMed Lavis JN, Boyko JA, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 14: Organising and using policy dialogues to support evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S14.CrossRefPubMed
50.
go back to reference Lavis JN, Oxman AD, Grimshaw J, Johansen M, Boyko JA, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 7: Finding systematic reviews. Health Res Policy Syst. 2009;7 Suppl 1:S7.CrossRefPubMed Lavis JN, Oxman AD, Grimshaw J, Johansen M, Boyko JA, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 7: Finding systematic reviews. Health Res Policy Syst. 2009;7 Suppl 1:S7.CrossRefPubMed
51.
go back to reference Lavis JN, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 3: Setting priorities for supporting evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S3.CrossRefPubMed Lavis JN, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 3: Setting priorities for supporting evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S3.CrossRefPubMed
52.
go back to reference Lavis JN, Oxman AD, Souza NM, Lewin S, Gruen RL, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 9: Assessing the applicability of the findings of a systematic review. Health Res Policy Syst. 2009;7 Suppl 1:S9.CrossRefPubMed Lavis JN, Oxman AD, Souza NM, Lewin S, Gruen RL, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 9: Assessing the applicability of the findings of a systematic review. Health Res Policy Syst. 2009;7 Suppl 1:S9.CrossRefPubMed
53.
go back to reference Lavis JN, Permanand G, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 13: Preparing and using policy briefs to support evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S13.CrossRefPubMed Lavis JN, Permanand G, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 13: Preparing and using policy briefs to support evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S13.CrossRefPubMed
54.
go back to reference Lavis JN, Wilson MG, Oxman AD, Grimshaw J, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 5: Using research evidence to frame options to address a problem. Health Res Policy Syst. 2009;7 Suppl 1:S5.CrossRefPubMed Lavis JN, Wilson MG, Oxman AD, Grimshaw J, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 5: Using research evidence to frame options to address a problem. Health Res Policy Syst. 2009;7 Suppl 1:S5.CrossRefPubMed
55.
go back to reference Lavis JN, Wilson MG, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 4: Using research evidence to clarify a problem. Health Res Policy Syst. 2009;7 Suppl 1:S4.CrossRefPubMed Lavis JN, Wilson MG, Oxman AD, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 4: Using research evidence to clarify a problem. Health Res Policy Syst. 2009;7 Suppl 1:S4.CrossRefPubMed
56.
go back to reference Lewin S, Oxman AD, Lavis JN, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 8: Deciding how much confidence to place in a systematic review. Health Res Policy Syst. 2009;7 Suppl 1:S8.CrossRefPubMed Lewin S, Oxman AD, Lavis JN, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 8: Deciding how much confidence to place in a systematic review. Health Res Policy Syst. 2009;7 Suppl 1:S8.CrossRefPubMed
57.
go back to reference Lewin S, Oxman AD, Lavis JN, Fretheim A, Garcia Marti S, Munabi-Babigumira S. SUPPORT Tools for evidence-informed health Policymaking (STP) 11: Finding and using evidence about local conditions. Health Res Policy Syst. 2009;7 Suppl 1:S11.CrossRefPubMed Lewin S, Oxman AD, Lavis JN, Fretheim A, Garcia Marti S, Munabi-Babigumira S. SUPPORT Tools for evidence-informed health Policymaking (STP) 11: Finding and using evidence about local conditions. Health Res Policy Syst. 2009;7 Suppl 1:S11.CrossRefPubMed
58.
go back to reference Oxman AD, Fretheim A, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 12: Finding and using research evidence about resource use and costs. Health Res Policy Syst. 2009;7 Suppl 1:S12.CrossRefPubMed Oxman AD, Fretheim A, Lavis JN, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 12: Finding and using research evidence about resource use and costs. Health Res Policy Syst. 2009;7 Suppl 1:S12.CrossRefPubMed
59.
go back to reference Oxman AD, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 16: Using research evidence in balancing the pros and cons of policies. Health Res Policy Syst. 2009;7 Suppl 1:S16.CrossRefPubMed Oxman AD, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 16: Using research evidence in balancing the pros and cons of policies. Health Res Policy Syst. 2009;7 Suppl 1:S16.CrossRefPubMed
60.
go back to reference Oxman AD, Lavis JN, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 10: Taking equity into consideration when assessing the findings of a systematic revie. Health Res Policy Syst. 2009;7 Suppl 1:S10.CrossRefPubMed Oxman AD, Lavis JN, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 10: Taking equity into consideration when assessing the findings of a systematic revie. Health Res Policy Syst. 2009;7 Suppl 1:S10.CrossRefPubMed
61.
go back to reference Oxman AD, Lavis JN, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 1: What is evidence-informed policymaking? Health Res Policy Syst. 2009;7 Suppl 1:S1.CrossRefPubMed Oxman AD, Lavis JN, Lewin S, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 1: What is evidence-informed policymaking? Health Res Policy Syst. 2009;7 Suppl 1:S1.CrossRefPubMed
62.
go back to reference Oxman AD, Lewin S, Lavis JN, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 15: Engaging the public in evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S15.CrossRefPubMed Oxman AD, Lewin S, Lavis JN, Fretheim A. SUPPORT Tools for evidence-informed health Policymaking (STP) 15: Engaging the public in evidence-informed policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S15.CrossRefPubMed
63.
go back to reference Oxman AD, Vandvik PO, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 2: Improving how your organisation supports the use of research evidence to inform policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S2.CrossRefPubMed Oxman AD, Vandvik PO, Lavis JN, Fretheim A, Lewin S. SUPPORT Tools for evidence-informed health Policymaking (STP) 2: Improving how your organisation supports the use of research evidence to inform policymaking. Health Res Policy Syst. 2009;7 Suppl 1:S2.CrossRefPubMed
64.
go back to reference NHMRC. A guide to the development, evaluation and implementation of clinical practice guidelines. National Health & Medical Research Council. Canberra: Commonwealth of Australia; 1999. NHMRC. A guide to the development, evaluation and implementation of clinical practice guidelines. National Health & Medical Research Council. Canberra: Commonwealth of Australia; 1999.
65.
go back to reference Hillier S, Grimmer-Somers K, Merlin T, Middleton P, Salisbury J, Tooher R, Weston A. FORM: an Australian method for formulating and grading recommendations in evidence-based clinical guidelines. BMC Med Res Methodol. 2011;11:23.CrossRefPubMedPubMedCentral Hillier S, Grimmer-Somers K, Merlin T, Middleton P, Salisbury J, Tooher R, Weston A. FORM: an Australian method for formulating and grading recommendations in evidence-based clinical guidelines. BMC Med Res Methodol. 2011;11:23.CrossRefPubMedPubMedCentral
66.
go back to reference Merlin T, Weston A, Tooher R, Middleton P, Salisbury J, Coleman K, Norris S, Grimmer-Somers K, Hillier S. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines. Australia: National Health and Medical Research Council; 2009. Merlin T, Weston A, Tooher R, Middleton P, Salisbury J, Coleman K, Norris S, Grimmer-Somers K, Hillier S. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines. Australia: National Health and Medical Research Council; 2009.
68.
go back to reference SIGN. SIGN 50 - A guideline developer's handbook. Edinburgh: Scottish Intercollegiate Guidelines Network (SIGN); 2014. SIGN. SIGN 50 - A guideline developer's handbook. Edinburgh: Scottish Intercollegiate Guidelines Network (SIGN); 2014.
69.
go back to reference USPSTF: U.S. Preventive Services Task Force Procedure Manual. AHRQ Publication No. 08-05118-EF edn. 2008 USPSTF: U.S. Preventive Services Task Force Procedure Manual. AHRQ Publication No. 08-05118-EF edn. 2008
71.
go back to reference Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM, Atkins D. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001;20(3 Suppl):21–35.CrossRefPubMed Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM, Atkins D. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001;20(3 Suppl):21–35.CrossRefPubMed
72.
go back to reference NICE. Developing NICE guidelines: the manual. Process and methods guide. London: National Institute for Health and Care Excellence; 2014. NICE. Developing NICE guidelines: the manual. Process and methods guide. London: National Institute for Health and Care Excellence; 2014.
73.
go back to reference NICE. The guidelines manual. Process and methods guide. London: National Institute for Health and Care Excellence; 2012. NICE. The guidelines manual. Process and methods guide. London: National Institute for Health and Care Excellence; 2012.
74.
go back to reference Thornton J, Alderson P, Tan T, Turner C, Latchem S, Shaw E, Ruiz F, Reken S, Mugglestone MA, Hill J, et al. Introducing GRADE across the NICE clinical guideline program. J Clin Epidemiol. 2013;66(2):124–31.CrossRefPubMed Thornton J, Alderson P, Tan T, Turner C, Latchem S, Shaw E, Ruiz F, Reken S, Mugglestone MA, Hill J, et al. Introducing GRADE across the NICE clinical guideline program. J Clin Epidemiol. 2013;66(2):124–31.CrossRefPubMed
75.
go back to reference Boon H, Macpherson H, Fleishman S, Grimsgaard S, Koithan M, Norheim AJ, Walach H. Evaluating Complex Healthcare Systems: A Critique of Four Approaches. Evid Based Complement Alternat Med. 2007;4(3):279–85.CrossRefPubMed Boon H, Macpherson H, Fleishman S, Grimsgaard S, Koithan M, Norheim AJ, Walach H. Evaluating Complex Healthcare Systems: A Critique of Four Approaches. Evid Based Complement Alternat Med. 2007;4(3):279–85.CrossRefPubMed
76.
go back to reference Deng G, Weber W, Sood A, Kemper KJ. Research on integrative healthcare: context and priorities. Explore (NY). 2010;6(3):143–58.CrossRef Deng G, Weber W, Sood A, Kemper KJ. Research on integrative healthcare: context and priorities. Explore (NY). 2010;6(3):143–58.CrossRef
77.
go back to reference Hunter J, Corcoran K, Leeder S, Phelps K. Integrative medicine outcomes: What should we measure? Complement Ther Clin Pract. 2013;19(1):20–6.CrossRefPubMed Hunter J, Corcoran K, Leeder S, Phelps K. Integrative medicine outcomes: What should we measure? Complement Ther Clin Pract. 2013;19(1):20–6.CrossRefPubMed
78.
79.
go back to reference Smith Caroline A, Hay Phillipa PJ, MacPherson H. Acupuncture for depression. In: Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd; 2010. Smith Caroline A, Hay Phillipa PJ, MacPherson H. Acupuncture for depression. In: Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd; 2010.
80.
go back to reference Costanzo S, di Niro V, Di Castelnuovo A, Gianfagna F, Donati MB, de Gaetano G, Iacoviello L. Prevention of postoperative atrial fibrillation in open heart surgery patients by preoperative supplementation of n-3 polyunsaturated fatty acids: an updated meta-analysis. J Thorac Cardiovasc Surg. 2013;146(4):906–11.CrossRefPubMed Costanzo S, di Niro V, Di Castelnuovo A, Gianfagna F, Donati MB, de Gaetano G, Iacoviello L. Prevention of postoperative atrial fibrillation in open heart surgery patients by preoperative supplementation of n-3 polyunsaturated fatty acids: an updated meta-analysis. J Thorac Cardiovasc Surg. 2013;146(4):906–11.CrossRefPubMed
81.
go back to reference Xin W, Wei W, Lin Z, Zhang X, Yang H, Zhang T, Li B, Mi S. Fish oil and atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials. PLoS One. 2013;8(9):e72913.CrossRefPubMedPubMedCentral Xin W, Wei W, Lin Z, Zhang X, Yang H, Zhang T, Li B, Mi S. Fish oil and atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials. PLoS One. 2013;8(9):e72913.CrossRefPubMedPubMedCentral
84.
go back to reference Maclennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004;4:CD002978. Maclennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004;4:CD002978.
85.
go back to reference Rossouw JE, Manson JE, Kaunitz AM, Anderson GL. Lessons learned from the Women's Health Initiative trials of menopausal hormone therapy. Obstet Gynecol. 2013;121(1):172–6.CrossRefPubMedPubMedCentral Rossouw JE, Manson JE, Kaunitz AM, Anderson GL. Lessons learned from the Women's Health Initiative trials of menopausal hormone therapy. Obstet Gynecol. 2013;121(1):172–6.CrossRefPubMedPubMedCentral
86.
go back to reference Beer AM, Osmers R, Schnitker J, Bai W, Mueck AO, Meden H. Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review). Gynecol Endocrinol. 2013;29(12):1022–5.CrossRefPubMed Beer AM, Osmers R, Schnitker J, Bai W, Mueck AO, Meden H. Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review). Gynecol Endocrinol. 2013;29(12):1022–5.CrossRefPubMed
87.
go back to reference Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev. 2012;9:CD007244. Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev. 2012;9:CD007244.
88.
go back to reference Peng W, Adams J, Sibbritt DW, Frawley JE. Critical review of complementary and alternative medicine use in menopause: focus on prevalence, motivation, decision-making, and communication. Menopause. 2014;21(5):536–48.CrossRefPubMed Peng W, Adams J, Sibbritt DW, Frawley JE. Critical review of complementary and alternative medicine use in menopause: focus on prevalence, motivation, decision-making, and communication. Menopause. 2014;21(5):536–48.CrossRefPubMed
89.
go back to reference Posadzki P, Lee MS, Moon TW, Choi TY, Park TY, Ernst E. Prevalence of complementary and alternative medicine (CAM) use by menopausal women: a systematic review of surveys. Maturitas. 2013;75(1):34–43.CrossRefPubMed Posadzki P, Lee MS, Moon TW, Choi TY, Park TY, Ernst E. Prevalence of complementary and alternative medicine (CAM) use by menopausal women: a systematic review of surveys. Maturitas. 2013;75(1):34–43.CrossRefPubMed
90.
go back to reference Gentry-Maharaj A, Karpinskyj C, Glazer C, Burnell M, Ryan A, Fraser L, Lanceley A, Jacobs I, Hunter MS, Menon U. Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study. Menopause. 2015;22(4):384–90.CrossRefPubMedPubMedCentral Gentry-Maharaj A, Karpinskyj C, Glazer C, Burnell M, Ryan A, Fraser L, Lanceley A, Jacobs I, Hunter MS, Menon U. Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study. Menopause. 2015;22(4):384–90.CrossRefPubMedPubMedCentral
91.
go back to reference Gores KM, Hamieh TS, Schmidt GA. Survival following investigational treatment of amanita mushroom poisoning: thistle or shamrock? Chest. 2014;146(4):e126–129.CrossRefPubMed Gores KM, Hamieh TS, Schmidt GA. Survival following investigational treatment of amanita mushroom poisoning: thistle or shamrock? Chest. 2014;146(4):e126–129.CrossRefPubMed
92.
go back to reference Mengs U, Pohl RT, Mitchell T. Legalon(R) SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012;13(10):1964–70.CrossRefPubMedPubMedCentral Mengs U, Pohl RT, Mitchell T. Legalon(R) SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012;13(10):1964–70.CrossRefPubMedPubMedCentral
94.
go back to reference Fowler 3rd AA, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12:32.CrossRefPubMedPubMedCentral Fowler 3rd AA, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12:32.CrossRefPubMedPubMedCentral
95.
go back to reference Jacobs C, Hutton B, Ng T, Shorr R, Clemons M. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist. 2015;20(2):210–23.CrossRefPubMedPubMedCentral Jacobs C, Hutton B, Ng T, Shorr R, Clemons M. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist. 2015;20(2):210–23.CrossRefPubMedPubMedCentral
96.
go back to reference Kongtharvonskul J, Anothaisintawee T, McEvoy M, Attia J, Woratanarat P, Thakkinstian A. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis. Eur J Med Res. 2015;20:24.CrossRefPubMedPubMedCentral Kongtharvonskul J, Anothaisintawee T, McEvoy M, Attia J, Woratanarat P, Thakkinstian A. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis. Eur J Med Res. 2015;20:24.CrossRefPubMedPubMedCentral
97.
go back to reference Bruyere O, Cooper C, Pelletier JP, Branco J, Luisa Brandi M, Guillemin F, Hochberg MC, Kanis JA, Kvien TK, Martel-Pelletier J, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014;44(3):253–63.CrossRefPubMed Bruyere O, Cooper C, Pelletier JP, Branco J, Luisa Brandi M, Guillemin F, Hochberg MC, Kanis JA, Kvien TK, Martel-Pelletier J, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014;44(3):253–63.CrossRefPubMed
98.
go back to reference Linde K, Berner MM, Kriston L. St John's wort for major depression. Cochrane Database Syst Rev. 2008;4:CD000448. Linde K, Berner MM, Kriston L. St John's wort for major depression. Cochrane Database Syst Rev. 2008;4:CD000448.
99.
go back to reference Raja M, Azzoni A. Hypericum-induced mood disorder: switch from depression to mixed episodes in two patients. Int J Psychiatry Clin Pract. 2006;10(2):146–8.CrossRefPubMed Raja M, Azzoni A. Hypericum-induced mood disorder: switch from depression to mixed episodes in two patients. Int J Psychiatry Clin Pract. 2006;10(2):146–8.CrossRefPubMed
100.
go back to reference Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review. BMJ. 2005;330(7488):385.CrossRefPubMedPubMedCentral Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review. BMJ. 2005;330(7488):385.CrossRefPubMedPubMedCentral
Metadata
Title
An interpretive review of consensus statements on clinical guideline development and their application in the field of traditional and complementary medicine
Authors
Jennifer Hunter
Matthew Leach
Lesley Braun
Alan Bensoussan
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-017-1613-7

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