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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2016 | Research article

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

Authors: Vikas Kumar, Prakash Chandra Bhatt, Kalicharan Sharma, Mahfoozur Rahman, Dinesh Kumar Patel, Nikunj Sethi, Atul Kumar, Nikhil Kumar Sachan, Gaurav Kaithwas, F. A. Al-abbasi, Firoz Anwar, Amita Verma

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

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Abstract

Background

Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as “putki,” has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats.

Methods

High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.

Result & discussion

Current study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P < 0.001) modulated the oxidative stress parameters as well as hematological parameter induced by CFA. The result also altered the distorted level of proinflammatory mediators and inflammatory mediator, which further reinforce the implication of MM in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the MM treated group which provides evidence for the antiarthritic effect of MM.

Conclusion

From above parameters our study states that the MM is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of MM could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect.

Graphical abstract

Figure Caption: Melastoma Malabathricum Linn Attenuates Complete Freund’s Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response
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Metadata
Title
RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response
Authors
Vikas Kumar
Prakash Chandra Bhatt
Kalicharan Sharma
Mahfoozur Rahman
Dinesh Kumar Patel
Nikunj Sethi
Atul Kumar
Nikhil Kumar Sachan
Gaurav Kaithwas
F. A. Al-abbasi
Firoz Anwar
Amita Verma
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1470-9

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