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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2016 | Research article

RETRACTED ARTICLE: Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis

Authors: Yong-Deok Jeon, Keuk-Soo Bang, Min-Kyoung Shin, Jong-Hyun Lee, Young-Nam Chang, Jong-Sik Jin

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

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Abstract

Background

Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely-used in clinical health care. The clinical functions of GR include relief of toxicity, anti-cancer, regulating blood cholesterol and anti-inflammation. This study investigated the role of GR on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse model of colitis.

Method

Western blot analysis and enzyme-linked immunosorbent assay (ELISA) analyses were done on male BALB/c mice administered 5 % DSS during the experimental period. Ethanol extracts of GR were orally administered at same time daily to control mice. The severity of colitis was measured by body weight change and colon length.

Result

DSS-treated mice displayed weight loss and shortened colon length compared with control mice. Mice were administered GR showed less weight loss and longer colon length than the DSS-treated group. Inflammatory cytokines were decreased by GR treatment. Treatment also reduced DSS-induced microscopic damage to colon tissue. GR regulated the phosphorylation of transcription factors such as NF-κB p65 and IκB α.

Conclusions

GR has beneficial effects in a colitis model. GR might be a useful herb medicine in the treatment of ulcerative colitis.
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Metadata
Title
RETRACTED ARTICLE: Regulatory effects of glycyrrhizae radix extract on DSS-induced ulcerative colitis
Authors
Yong-Deok Jeon
Keuk-Soo Bang
Min-Kyoung Shin
Jong-Hyun Lee
Young-Nam Chang
Jong-Sik Jin
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1390-8

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