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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2016 | Research article

Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species

Authors: Amabel Fernandes Correia, Dâmaris Silveira, Yris Maria Fonseca-Bazzo, Pérola Oliveira Magalhães, Christopher William Fagg, Elton Clementino da Silva, Suelí Maria Gomes, Lenora Gandolfi, Riccardo Pratesi, Yanna Karla de Medeiros Nóbrega

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

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Abstract

Background

Medicinal plants have traditionally been used in many parts of the world as alternative medicine. Many extracts and essential oils isolated from plants have disclosed biological activity, justifying the investigation of their potential antimicrobial activity. In this study, the in vitro antifungal activity of six Brazilian Cerrado medicinal plant species were evaluated against clinically relevant Candida species.

Methods

The crude extract plants were evaluated against American Type Culture Collection (ATCC) standard strains of Candida spp. using disk diffusion method and determining the minimum inhibitory concentration (MIC). The chemical study results were confirmed by HPLC method.

Results

All six plant species showed antifungal activity. Among the species studied, Eugenia dysenterica and Pouteria ramiflora showed significant inhibitory activity against C. tropicalis at lowest MIC value of 125 and 500 μg/disc, respectively. The Eugenia dysenterica also disclosed MIC value of 125 μg/disc against C. famata, 250 μg/disc against C. krusei and 500 μg/disc against C. guilliermondii and C. parapsilosis. Pouteria torta, Bauhinia rufa, Erythroxylum daphnites and Erythroxylum subrotundum showed activity against the yeast strains with MIC value of 1000 μg/disc. The chemical study of the most bioactive extracts of Eugenia dysenterica and Pouteria ramiflora revealed catechin derivatives and flavonoids as main components.

Conclusions

All six evaluated plant species showed good antifungal potential against several Candida strains. However, E .dysenterica and P. ramiflora showed the higher inhibitory effect against the non-albicans Candida species. Our results may contribute to the continuing search of new natural occurring products with antifungal activity.
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Metadata
Title
Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species
Authors
Amabel Fernandes Correia
Dâmaris Silveira
Yris Maria Fonseca-Bazzo
Pérola Oliveira Magalhães
Christopher William Fagg
Elton Clementino da Silva
Suelí Maria Gomes
Lenora Gandolfi
Riccardo Pratesi
Yanna Karla de Medeiros Nóbrega
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1164-3

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