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BMC Women's Health
Published in: BMC Women's Health 1/2019

Open Access 01-12-2019 | Magnetic Resonance Imaging | Research article

Analysis of uterine corporeal mesenchymal tumors occurring after menopause

Authors: Yumi Ishidera, Hiroshi Yoshida, Yuka Oi, Kayo Katayama, Etsuko Miyagi, Hiroyuki Hayashi, Hiroyuki Shigeta

Published in: BMC Women's Health | Issue 1/2019

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Abstract

Objective

Because it is difficult to diagnose accurately whether uterine corporeal mesenchymal tumors are benign or malignant before surgery, an understanding of the characteristics of patients with uterine sarcomas occurring in the postmenopausal period is required.

Methods

We retrospectively reviewed the cases of women who underwent surgery for uterine mesenchymal tumors at our hospital.

Results

Among 487 operated cases, 447 tumors occurred in the premenopausal period and 40 occurred in the postmenopausal period. Uterine sarcomas were observed in 5 cases (1.1%) during the premenopausal period and in 11 cases (28%) during the postmenopausal period. Among the postmenopausal patients, age, age at menopause, body mass index (BMI), tumor size, incidence of abnormal vaginal bleeding, serum tumor marker levels (cancer antigen 125, carbohydrate antigen 19–9, and carcinoembryonic antigen), and serum lactate dehydrogenase values were not significantly different between patients with benign tumors and those with malignant tumors. On the other hand, the incidence to have abnormal signal on MRI was significantly higher in patients with malignant tumors than in patients with benign tumors.

Conclusion

In our hospital, the incidence of malignant tumors in women with uterine corporeal mesenchymal tumors was much higher in postmenopausal patients than in premenopausal patients. Because it is generally not easy to diagnose uterine sarcomas before surgery, surgery should be positively considered when uterine sarcomas cannot be ruled out for patients in the postmenopausal period.
Literature
1.
Templeman C, Marshall SF, Clarke CA, et al. Risk factors for surgically removed fibroids in a large cohort of teachers. Fertil Steril. 2009;92:1436–46.CrossRef
2.
Klimentova DV, Braila AD, Simionescu C, Ilie I, Braila MB. Clinical and paraclinical study regarding the macro- and microscopic diagnosis of various anatomo-clinical forms of operated uterine fibromyoma. Romanian J Morphol Embryol. 2012;53:369–73.
3.
Mao J, Pfeifer S, Zheng XE, Schlegel P, Sedrakyan A. Population-based estimates of the prevalence of uterine sarcoma among patients with leiomyomata undergoing surgical treatment. JAMA Surg. 2015;150:368–70.CrossRef
4.
Yilmaz N, Sahin I, Kilic S, Ozgu E, Gungor T, Bilge U. Assessment of the predictivity of preoperative serum CA 125 in the differential diagnosis of uterine leiomyoma and uterine sarcoma in the Turkish female population. Eur J Gynaecol Oncol. 2009;30:412–4.PubMed
5.
Oliva E, Loening T, Carcangiu ML, Longacre TA, Carinelli SG, Nucci MR, et al. Mesenchymal tumors. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. WHO classification of Tumours of female reproductive organs. Fourth Edition. Lyon: International Agency for Research on Cancer; 2014. p. 135–147.
6.
Trope CG, Abeler VM, Kristensen GB. Diagnosis and treatment of sarcoma of the uterus. A review. Acta Oncol. 2012;51:694–705.CrossRef
7.
Wu T-I, Yen T-C, Lay C-H. Clinical presentation and diagnosis of uterine sarcoma, including imaging. Best Pract Res Clin Obstet Gynaecol. 2011;25:681–9.CrossRef
8.
Buttram V, Reiter R. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36:433–45.CrossRef
9.
Christopherson W, Williamson E, Gray L. Leiomyosarcoma of the uterus. Cancer. 1972;29:1512–7.CrossRef
10.
Brohl AS, Li L, Andikyan V, Obican SG, Cioffi A, Hao K, et al. Age-specific risk of unexpected uterine sarcoma following surgery for presumed benign leiomyoma. Oncologist. 2015;20:433–9.CrossRef
11.
Nagai T, Takai Y, Akahori T, Ishida H, Hanaoka T, Uotani T, et al. Novel uterine sarcoma preoperative diagnosis score predicts the need for surgery in patients presenting with a uterine mass. Springerplus. 2014;3:678.CrossRef
12.
Sagae S, Yamashita K, Ishioka S, Nishioka Y, Terasawa K, Mori M, et al. Preoperative diagnosis and treatment results in 106 patients with uterine sarcoma in Hokkaido, Japan. Oncology. 2004;67:33–9.CrossRef
13.
Parker WH, Fu YS, Berek JS. Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol. 1994;83:414–8.PubMed
14.
Juang CM, Yen MS, Horng HC, Twu NF, Yu HC, Hsu WL. Potential role of preoperative serum CA125 for the differential diagnosis between uterine leiomyoma and uterine leiomyosarcoma. Eur J Gynaecol Oncol. 2006;27:370–4.PubMed
15.
Duk JM, Bouma J, Burger GT, Nap M, De Bruijn HW. CA125 in serum and tumor from patients with uterine sarcoma. Int J Gynecol Cancer 1994; 4: 156–160.
16.
Sahdev A, Sohaib SA, Jacobs I, Shepherd JH, Oram DH, Reznek RH. MR imaging of uterine sarcomas. Am J Roentgenol. 2001;177:1307–11.CrossRef
17.
Kido A, Togashi K, Koyama T, Yamaoka T, Fujiwara T, Fujii S. Diffusely enlarged uterus: evaluation with MR imaging. Radiographics. 2003;23:1423–39.CrossRef
18.
Tanaka YO, Nishida M, Tsunoda H, Okamoto Y, Yoshikawa H. Smooth muscle tumors of uncertain malignant potential and leiomyosarcomas of the uterus: MR findings. J Magn Reson Imaging. 2004;20:998–1007.CrossRef
19.
Yoshida Y, Kurokawa T, Sawamura Y, Shinagawa A, Tsujikawa T, Okazawa H, et al. Comparison of 18F-FDG PET and MRI in assessment of uterine smooth muscle tumors. J Nucl Med. 2008;49:708–12.CrossRef
20.
Kitajima K, Murakami K, Kaji Y, Sugimura K. Spectrum of FDG PET/CT findings of uterine tumors. Am J Roentgenol. 2010;195:737–43.CrossRef
21.
Yoshida Y, Kiyono Y, Tsujikawa T, Kurokawa T, Okazawa H, Kotsuji F. Additional value of 16α-[18F]-fluoro-17β-oestradiol PET for differential diagnosis between uterine sarcoma and leiomyoma in patients with positive or equivocal findings on [18F]fluorodeoxyglucose PET. Eur J Nucl Med Mol Imaging. 2011;38:1824–31.CrossRef
22.
Kawamura N, Ichimura T, Ito F, Shibata S, Takahashi K, Tsujimura A, et al. Transcervical needle biopsy for the differential diagnosis between uterine sarcoma and leiomyoma. Cancer. 2002;94:1713–20.CrossRef
Metadata
Title
Analysis of uterine corporeal mesenchymal tumors occurring after menopause
Authors
Yumi Ishidera
Hiroshi Yoshida
Yuka Oi
Kayo Katayama
Etsuko Miyagi
Hiroyuki Hayashi
Hiroyuki Shigeta
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2019
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-019-0714-5

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