Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Oral Health
Published in: BMC Oral Health 1/2017

Open Access 01-12-2017 | Research article

The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children

Authors: Yuan-yuan Kong, Jian-mao Zheng, Wen-juan Zhang, Qian-zhou Jiang, Xue-chao Yang, Miao Yu, Su-juan Zeng

Published in: BMC Oral Health | Issue 1/2017

Login to get access

Abstract

Background

In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children.

Methods

Our study included 380 Chinese children aged 4–7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP.

Results

The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1.856, 95% CI = [1.184, 2.908], p = 0.007). However, VDR polymorphisms ApaI, TaqI and FokI were not associated with deciduous tooth decay (ApaI: OR = 0.839, 95% CI = [0.614, 1.145], p = 0.268; TaqI: OR = 1.150, 95% CI = [0.495, 2.672], p = 0.744; FokI: OR = 0.856, 95% CI = [0.616, 1.191], p = 0.356).

Conclusions

Our results showed that VDR BsmI polymorphism was associated with the risk of deciduous tooth decay in Chinese children aged 4–7 years. However, the specific mechanism remains to further verify through experiment.
Literature
1.
Dye BA, Hsu KL, Afful J. Prevalence and measurement of dental caries in young children. Pediatr Dent. 2015;37(3):200–16.PubMed
2.
3.
Sheiham A. Dental caries affects body weight, growth and quality of life in pre-school children. Br Dent J. 2006;201(10):625–6.CrossRefPubMed
4.
Opal S, Garg S, Jain J, Walia I. Genetic factors affecting dental caries risk. Aust Dent J. 2015;60(1):2–11.CrossRefPubMed
5.
Wang X, Shaffer JR, Weyant RJ, Cuenco KT, DeSensi RS, Crout R, McNeil DW, Marazita ML. Genes and their effects on dental caries may differ between primary and permanent dentitions. Caries Res. 2010;44(3):277–84.CrossRefPubMedPubMedCentral
6.
Shaffer JR, Wang X, Desensi RS, Wendell S, Weyant RJ, Cuenco KT, Crout R, McNeil DW, Marazita ML. Genetic susceptibility to dental caries on pit and fissure and smooth surfaces. Caries Res. 2012;46(1):38–46.CrossRefPubMedPubMedCentral
7.
Romanos HF, Antunes LS, Lopes LB, Saboia Tde M, Tannure PN, Lips A, Antunes LA, Abreu FV, Deeley K, Alves G, et al. BMP2 is associated with caries experience in primary teeth. Caries Res. 2015;49(4):425–33.CrossRefPubMed
8.
Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338(2):143–56.CrossRefPubMed
9.
Hujoel PP. Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis. Nutr Rev. 2013;71(2):88–97.CrossRefPubMed
10.
Purvis RJ, Barrie WJ, MacKay GS, Wilkinson EM, Cockburn F, Belton NR. Enamel hypoplasia of the teeth associated with neonatal tetany: a manifestation of maternal vitamin-D deficiency. Lancet. 1973;2(7833):811–4.CrossRefPubMed
11.
Hong L, Levy SM, Warren JJ, Broffitt B. Association between enamel hypoplasia and dental caries in primary second molars: a cohort study. Caries Res. 2009;43(5):345–53.CrossRefPubMedPubMedCentral
12.
Pascoe L, Seow WK. Enamel hypoplasia and dental caries in Australian aboriginal children: prevalence and correlation between the two diseases. Pediatr Dent. 1994;16(3):193–9.PubMed
13.
Clark A, Mach N. Role of vitamin D in the hygiene hypothesis: the interplay between vitamin D, vitamin D receptors, gut microbiota, and immune response. Front Immunol. 2016;7:627.CrossRefPubMedPubMedCentral
14.
15.
Sutton AL, MacDonald PN. Vitamin D: more than a “bone-a-fide” hormone. Mol Endocrinol. 2003;17(5):777–91.CrossRefPubMed
16.
Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006;371(1–2):1–12.CrossRefPubMed
17.
Antunes LA, Antunes LS, Kuchler EC, Lopes LB, Moura A, Bigonha RS, Abreu FV, Granjeiro JM, de Amorim LM, Paixao IC. Analysis of the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 genes with white spot lesions and early childhood caries. Int J Paediatr Dent. 2016;26(4):310–9.CrossRefPubMed
18.
World Health OrganizationOral health surveys: basic methods. Geneva: World Health Organization 2013.
19.
Klein H, Palmer CE, Knutson JW. Studies on dental caries: I. Dental status and dental needs of elementary school children. Public Health Rep. 1938;53(19):751.CrossRef
20.
Olszowski T, Adler G, Janiszewska-Olszowska J, Safranow K, Kaczmarczyk M. MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in polish children. Oral Dis. 2012;18(4):389–95.CrossRefPubMed
21.
Li S, Yang MH, Zeng CA, Wu WL, Huang XF, Ji Y, Zeng JQ. Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. J Periodontal Res. 2008;43(3):360–3.CrossRefPubMed
22.
Yildiz G, Ermis RB, Calapoglu NS, Celik EU, Turel GY. Gene-environment interactions in the etiology of dental caries. J Dent Res. 2016;95(1):74–9.CrossRefPubMed
23.
Shuler CF. Inherited risks for susceptibility to dental caries. J Dent Educ. 2001;65(10):1038–45.PubMed
24.
Shelling AN, Ferguson LR. Genetic variation in human disease and a new role for copy number variants. Mutat Res. 2007;622(1–2):33–41.CrossRefPubMed
25.
Klein H. The family and dental disease; size of family and dental caries (DMF) experience in offspring. Am J Orthod Oral Surg. 1946;32:533.CrossRefPubMed
26.
Bretz WA, Corby PM, Schork NJ, Robinson MT, Coelho M, Costa S, Melo Filho MR, Weyant RJ, Hart TC. Longitudinal analysis of heritability for dental caries traits. J Dent Res. 2005;84(11):1047–51.CrossRefPubMedPubMedCentral
27.
Li ZQ, Hu XP, Zhou JY, Xie XD, Zhang JM. Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility. Genet Mol Res. 2015;14(2):5986–93.CrossRefPubMed
28.
Tannure PN, Kuchler EC, Falagan-Lotsch P, Amorim LM, Raggio Luiz R, Costa MC, Vieira AR, Granjeiro JM. MMP13 polymorphism decreases risk for dental caries. Caries Res. 2012;46(4):401–7.CrossRefPubMed
29.
Stephanopoulos G, Garefalaki ME, Lyroudia K. Genes and related proteins involved in amelogenesis imperfecta. J Dent Res. 2005;84(12):1117–26.CrossRefPubMed
30.
Kang SW, Yoon I, Lee HW, Cho J. Association between AMELX polymorphisms and dental caries in Koreans. Oral Dis. 2011;17(4):399–406.CrossRefPubMed
31.
Patir A, Seymen F, Yildirim M, Deeley K, Cooper ME, Marazita ML, Vieira AR. Enamel formation genes are associated with high caries experience in Turkish children. Caries Res. 2008;42(5):394–400.CrossRefPubMedPubMedCentral
32.
Tannure PN, Kuchler EC, Lips A, Costa Mde C, Luiz RR, Granjeiro JM, Vieira AR. Genetic variation in MMP20 contributes to higher caries experience. J Dent. 2012;40(5):381–6.CrossRefPubMedPubMedCentral
33.
Quesada JM, Casado A, Diaz C, Barrios L, Cuenca-Acevedo R, Dorado G. Allele-frequency determination of BsmI and FokI polymorphisms of the VDR gene by quantitative real-time PCR (QRT-PCR) in pooled genomic DNA samples. J Steroid Biochem Mol Biol. 2004;89-90(1–5):209–14.CrossRefPubMed
34.
Hu XP, Li ZQ, Zhou JY, Yu ZH, Zhang JM, Guo ML. Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population. Genet Mol Res. 2015;14(3):11631–8.CrossRefPubMed
35.
Bayram M, Deeley K, Reis MF, Trombetta VM, Ruff TD, Sencak RC, Hummel M, Dizak PM, Washam K, Romanos HF, et al. Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions. Eur J Oral Sci. 2015;123:327–34.CrossRef
36.
Borilova Linhartova P, Kastovsky J, Bartosova M, Musilova K, Zackova L, Kukletova M, Kukla L, Izakovicova Holla L. ACE insertion/deletion polymorphism associated with caries in permanent but not primary dentition in Czech children. Caries Res. 2016;50(2):89–96.CrossRefPubMed
37.
Cogulu D, Onay H, Ozdemir Y, Aslan GI, Ozkinay F, Eronat C. The role of vitamin D receptor polymorphisms on dental caries. J Clin Pediatr Dent. 2016;40(3):211–4.CrossRefPubMed
38.
Izakovicova Holla L, Borilova Linhartova P, Kastovsky J, Bartosova M, Musilova K, Kukla L, Kukletova M. Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children. Caries Res. 2016;51(1):7–11.CrossRefPubMed
Metadata
Title
The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children
Authors
Yuan-yuan Kong
Jian-mao Zheng
Wen-juan Zhang
Qian-zhou Jiang
Xue-chao Yang
Miao Yu
Su-juan Zeng
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2017
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-017-0398-x

Other articles of this Issue 1/2017

BMC Oral Health 1/2017 Go to the issue

Research article

Comparison of diagnostic methods for early interproximal caries detection with near-infrared light transillumination: an in vivo study

Research article

Inequality in unmet dental care needs among South Korean adults

Research article

Five years’ follow-up of dental fear and anxiety, experience of dental care and oral health behaviour in Swedish preterm and full-term adolescents

Research article

Patient-reported negative experiences related to caries and its treatment among Swedish adult patients

Research article

Salivary pellets induce a pro-inflammatory response involving the TLR4–NF-kB pathway in gingival fibroblasts

Research article

Clinical applications and effectiveness of guided implant surgery: a critical review based on randomized controlled trials