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BMC Oral Health
Published in: BMC Oral Health 1/2017

Open Access 01-12-2017 | Research article

Effect of platelet rich fibrin on edema and pain following third molar surgery: a split mouth control study

Authors: Uğur Gülşen, Mehmet Fatih Şentürk

Published in: BMC Oral Health | Issue 1/2017

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Abstract

Background

To evaluate the efficacy of platelet-rich fibrine (PRF) on postoperative edema and pain after impacted mandibular third molar surgery.

Methods

The prospective study was comprised 30 patients who presented for the removal of bilateral impacted mandibular third molar teeth. After extraction, the sockets were filled with PRF or without PRF in the study and control groups, respectively. Postoperative edema was measured with a flexible tape measure by calculating the distance between several facial landmarks on postoperative days two and seven. Postoperative pain was evaluated with a line-type visual analogue scale (VAS) and a verbal scale (VRS). SPSS version 20.0 was used for data analysis.

Results

Both groups recorded significant improvement compared to the baseline levels in almost all of the outcome variables. There was no statistically significant difference between the study and control groups (p > 0.05).

Conclusions

Using or not using PRF to reduce postoperative pain and edema in third molar surgery was equally successful.

Trial registration

This study was retrospectively registered at the ISRCTN registry (ISRCTN16849867) on 6 March 2017.
Literature
1.
Bui CH, Seldin EB, Dodson TB. Types, frequencies, and risk factors for complications after third molar extraction. J Oral Maxillofac Surg. 2003;61:1379–89.CrossRefPubMed
2.
Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C. Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal. 2008;13(2):E129–32.PubMed
3.
Ogundipe OK, Ugboko VI, Owotade FJ. Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg. 2011;69:2305–10.CrossRefPubMed
4.
Uyanık LO, Bilginaylar K, Etikan İ. Effects of platelet-rich fibrin and piezosurgery on impacted mandibular third molar surgery outcomes. Head Face Med. 2015;11:25–32.CrossRefPubMedPubMedCentral
5.
Romeo U, Libotte F, Palaia G, Tenore G, Galanakis A, Annibali S. Is Er:YAG laser vs conventional rotary osteotomy better in the post operative period for lower third molar surgery? Randomized split mouth clinical study. Oral Maxillofac Surg. 2015;73(2):211–8.CrossRef
6.
Laureano Filho JR, De Oliveira e Silva ED, Batista CI, Gouveia FM. The influence of cryotherapy on swelling, pain and trismus after third-molar extraction. J Am Dent Assoc. 2005;136(6):774–8.CrossRefPubMed
7.
Olurotimi AO, Gbotolorun OM, Ibikunle AA, Emeka CI, Arotiba GT, Akinwande JA. A comparative clinical evaluation of the effects of preoperative and postoperative antimicrobial therapy on postoperative sequelae after ımpacted mandibular third molar extraction. J Oral Maxillofac Res. 2014;5(2):2.
8.
Dolanmaz D, Esen A, Isik K, Candirli C. Effect of 2 flap designs on postoperative pain and swelling after impacted third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(4):e244–6.CrossRefPubMed
9.
Barone A, Marconcini S, Giacomelli L, Rispoli L, Calvo JL, Covani U. A randomized clinical evaluation of ultrasound bone surgery versus traditional rotary ınstruments in lower third molar extraction. J Oral Maxillofac Surg. 2010;68:330–6.CrossRefPubMed
10.
Choukroun J, Adda F, Schoeffler C, Vervelle A. Uneopportunite´ en paro-implantologie: le PRF. Implantodontie. 2001;42:55–62.
11.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56–60.CrossRefPubMed
12.
Dohan DM, Choukroun J, Diss A. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:E37–44.CrossRefPubMed
13.
Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol. 2009;80:244–52.CrossRefPubMed
14.
Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant Dent. 2009;18:102–11.CrossRefPubMed
15.
Eshghpour M, Dastmalchi P, Nekooei AH, Nejat A. Effect of platelet rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: A double blinded randomized clinical trial. J Oral Maxillofac Surg. 2014;72:1463–7.CrossRefPubMed
16.
Altintas NY, Senel FC, Kayıpmaz S, Taşkesen F, Pampu AA. Comparative radiologic analyses of newly formed bone after maxillary sinus augmentation with and without bone grafting. J Oral Maxillofac Surg. 2013;71:1520–30.CrossRefPubMed
17.
Gülşen U, Şentürk MF, Mehdiyev İ. Flapless treatment of oro antral communication with platelet rich fibrin. Br J Oral Maxillofac Surg. 2016;54(6):702–3.CrossRefPubMed
18.
Kumar N, Prasad K, Ramanujam L, Ranganath K, Dexith J, Chauhan A. Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fi brin: A randomized controlled clinical study. J Oral Maxillofac Surg. 2015;73:1042–9.CrossRefPubMed
19.
Pasqualini D, Cocero N, Castella A, Mela L, Bracco P. Primary and secondary closure of the surgical wound after removal of impacted mandibular third molars: A comparative study. Int J Oral Maxillofac Surg. 2005;34:52–7.CrossRefPubMed
20.
21.
Ozgul O, Senses F, Er N, Tekin U, Tuz HH, Alkan A, Koçyiğit ID, Atıl F. Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial. Head Face Med. 2015;11:37–41.CrossRefPubMedPubMedCentral
22.
Bilginaylar K, Uyanik LO. Evaluation of the effects of platelet-rich fibrin and piezosurgery on outcomes after removal of ımpacted mandibular third molars. Br J Oral Maxillofac Surg. 2016;54(6):629–33.CrossRefPubMed
23.
Asutay F, Yolcu Ü, Geçör O, Acar AH, Öztürk SA, Malkoç S. An evaluation of effects of platelet‑rich‑fibrin on postoperative morbidities after lower third molar surgery. Niger J Clin Pract. DOI: 10.​4103/​1119-3077.​181400, 2016.
24.
Gürler G, Delilbaşı Ç, Kaçar İ, Öğüt E. Evaluation of leukocyte-platelet rich fibrin (L-PRF) on postoperative complications following mandibular impacted third molar surgery. Yeditepe Clinical Journal. 2015;1:11–6.
Metadata
Title
Effect of platelet rich fibrin on edema and pain following third molar surgery: a split mouth control study
Authors
Uğur Gülşen
Mehmet Fatih Şentürk
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2017
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-017-0371-8

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