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Published in: BMC Oral Health 1/2016

Open Access 01-12-2016 | Research article

Low vitamin D status strongly associated with periodontitis in Puerto Rican adults

Authors: Orlando J. Abreu, Dimitris N. Tatakis, Augusto R. Elias-Boneta, Lydia López Del Valle, Rafael Hernandez, Maria S. Pousa, Cristina Palacios

Published in: BMC Oral Health | Issue 1/2016

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Abstract

Background

Periodontitis and vitamin D deficiency are both highly prevalent in Puerto Rico. The aim of this pilot study was to evaluate the association between vitamin D levels and periodontal disease in Puerto Rican adults.

Methods

A sex-, age-, and BMI-matched case-control, cross-sectional study was conducted on 24 cases of moderate/severe periodontitis and 24 periodontally healthy controls aged 35 to 64 years. Each participant completed a socio-demographic questionnaire, underwent a full-mouth periodontal examination and provided blood sample to measure serum 25-hydroxyvitamin D (25 (OH) D) levels to assess vitamin D status.

Results

A total of 19 matched case-control pairs (28 females, 10 males) completed the study. Mean serum 25 (OH) D levels were significantly lower in cases (18.5 ± 4.6 ng/ml) than in controls (24.2 ± 7.1 ng/ml; p = 0.006). Lower odds of periodontal disease were observed per unit of 25 (OH) D level (OR 0.885; 95 % CI 0.785, 0.997; p < 0.05).

Conclusions

Lower serum vitamin D levels are significantly associated with periodontitis in Puerto Rican adults.
Literature
1.
go back to reference Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am. 2005;49(3):491–516.CrossRefPubMed Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am. 2005;49(3):491–516.CrossRefPubMed
2.
go back to reference Philstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–20.CrossRef Philstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–20.CrossRef
3.
go back to reference Eke PI, Dye BA, Wei L, et al. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914–20.CrossRefPubMed Eke PI, Dye BA, Wei L, et al. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914–20.CrossRefPubMed
4.
go back to reference Montero-Aguilar M, Muñoz-Torres F, Elías-Boneta AR, Dye B, Joshipura KJ. High levels of periodontal disease among the older adult population in San Juan, Puerto Rico. Commun Dent Health. 2012;29:224–8. Montero-Aguilar M, Muñoz-Torres F, Elías-Boneta AR, Dye B, Joshipura KJ. High levels of periodontal disease among the older adult population in San Juan, Puerto Rico. Commun Dent Health. 2012;29:224–8.
5.
go back to reference Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari H. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr. 2005;82:575–80.PubMed Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari H. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr. 2005;82:575–80.PubMed
6.
8.
go back to reference Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy Press; 2010. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy Press; 2010.
9.
go back to reference Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.CrossRefPubMed Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.CrossRefPubMed
10.
go back to reference Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25 (OH) D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.PubMed Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25 (OH) D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.PubMed
11.
go back to reference Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr. 2004;80:108–13.PubMed Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr. 2004;80:108–13.PubMed
12.
go back to reference Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt:138–45.CrossRef Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt:138–45.CrossRef
13.
go back to reference Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr. 2012;142:498–507.CrossRefPubMed Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr. 2012;142:498–507.CrossRefPubMed
14.
go back to reference Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30:771–7.CrossRefPubMed Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30:771–7.CrossRefPubMed
15.
16.
go back to reference Oliveri B, Plantalech L, Bagur A, et al. High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina. Eur J Clin Nutr. 2004;58:337–42.CrossRefPubMed Oliveri B, Plantalech L, Bagur A, et al. High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina. Eur J Clin Nutr. 2004;58:337–42.CrossRefPubMed
17.
go back to reference Reasner 2nd CA, Dunn JF, Fetchick DA, et al. Alteration of vitamin D metabolism in Mexican-Americans. J Bone Miner Res. 1990;5:13–7.CrossRefPubMed Reasner 2nd CA, Dunn JF, Fetchick DA, et al. Alteration of vitamin D metabolism in Mexican-Americans. J Bone Miner Res. 1990;5:13–7.CrossRefPubMed
18.
go back to reference Levis S, Gomez A, Jimenez C, et al. Vitamin D deficiency and seasonal variation in an adult south Florida population. J Clin Endocrinol Metab. 2005;90:1557–62.CrossRefPubMed Levis S, Gomez A, Jimenez C, et al. Vitamin D deficiency and seasonal variation in an adult south Florida population. J Clin Endocrinol Metab. 2005;90:1557–62.CrossRefPubMed
19.
go back to reference Araujo AB, Travison TG, Esche GR, Holick MF, Chen TC, McKinlay JB. Serum 25-hydroxyvitamin D and bone mineral density among Hispanic men. Osteoporos Int. 2009;20(2):245–55.CrossRefPubMed Araujo AB, Travison TG, Esche GR, Holick MF, Chen TC, McKinlay JB. Serum 25-hydroxyvitamin D and bone mineral density among Hispanic men. Osteoporos Int. 2009;20(2):245–55.CrossRefPubMed
20.
go back to reference Suárez-Martínez EB, Cruz SK, Khorsandi S, Chardón C, Ferder L. Importance of vitamin D and vitamin D levels status in Puerto Ricans. J Health Care Poor Underserved. 2013;24(4 Suppl):38–47.PubMedPubMedCentral Suárez-Martínez EB, Cruz SK, Khorsandi S, Chardón C, Ferder L. Importance of vitamin D and vitamin D levels status in Puerto Ricans. J Health Care Poor Underserved. 2013;24(4 Suppl):38–47.PubMedPubMedCentral
21.
go back to reference Ramos-Trautmann G, González L, Díaz-Luquis G, M. Pérez C, Palacios C. Inverse association between vitamin D status and diabetes in a clinic based sample of Hispanic adults in Puerto Rico. Diab Res Open J. 2015;1:5–11.CrossRef Ramos-Trautmann G, González L, Díaz-Luquis G, M. Pérez C, Palacios C. Inverse association between vitamin D status and diabetes in a clinic based sample of Hispanic adults in Puerto Rico. Diab Res Open J. 2015;1:5–11.CrossRef
22.
go back to reference Gursoy UK, Liukkonen J, Jula A, Huumonen S, Suominen AL, Puukka P, Könönen E. Associations between salivary bone metabolism markers and periodontal breakdown. J Periodontol. 2016;87(4):367–75.CrossRefPubMed Gursoy UK, Liukkonen J, Jula A, Huumonen S, Suominen AL, Puukka P, Könönen E. Associations between salivary bone metabolism markers and periodontal breakdown. J Periodontol. 2016;87(4):367–75.CrossRefPubMed
23.
go back to reference Bokhari SA, Khan AA, Butt AK, Azhar M, Hanif M, Izhar M, Tatakis DN. Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol. 2012;39(11):1065–74.CrossRefPubMed Bokhari SA, Khan AA, Butt AK, Azhar M, Hanif M, Izhar M, Tatakis DN. Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol. 2012;39(11):1065–74.CrossRefPubMed
24.
go back to reference Lorentz TC, Cota LO, Cortelli JR, Vargas AM, Costa FO. Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis. J Clin Periodontol. 2009;36(1):58–67.CrossRefPubMed Lorentz TC, Cota LO, Cortelli JR, Vargas AM, Costa FO. Prospective study of complier individuals under periodontal maintenance therapy: analysis of clinical periodontal parameters, risk predictors and the progression of periodontitis. J Clin Periodontol. 2009;36(1):58–67.CrossRefPubMed
25.
go back to reference Papantonopoulos GH. Effect of periodontal therapy in smokers and non-smokers with advanced periodontal disease: results after maintenance therapy for a minimum of 5 years. J Periodontol. 2004;75(6):839–43.CrossRefPubMed Papantonopoulos GH. Effect of periodontal therapy in smokers and non-smokers with advanced periodontal disease: results after maintenance therapy for a minimum of 5 years. J Periodontol. 2004;75(6):839–43.CrossRefPubMed
26.
go back to reference Page RC, Eke PI. Case definitions for use in populations-based surveillance of periodontitis. J Periodontol. 2007;78:1387–99.CrossRefPubMed Page RC, Eke PI. Case definitions for use in populations-based surveillance of periodontitis. J Periodontol. 2007;78:1387–99.CrossRefPubMed
27.
go back to reference Boggess KA, Espinola JA, Moss K, Beck J, Offenbacher S, Camargo Jr CA. Vitamin D status and periodontal disease among pregnant women. J Periodontol. 2011;82:195–200.CrossRefPubMed Boggess KA, Espinola JA, Moss K, Beck J, Offenbacher S, Camargo Jr CA. Vitamin D status and periodontal disease among pregnant women. J Periodontol. 2011;82:195–200.CrossRefPubMed
28.
go back to reference Jimenez M, Giovannucci E, Krall Kaye E, Joshipura KJ, Dietrich T. Predicted vitamin D status and incidence of tooth loss and periodontitis. Public Health Nutr. 2014;17:844–52.CrossRefPubMed Jimenez M, Giovannucci E, Krall Kaye E, Joshipura KJ, Dietrich T. Predicted vitamin D status and incidence of tooth loss and periodontitis. Public Health Nutr. 2014;17:844–52.CrossRefPubMed
29.
go back to reference Antonoglou GN, Knuuttila M, Niemelä O, et al. Low serum level of 1, 25 (OH) 2 D is associated with chronic periodontitis. J Periodont Res. 2015;50:274–80.CrossRefPubMed Antonoglou GN, Knuuttila M, Niemelä O, et al. Low serum level of 1, 25 (OH) 2 D is associated with chronic periodontitis. J Periodont Res. 2015;50:274–80.CrossRefPubMed
30.
go back to reference Purvis R. Enamel hypoplasia of the teeth associated with neonatal tetany: a manifestation of maternal vitamin-D deficiency. Lancet. 1973;302:811–4.CrossRef Purvis R. Enamel hypoplasia of the teeth associated with neonatal tetany: a manifestation of maternal vitamin-D deficiency. Lancet. 1973;302:811–4.CrossRef
31.
go back to reference Diamond G, Yim S, Rigo I, McMahon L. Measuring antimicrobial peptide activity on epithelial surfaces in cell culture. Methods Mol Biol. 2010;618:371–82.CrossRefPubMedPubMedCentral Diamond G, Yim S, Rigo I, McMahon L. Measuring antimicrobial peptide activity on epithelial surfaces in cell culture. Methods Mol Biol. 2010;618:371–82.CrossRefPubMedPubMedCentral
32.
go back to reference Hiremath VP, Rao CB, Naik V, Prasad KV. Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health Prev Dent. 2013;11:61–9.PubMed Hiremath VP, Rao CB, Naik V, Prasad KV. Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health Prev Dent. 2013;11:61–9.PubMed
33.
34.
go back to reference Guillot X, Semerano L, Saidenberg-Kermanac’h N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine. 2010;77:552–7.CrossRefPubMed Guillot X, Semerano L, Saidenberg-Kermanac’h N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine. 2010;77:552–7.CrossRefPubMed
Metadata
Title
Low vitamin D status strongly associated with periodontitis in Puerto Rican adults
Authors
Orlando J. Abreu
Dimitris N. Tatakis
Augusto R. Elias-Boneta
Lydia López Del Valle
Rafael Hernandez
Maria S. Pousa
Cristina Palacios
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2016
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-016-0288-7

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