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BMC Endocrine Disorders
Published in: BMC Endocrine Disorders 1/2018

Open Access 01-12-2018 | Research article

Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis

Authors: Semi Hwang, Jung-eun Lim, Yoonjeong Choi, Sun Ha Jee

Published in: BMC Endocrine Disorders | Issue 1/2018

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Abstract

Background

This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations.

Methods

The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models.

Results

A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31).

Conclusions

This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans.
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Metadata
Title
Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis
Authors
Semi Hwang
Jung-eun Lim
Yoonjeong Choi
Sun Ha Jee
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Endocrine Disorders / Issue 1/2018
Electronic ISSN: 1472-6823
DOI
https://doi.org/10.1186/s12902-018-0310-y

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