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Open Access 01-12-2015 | Research article

C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes

Authors: Danfeng Peng, Jie Wang, Rong Zhang, Shanshan Tang, Feng Jiang, Miao Chen, Jing Yan, Xue Sun, Tao Wang, Shiyun Wang, Yuqian Bao, Cheng Hu, Weiping Jia

Published in: BMC Endocrine Disorders | Issue 1/2015

Abstract

Background

Diabetic retinopathy (DR) is an important microvascular complication of diabetes with a high concordance rate in patients with diabetes. Inflammation is supposed to participate in the development of DR. This study aimed to investigate whether genetic variants of CRP are associated with DR.

Methods

A total of 1,018 patients with type 2 diabetes were recruited in this study. Of these patients, 618 were diagnosed with DR, 400 were patients with diabetes for over 10 years but without DR, considered as cases and controls for DR, respectively. Four tagging SNPs (rs2808629, rs3093077, rs1130864 and rs2808634) within CRP region were genotyped for all the participants. Fundus photography was performed for diagnosis and classification for DR.

Results

rs2808629 was significantly associated with increased susceptibility to DR (odds ratio 1.296, 95% CI 1.076-1.561, P = 0.006, empirical P = 0.029, for G allele). This association remained significant after adjustment for confounding factors (odds ratio 1.261, 95% CI 1.022-1.555, P = 0.030).

Conclusions

In this study, we found CRP rs2808629 was associated with DR in the Chinese patients with type 2 diabetes.

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Title: C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes
Authors: Danfeng Peng
Jie Wang
Rong Zhang
Shanshan Tang
Feng Jiang
Miao Chen
Jing Yan
Xue Sun
Tao Wang
Shiyun Wang
Yuqian Bao
Cheng Hu
Weiping Jia
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Endocrine Disorders / Issue 1/2015
Electronic ISSN: 1472-6823
DOI: https://doi.org/10.1186/s12902-015-0006-5

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C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes

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Conclusions

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