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BMC Ear, Nose and Throat Disorders
Published in: BMC Ear, Nose and Throat Disorders 1/2015

Open Access 01-12-2015 | Research article

Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media

Authors: Katsuhisa Ikeda, Shigeki Misawa, Takeshi Kusunoki

Published in: BMC Ear, Nose and Throat Disorders | Issue 1/2015

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Abstract

Background

The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM).

Methods

We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains).

Results

STFX exhibited the most potent activity of both MIC50 and MIC90, followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05).

Conclusion

STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa.
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Metadata
Title
Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
Authors
Katsuhisa Ikeda
Shigeki Misawa
Takeshi Kusunoki
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Ear, Nose and Throat Disorders / Issue 1/2015
Electronic ISSN: 1472-6815
DOI
https://doi.org/10.1186/s12901-015-0018-9

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