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BMC Urology
Published in: BMC Urology 1/2021

Open Access 01-12-2021 | Overactive Bladder | Research article

A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome

Authors: Kiren Gill, Harry Horsley, Sheela Swamy, Rajvinder Khasriya, James Malone-Lee

Published in: BMC Urology | Issue 1/2021

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Abstract

Background

Contemporary studies have discredited the methods used to exclude urinary tract infection (UTI) when treating overactive bladder (OAB). Thus we must revisit the OAB phenotype to check that UTI has not been overlooked.

Aims

To examine the differences in urinary cytokines IL6 and lactoferrin in OAB patients compared to controls, with references to microscopy of urine and enhanced quantitative urine culture.

Methods

A blinded, prospective cohort study with normal controls using six repeated measures, achieved two-monthly, over 12 months.

Results

The differences between patients and controls in urine IL6 (F = 49.0, p < .001) and lactoferrin (F = 228.5, p < .001) were significant and of a magnitude to have clinical implications. These differences were for lactoferrin correlated to symptoms (9.3, p = .003); for both to pyuria (IL6 F = 66.2, p < .001, Lactoferrin F = 73.9, p < .001); and for IL6 microbial abundance (F = 5.1, p = .024). The pathological markers had been missed by urinary dipsticks and routine MSU culture.

Conclusion

The OAB phenotype may encompass patients with UTI that is being overlooked because of the failure of standard screening methods.
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Metadata
Title
A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome
Authors
Kiren Gill
Harry Horsley
Sheela Swamy
Rajvinder Khasriya
James Malone-Lee
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-021-00809-4

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