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BMC Urology

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Open Access 01-12-2020 | Research article

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

Authors: Jingqi Zhang, Xiaozhou Zhou, Hua Ding, Liwei Wang, Sha Liu, Yuting Liu, Zhiwen Chen

Published in: BMC Urology | Issue 1/2020

Abstract

Background

A routine blood examination is one of the most rapid, convenient and inexpensive clinical examinations that can reflect a patient’s inflammatory status and other blood conditions, and the prognostic value of routine preoperative blood parameters in MIBC patients is still unclear, so we evaluated the prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer (MIBC) following radical cystectomy (RC).

Methods

Data on 202 patients with MIBC who underwent RC at our institution were retrospectively collected between October 2007 and August 2018. The median preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (HGB) values were used as cutoffs to form the low and high NLR, low and high PLR, and low and high HGB groups, respectively. The clinicopathologic characteristics of each group were compared by chi-square and t tests. Kaplan-Meier survival and multivariate Cox regression analyses were used to analyze prognosis.

Results

The median NLR, PLR and HGB values were 2.42, 112 and 125 g/L, respectively. Kaplan-Meier results showed that the low HGB group had poor progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). A high NLR and high PLR groups correlated only with poor OS. Multivariate Cox analyses showed that pathological T3/4 stage, positive lymph node status and low HGB were independent risk factors for PFS, CSS and OS, and age was the only independent risk factor for OS.

Conclusion

Preoperative peripheral blood HGB is an independent risk factor for the prognosis of MIBC patients. These data suggest that HGB may be a useful prognostic marker for MIBC patients undergoing RC.

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Title: The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer
Authors: Jingqi Zhang
Xiaozhou Zhou
Hua Ding
Liwei Wang
Sha Liu
Yuting Liu
Zhiwen Chen
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: BMC Urology / Issue 1/2020
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-020-00602-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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