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BMC Urology
Published in: BMC Urology 1/2015

Open Access 01-12-2015 | Research article

PET/CT versus conventional CT for detection of lymph node metastases in patients with locally advanced bladder cancer

Authors: Firas Aljabery, Gunnar Lindblom, Susann Skoog, Ivan Shabo, Hans Olsson, Johan Rosell, Staffan Jahnson

Published in: BMC Urology | Issue 1/2015

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Abstract

Background

We studied patients treated with radical cystectomy for locally advanced bladder cancer to compare the results of both preoperative positron emission tomography/computed tomography (PET/CT) and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes.

Methods

Patients who had bladder cancer and were candidates for cystectomy underwent preoperative PET/CT using 18-fluorodeoxyglucose (FDG) and conventional CT. The results regarding lymph node involvement were independently evaluated by two experienced radiologists and were subsequently compared with histopathology results, the latter of which were reassessed by an experienced uropathologist (HO).

Results

There were 54 evaluable patients (mean age 68 years, 47 [85 %] males and 7 [15 %] females) with pT and pN status as follows: < pT2-14 (26 %), pT2-10 (18 %), and > pT2-30 (56 %); pN0 37 (69 %) and pN+ 17 (31 %). PET/CT showed positive lymph nodes in 12 patients (22 %), and 7 of those cases were confirmed by histopathology; the corresponding results for conventional CT were 11 (20 %) and 7 patients (13 %), respectively. PET/CT had 41 % sensitivity, 86 % specificity, 58 % PPV, and 76 % NPV, whereas the corresponding figures for conventional CT were 41 %, 89 %, 64 %, and 77 %. Additional analyses of the right and left side of the body or in specified anatomical regions gave similar results.

Conclusions

In this study, PET/CT and conventional CT had similar low sensitivity in detecting and localizing regional lymph node metastasis in bladder cancer.
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Metadata
Title
PET/CT versus conventional CT for detection of lymph node metastases in patients with locally advanced bladder cancer
Authors
Firas Aljabery
Gunnar Lindblom
Susann Skoog
Ivan Shabo
Hans Olsson
Johan Rosell
Staffan Jahnson
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2015
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-015-0080-z

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