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Published in: International Urology and Nephrology 6/2013

01-12-2013 | Urology – Review

Lymph node dissection during radical cystectomy for bladder cancer treatment: considerations on relevance and extent

Authors: Lars Weisbach, Roland Dahlem, Giuseppe Simone, Jens Hansen, Armin Soave, Oliver Engel, Felix K. Chun, Shahrokh F. Shariat, Margit Fisch, Michael Rink

Published in: International Urology and Nephrology | Issue 6/2013

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Abstract

Despite advances in the surgical and medical treatment for urothelial carcinoma of the bladder (UCB), there have only been limited improvements in disease-specific mortality rates over the past decades. Lymph node dissection (LND) during radical cystectomy is an integral part of the treatment for muscle-invasive and high-risk UCB. LND may detect and remove lymph node (LN) metastasis and thus guide patient counseling and decision making regarding additional treatment decisions. In addition, LND may improve survival in patients both with and without LN metastasis. In this non-systematic review article, we discuss benefits and risks of LND, the role of limited versus extended LND and the dilemma of preoperative LN staging.
Literature
1.
2.
go back to reference Ferlay J, Shin HR et al (2010) Estimates of worldwide burden of cancer in 2008: globocan 2008. Int J Cancer 127:2893–2917PubMedCrossRef Ferlay J, Shin HR et al (2010) Estimates of worldwide burden of cancer in 2008: globocan 2008. Int J Cancer 127:2893–2917PubMedCrossRef
3.
go back to reference Shariat SF, Palapattu GS, Amiel GE et al (2006) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 176(6 Pt 1):2414–2422PubMedCrossRef Shariat SF, Palapattu GS, Amiel GE et al (2006) Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium. J Urol 176(6 Pt 1):2414–2422PubMedCrossRef
4.
go back to reference Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19:666–675PubMed Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19:666–675PubMed
5.
go back to reference Madersbacher S et al (2003) Radical cystectomy for bladder cancer today—a homogeneous series without neoadjuvant therapy. J Clin Oncol 21(4):690–696PubMedCrossRef Madersbacher S et al (2003) Radical cystectomy for bladder cancer today—a homogeneous series without neoadjuvant therapy. J Clin Oncol 21(4):690–696PubMedCrossRef
6.
go back to reference Shariat SF, Rink M, Ehdaie B et al (2013) Pathological nodal staging score for bladder cancer: a decision tool for adjuvant therapy after radical cystectomy. Eur Urol 63:371–378PubMedCrossRef Shariat SF, Rink M, Ehdaie B et al (2013) Pathological nodal staging score for bladder cancer: a decision tool for adjuvant therapy after radical cystectomy. Eur Urol 63:371–378PubMedCrossRef
7.
go back to reference Kassouf W, Svatek RS, Shariat SF et al (2013) Critical analysis and validation of lymph node density as prognostic variable in urothelial carcinoma of the bladder. Urol Oncol 31(4):480–486 Kassouf W, Svatek RS, Shariat SF et al (2013) Critical analysis and validation of lymph node density as prognostic variable in urothelial carcinoma of the bladder. Urol Oncol 31(4):480–486
8.
go back to reference Rink M, Hansen J, Cha E, Shariat SF et al (2013) Outcomes and prognostic factors in patients with a single lymph node metastasis at time of radical cystectomy. BJU Int 111(1):74–84PubMedCrossRef Rink M, Hansen J, Cha E, Shariat SF et al (2013) Outcomes and prognostic factors in patients with a single lymph node metastasis at time of radical cystectomy. BJU Int 111(1):74–84PubMedCrossRef
9.
go back to reference Bruins HM, Huang GJ, Cai J, Skinner DG, Stein JP, Penson DF (2009) Clinical outcomes and recurrence predictors of lymph node positive urothelial cancer after cystectomy. J Urol 182:2182–2187PubMedCrossRef Bruins HM, Huang GJ, Cai J, Skinner DG, Stein JP, Penson DF (2009) Clinical outcomes and recurrence predictors of lymph node positive urothelial cancer after cystectomy. J Urol 182:2182–2187PubMedCrossRef
10.
go back to reference Herr HW, Bochner BH, Dalbagni G, Donat SM, Reuter VE, Bajorin DF (2002) Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol 167:1295–1298PubMedCrossRef Herr HW, Bochner BH, Dalbagni G, Donat SM, Reuter VE, Bajorin DF (2002) Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol 167:1295–1298PubMedCrossRef
11.
go back to reference Karl A, Carroll PR, Gschwend JE et al (2009) The impact of lymphadenectomy and lymph node metastasis on the outcomes of radical cystectomy for bladder cancer. Eur Urol 55:826–835PubMedCrossRef Karl A, Carroll PR, Gschwend JE et al (2009) The impact of lymphadenectomy and lymph node metastasis on the outcomes of radical cystectomy for bladder cancer. Eur Urol 55:826–835PubMedCrossRef
12.
go back to reference Konety BR, Joslyn SA, O’ Donnell MA (2003) Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: analysis of data from the Surveillance, epidemiology and end results program data base. J Urol 169:946–950PubMedCrossRef Konety BR, Joslyn SA, O’ Donnell MA (2003) Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: analysis of data from the Surveillance, epidemiology and end results program data base. J Urol 169:946–950PubMedCrossRef
13.
go back to reference Mills RD, Turner WH, Fleischmann A, Markwalder R, Thalmann GN, Studer UE (2001) Pelvic lymph node metastases from bladder cancer: outcome in 83 patients after radical cystectomy and pelvic lymphadenectomy. J Urol 166:19–23PubMedCrossRef Mills RD, Turner WH, Fleischmann A, Markwalder R, Thalmann GN, Studer UE (2001) Pelvic lymph node metastases from bladder cancer: outcome in 83 patients after radical cystectomy and pelvic lymphadenectomy. J Urol 166:19–23PubMedCrossRef
14.
go back to reference Stein JP, Cai J, Groshen S, Skinner DG (2003) Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol 170:35–41PubMedCrossRef Stein JP, Cai J, Groshen S, Skinner DG (2003) Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol 170:35–41PubMedCrossRef
15.
go back to reference Vieweg J, Gschwend JE, Herr HW, Fair WR (1999) The impact of primary stage on survival in patients with lymph node positive bladder cancer. J Urol 161:72–76PubMedCrossRef Vieweg J, Gschwend JE, Herr HW, Fair WR (1999) The impact of primary stage on survival in patients with lymph node positive bladder cancer. J Urol 161:72–76PubMedCrossRef
16.
go back to reference Stenzl A, Cowan NC, De Santis M, Jakse G, Kuczyk MA, Merseburger AS, Ribal MJ, Sherif A, Witjes JA (2010) European Association of Urology. Update of the clinical guidelines of the European Association of Urology on muscle invasive and metastatic bladder carcinoma. Actas Urol Esp 34:51–62PubMedCrossRef Stenzl A, Cowan NC, De Santis M, Jakse G, Kuczyk MA, Merseburger AS, Ribal MJ, Sherif A, Witjes JA (2010) European Association of Urology. Update of the clinical guidelines of the European Association of Urology on muscle invasive and metastatic bladder carcinoma. Actas Urol Esp 34:51–62PubMedCrossRef
17.
go back to reference Shariat SF, Palapattu GS, Karakiewicz PI et al (2007) Discrepancy between clinical and pathological stage: impact on prognosis after radical cystectomy. Eur Urol 51:137–151PubMedCrossRef Shariat SF, Palapattu GS, Karakiewicz PI et al (2007) Discrepancy between clinical and pathological stage: impact on prognosis after radical cystectomy. Eur Urol 51:137–151PubMedCrossRef
19.
go back to reference Sherif A, Garske U, de la Torre M, Thörn M (2006) Hybrid SPECT-CT:an additional technique for sentinel node detection of patients with invasive bladder cancer. Eur Urol 50:83–91PubMedCrossRef Sherif A, Garske U, de la Torre M, Thörn M (2006) Hybrid SPECT-CT:an additional technique for sentinel node detection of patients with invasive bladder cancer. Eur Urol 50:83–91PubMedCrossRef
20.
go back to reference Liedberg F, Chebil G, Davidsson T, Gudjonnson S, Mansson W (2006) Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol 175:84–88PubMedCrossRef Liedberg F, Chebil G, Davidsson T, Gudjonnson S, Mansson W (2006) Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol 175:84–88PubMedCrossRef
21.
go back to reference Machtens S, Serth J, Meyer A, Kleinhorst C, Ommer KJ, Herbst U, Kieruij M, Boerner AR (2007) Positron emission tomography (PET) in the urooncological evaluation of the small pelvis. World J Urol 4:341–349CrossRef Machtens S, Serth J, Meyer A, Kleinhorst C, Ommer KJ, Herbst U, Kieruij M, Boerner AR (2007) Positron emission tomography (PET) in the urooncological evaluation of the small pelvis. World J Urol 4:341–349CrossRef
23.
go back to reference Stenzl A, Cowan NC, De Santis M et al (2011) Treatment of muscle invasive and metastatic bladder cancer: update of the EAU Guidelines. Eur J Urol 59:1009–1018CrossRef Stenzl A, Cowan NC, De Santis M et al (2011) Treatment of muscle invasive and metastatic bladder cancer: update of the EAU Guidelines. Eur J Urol 59:1009–1018CrossRef
24.
go back to reference Skinner DG (1982) Management of invasive bladder cancer: a meticulous pelvic node dissection can make a difference. J Urol 128:34–36PubMed Skinner DG (1982) Management of invasive bladder cancer: a meticulous pelvic node dissection can make a difference. J Urol 128:34–36PubMed
25.
go back to reference Dorin RP, Skinner EC (2010) Extended lymphadenectomy in bladder cancer. Curr Opin Urol 20:414–420PubMedCrossRef Dorin RP, Skinner EC (2010) Extended lymphadenectomy in bladder cancer. Curr Opin Urol 20:414–420PubMedCrossRef
26.
go back to reference Stein JP (2007) The role of lymphadenectomy in patients undergoing radical cystectomy for bladder cancer. Curr Oncol Rep 9:213–221PubMedCrossRef Stein JP (2007) The role of lymphadenectomy in patients undergoing radical cystectomy for bladder cancer. Curr Oncol Rep 9:213–221PubMedCrossRef
27.
go back to reference Stein JP, Skinner DG (2004) Surgical atlas radical cystectomy. BJU Int 94:97–121CrossRef Stein JP, Skinner DG (2004) Surgical atlas radical cystectomy. BJU Int 94:97–121CrossRef
28.
go back to reference Roth B, Wissmayer MP, Zehnder P et al (2010) A new multimodality technique accurately maps the primary lymphatic landing sites of the bladder. Eur Urol 57:205–211PubMedCrossRef Roth B, Wissmayer MP, Zehnder P et al (2010) A new multimodality technique accurately maps the primary lymphatic landing sites of the bladder. Eur Urol 57:205–211PubMedCrossRef
29.
go back to reference Vazina A, Dugi D, Shariat SF, Evans J, Link R, Lerner R, Lerner SP (2004) Stage specific lymph node metastasis mapping in radical cystectomy specimen. J Urol 171:1830–1834PubMedCrossRef Vazina A, Dugi D, Shariat SF, Evans J, Link R, Lerner R, Lerner SP (2004) Stage specific lymph node metastasis mapping in radical cystectomy specimen. J Urol 171:1830–1834PubMedCrossRef
30.
go back to reference Abol-Enein H, El-Baz M, Abd-El-Hameed MA, Abdel-Latif M, Ghonheim MA (2004) Lymph node involvement in patients with bladder cancer treated with radical cystectomy: a patho-anatomical study—a single center experience. J Urol 172:1818–1821PubMedCrossRef Abol-Enein H, El-Baz M, Abd-El-Hameed MA, Abdel-Latif M, Ghonheim MA (2004) Lymph node involvement in patients with bladder cancer treated with radical cystectomy: a patho-anatomical study—a single center experience. J Urol 172:1818–1821PubMedCrossRef
31.
go back to reference Leissner J, Ghoneim MA, Abol-Enein H et al (2004) Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol 171:139–144PubMedCrossRef Leissner J, Ghoneim MA, Abol-Enein H et al (2004) Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol 171:139–144PubMedCrossRef
32.
go back to reference Seiler R, von Gunten M, Thlmann GN, Fleischmann A (2010) Pelvic lymph nodes: distribution and nodal tumour burden of urothelial bladder cancer. J Clin Pathol 63:504–507PubMedCrossRef Seiler R, von Gunten M, Thlmann GN, Fleischmann A (2010) Pelvic lymph nodes: distribution and nodal tumour burden of urothelial bladder cancer. J Clin Pathol 63:504–507PubMedCrossRef
33.
go back to reference Dorin RP, Daneshmand S, Skinner EC et al (2011) Lymph node dissection technique is more important than lymph node count in identifying nodal metastases in radical cystectomy patients: a comparative mapping study. Eur Urol 60:946–952PubMedCrossRef Dorin RP, Daneshmand S, Skinner EC et al (2011) Lymph node dissection technique is more important than lymph node count in identifying nodal metastases in radical cystectomy patients: a comparative mapping study. Eur Urol 60:946–952PubMedCrossRef
34.
go back to reference Rink M, Cha EK, Green D, Shariat SF et al (2012) Biomolecular Predictors of Urothelial Cancer Behavior and Treatment Outcomes. Curr Urol Rep 13(2):122–135PubMedCrossRef Rink M, Cha EK, Green D, Shariat SF et al (2012) Biomolecular Predictors of Urothelial Cancer Behavior and Treatment Outcomes. Curr Urol Rep 13(2):122–135PubMedCrossRef
35.
go back to reference Burkhard FC, Roth B, Zehnder P, Studer UE (2011) Lymphadenectomy for bladder cancer: indications and controversies. Urol Clin North Am 38(4):397–405PubMedCrossRef Burkhard FC, Roth B, Zehnder P, Studer UE (2011) Lymphadenectomy for bladder cancer: indications and controversies. Urol Clin North Am 38(4):397–405PubMedCrossRef
36.
go back to reference Lerner SP, Skinner DG, Lieskovsky G et al (1993) The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long term results. J Urol 149:758–765PubMed Lerner SP, Skinner DG, Lieskovsky G et al (1993) The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long term results. J Urol 149:758–765PubMed
37.
go back to reference Vieweg J, Whitmore WF Jr, Herr HW et al (1994) The role of pelvic lymphadenectomy and radical cystectomy for lymph node positive bladder cancer. The Memorial Sloan Kettering Cancer Center experience. Cancer 73:3020–3028PubMedCrossRef Vieweg J, Whitmore WF Jr, Herr HW et al (1994) The role of pelvic lymphadenectomy and radical cystectomy for lymph node positive bladder cancer. The Memorial Sloan Kettering Cancer Center experience. Cancer 73:3020–3028PubMedCrossRef
38.
go back to reference May M, Herrmann E, Bolenz C et al (2011) Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy. Ann Surg Oncol 18:2018–2025PubMedCrossRef May M, Herrmann E, Bolenz C et al (2011) Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy. Ann Surg Oncol 18:2018–2025PubMedCrossRef
39.
go back to reference Herr HW, Faulkner JR, Grossmann HB et al (2004) Surgical factors influence bladder cancer outcomes: a cooperative group report. J Clin Oncol 22(14):2781–2789PubMedCrossRef Herr HW, Faulkner JR, Grossmann HB et al (2004) Surgical factors influence bladder cancer outcomes: a cooperative group report. J Clin Oncol 22(14):2781–2789PubMedCrossRef
40.
go back to reference Leissner J, Hohenfellner R, Thuroff JW, Wolf HK (2000) Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int 85:817–823PubMedCrossRef Leissner J, Hohenfellner R, Thuroff JW, Wolf HK (2000) Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int 85:817–823PubMedCrossRef
41.
go back to reference Simone G, Papalia R, Ferriero M, Guaglianone S, Castelli E, Collura D, Muto G, Gallucci M (2012) Stage specific impact of extended versus standard pelvic lymph node dissection in radical cystectomy. Int J Urol 20(4):1442–2042 Simone G, Papalia R, Ferriero M, Guaglianone S, Castelli E, Collura D, Muto G, Gallucci M (2012) Stage specific impact of extended versus standard pelvic lymph node dissection in radical cystectomy. Int J Urol 20(4):1442–2042
42.
go back to reference Dhar NB, Klein EA, Reuther AM, Thalmann GN, Madersbacher S, Studer UE (2008) Outcome after radical cystectomy with limited or extended pelvic lymph node dissection. J Urol 179:873–878PubMedCrossRef Dhar NB, Klein EA, Reuther AM, Thalmann GN, Madersbacher S, Studer UE (2008) Outcome after radical cystectomy with limited or extended pelvic lymph node dissection. J Urol 179:873–878PubMedCrossRef
43.
go back to reference Rink M, Shariat SF, Xylinas E (2012) Does increasing the nodal yield improve outcomes in patients without nodal metastasis at radical cystectomy? World J Urol 30(6):807–814PubMedCrossRef Rink M, Shariat SF, Xylinas E (2012) Does increasing the nodal yield improve outcomes in patients without nodal metastasis at radical cystectomy? World J Urol 30(6):807–814PubMedCrossRef
44.
go back to reference Tarin TV, Power NE, Bochner BH et al (2012) Lymph node-positive bladder cancer treated with radical cystectomy and lymphadenectomy: effect of the level of node positivity. Eur Urol 61:1025–1030PubMedCrossRef Tarin TV, Power NE, Bochner BH et al (2012) Lymph node-positive bladder cancer treated with radical cystectomy and lymphadenectomy: effect of the level of node positivity. Eur Urol 61:1025–1030PubMedCrossRef
45.
go back to reference Kurahashi T, Hara I, Oka N, Kamidono S, Eto H, Miyake H (2005) Detection of micrometastases in pelvic lymph nodes in patients undergoing radical cystectomy for locally invasive bladder cancer by real-time reverse transcriptase-PCR for cytokeratin 19 and uroplakin II. Clin Cancer Res 11(10):3773–3777PubMedCrossRef Kurahashi T, Hara I, Oka N, Kamidono S, Eto H, Miyake H (2005) Detection of micrometastases in pelvic lymph nodes in patients undergoing radical cystectomy for locally invasive bladder cancer by real-time reverse transcriptase-PCR for cytokeratin 19 and uroplakin II. Clin Cancer Res 11(10):3773–3777PubMedCrossRef
46.
go back to reference Morgan T, Kaffenberger S, Cookson M (2012) Surgical and chemotherapeutic management of regional lymph nodes in bladder cancer. J Urol 188:1081–1088PubMedCrossRef Morgan T, Kaffenberger S, Cookson M (2012) Surgical and chemotherapeutic management of regional lymph nodes in bladder cancer. J Urol 188:1081–1088PubMedCrossRef
47.
go back to reference May M, Herrmann E, Bolenz C, Bastian PJ et al (2011) Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy. Eur Urol 59(5):712–718PubMedCrossRef May M, Herrmann E, Bolenz C, Bastian PJ et al (2011) Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy. Eur Urol 59(5):712–718PubMedCrossRef
48.
go back to reference Stein JP, Penson DF, Cai J et al (2007) Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer. J Urol 177:876–881PubMedCrossRef Stein JP, Penson DF, Cai J et al (2007) Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer. J Urol 177:876–881PubMedCrossRef
49.
go back to reference Shariat SF, Ehdaie B, Rink M et al (2012) Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment. Eur Urol 61(2):237–242PubMedCrossRef Shariat SF, Ehdaie B, Rink M et al (2012) Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment. Eur Urol 61(2):237–242PubMedCrossRef
50.
go back to reference Koppie TM, Vickers AJ, Vora K, Dalbagni G, Bochner BH (2006) Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed? Cancer 107(10):2368–2374PubMedCrossRef Koppie TM, Vickers AJ, Vora K, Dalbagni G, Bochner BH (2006) Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed? Cancer 107(10):2368–2374PubMedCrossRef
51.
go back to reference Karakiewicz PI, Shariat SF, Palapattu GS et al (2006) Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder. J Urol 176:1354–1362PubMedCrossRef Karakiewicz PI, Shariat SF, Palapattu GS et al (2006) Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder. J Urol 176:1354–1362PubMedCrossRef
52.
go back to reference Shariat SF, Karakiewicz PI, Palapattu GS et al (2006) Nomograms provide improved accuracy for predicting survival after radical cystectomy. Clin Cancer Res 12:6663–6676PubMedCrossRef Shariat SF, Karakiewicz PI, Palapattu GS et al (2006) Nomograms provide improved accuracy for predicting survival after radical cystectomy. Clin Cancer Res 12:6663–6676PubMedCrossRef
53.
go back to reference Brossner C, Pycha A, Toth A, Mian C, Kuber W (2004) Does extended pelvic lymphadenectomy increase the morbidity of radical cystectomy? BJU Int 93:64–66PubMedCrossRef Brossner C, Pycha A, Toth A, Mian C, Kuber W (2004) Does extended pelvic lymphadenectomy increase the morbidity of radical cystectomy? BJU Int 93:64–66PubMedCrossRef
54.
go back to reference Rink M, Chun FK, Shariat SF et al (2012) Advanced bladder cancer in elderly patients. Prognostic outcomes and therapeutic strategies. Urologe A 51(6):820–828PubMedCrossRef Rink M, Chun FK, Shariat SF et al (2012) Advanced bladder cancer in elderly patients. Prognostic outcomes and therapeutic strategies. Urologe A 51(6):820–828PubMedCrossRef
55.
go back to reference Capitanio U, Suardi N, Shariat SF et al (2009) Assessing the minimum number of lymph nodes needed at radical cystectomy in patients with bladder cancer. BJU Int 103:1359–1362PubMedCrossRef Capitanio U, Suardi N, Shariat SF et al (2009) Assessing the minimum number of lymph nodes needed at radical cystectomy in patients with bladder cancer. BJU Int 103:1359–1362PubMedCrossRef
Metadata
Title
Lymph node dissection during radical cystectomy for bladder cancer treatment: considerations on relevance and extent
Authors
Lars Weisbach
Roland Dahlem
Giuseppe Simone
Jens Hansen
Armin Soave
Oliver Engel
Felix K. Chun
Shahrokh F. Shariat
Margit Fisch
Michael Rink
Publication date
01-12-2013
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 6/2013
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-013-0503-2

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