Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Surgery
Published in: BMC Surgery 1/2017

Open Access 01-12-2017 | Case report

Primary malignant melanoma of the esophagus treated with subtotal esophagectomy: a case report

Authors: Shota Kuwabara, Yuma Ebihara, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Yo Kurashima, Soichi Murakami, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano

Published in: BMC Surgery | Issue 1/2017

Login to get access

Abstract

Background

Primary malignant melanoma of the esophagus (PMME) is a rare disease with a poor prognosis. There are few reports of early-stage cases in which tumor invasion reached the lamina propria or muscularis mucosae, as in the present case. A standard treatment for early-stage PMME has not yet been established. The present study aimed to summarize previous reports and to discuss the indications for surgical treatment of early-stage primary malignant melanoma of the esophagus.

Case presentation

A 70-year-old woman with PMME was referred to our hospital. She underwent thoracoscopic and laparoscopic subtotal esophagectomy with lymphadenectomy. The resected specimen showed melanocytosis and junctional activity. Melanoma-specific antigens melan-A, S-100, and HMB45 were detected by immunohistochemical staining. The pathological diagnosis was pT1a-MM, pN0, pM0, and pStage IA. She remains alive without evidence of recurrence 39 months later.

Conclusion

Subtotal esophagectomy with regional radical lymphadenectomy could be recommended to patients with early-stage primary malignant melanoma of the esophagus, and curative surgical resection could improve their prognosis.
Literature
1.
Joob AW, Haines GK 3rd, Kies MS, Shields TW. Primary malignant melanoma of the esophagus. Ann Thorac Surg. 1995;60:217–22.CrossRefPubMed
2.
Yu H, Huang X, Li Y, et al. Primary malignant melanoma of the esophagus: a study of clinical features, pathology, management and prognosis. Dis Esophagus. 2011;24:109–13.CrossRefPubMed
3.
Sobin L, Gospodarowicz MK, Wittekind C. TMN classification of malignant Tumors, 7th ed. Hoboken: Wiley-Blackwell; 2010.
4.
Allen AC, Spitz S. Malignant melanoma; a clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer. 1953;6:1–45.CrossRefPubMed
5.
Sabanathan S, Eng J, Pradhan GN. Primary malignant of the esophagus. Am J Gastroenterol. 1989;84:1475–81.PubMed
6.
Taniyama K, Suzuki H, Sakuramachi S, Toyoda T, Matsuda M, Tahara E. Amelanotic malignant melanoma of the esophagus: case report and review of the literature. Jpn J Clin Oncol. 1990;20:286–95.PubMed
7.
8.
Yamazaki K, Ohmori T, Kumagai Y, et al. Ultrastructure of oesophageal melanocytosis. Virchows Arch A Pathol Anat Histopathol. 1991;418:515–22.CrossRefPubMed
9.
Walter A, van Rees BP, Heijnen BH, van Lanschot JJ, Offerhaus GJ. Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. Virchows Arch. 2000;437:203–7.CrossRefPubMed
10.
Iwanuma Y, Tomita N, Amano T, Isayama F, Tsurumaru M, Hayashi T, Kajiyama Y. Current status of primary malignant melanoma of the esophagus: clinical features, pathology, management and prognosis. J Gastroenterol. 2012;47:21–8.CrossRefPubMed
11.
Volpin E, Sauvanet A, Couvelard A, Belghiti J. Primary malignant melanoma of the esophagus: a case report and review of the literature. Dis Esophagus. 2002;15:244–9.CrossRefPubMed
12.
Miyatani H, Yoshida Y, Ushimaru S, Sagihara N, Yamada S. Slow growing flat-type primary malignant melanoma of the esophagus treated with cap-assisted EMR. Dig Endosc. 2009;21:255–7.CrossRefPubMed
13.
Ando N, Ozawa S, Kitajima Y. Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 2000;232:225-32.
14.
Yamaguchi T, Shioaki Y, Koide K, et al. A case of primary malignant melanoma of the esophagus and analysis of 193 patients in Japan (in Japanese). Nihon Shokakibyo Gakkai Zassi. 2004;101:1087–94.
15.
Wang S, Tachimori Y, Hokamura N, Igaki H, Kishino T, Kushima R. Diagnosis and surgical outcomes for primary malignant melanoma of the Esophagus: a single-Center experience. Ann Thorac Surg. 2013;96:1002–7.CrossRefPubMed
16.
Takahashi H, Ichikawa N, Takahashi S, Hirose K. Primary malignant of the esophagus of submucosal invasion: a case report. (in Japanese). Nihon Rinsyogeka Gakkai Zassi. 2013;74(6):1473–8.
17.
Kido T, Morishima H, Nakahara M, Nakao K, Tanimura H, Nishimura R, Tsujimoto M. Early stage primary malignant melanoma of the esophagus. Gastrointest Endosc. 2000;51(1):90–1.CrossRefPubMed
18.
Mikami T, Fukuda S, Shimoyama T, Yamagata R, Nishiya D, Sasaki Y, Uno Y, Saito H, Takaya S, Kamata Y, Munataka A. A case of early-stage primary malignant melanoma of the esophagus. Gastrointest Endosc. 2001;53(3):365–7.CrossRefPubMed
19.
Kimura H, Kato H, Sohda M, Nakajima M, Fukai Y, Miyazaki T, Masuda N, Manda R, Fukuchi M, Ojima H, Tsukada K, Kuwano H. Flat-type primary malignant melanoma of the esophagus treated by EMR: case report. Gastrointest Endosc. 2005;61(6):787–9.CrossRefPubMed
20.
Suzuki H, Nakanishi Y, Taniguchi H, Shimoda T, Yamaguchi H, Igaki H, Tachimori Y, Kato H. Two cases of early-stage esophageal malignant melanoma with long-term survival. Pathol Int. 2008;58:432–5.CrossRefPubMed
21.
Minami H, Inoue H, Satodate H, Hamatani S, Kudo S. A case of primary malignant melanoma in situ in the esophagus. Gastrointest Endosc. 2011;73(4):814–5.CrossRefPubMed
22.
Yamamoto S, Makuuchi H, Kumaki N, Ozawa S, Shimada H, Chino O, Kazuno A, Yasuda S, Tamayama T, Sakai I. A long surviving case of multiple early stage primary malignant melanoma of the esophagus and a review of the literature. Tokai J Exp Clin Med. 2015;40(3):90–5.PubMed
23.
Machado J, Ministro P, Araujo R, Cancela E, Castanheira A, Silva A. Primary malignant melanoma of the esophagus: a case report. World J Gastroenterol. 2011;17(42):4734–8.CrossRefPubMedPubMedCentral
Metadata
Title
Primary malignant melanoma of the esophagus treated with subtotal esophagectomy: a case report
Authors
Shota Kuwabara
Yuma Ebihara
Yoshitsugu Nakanishi
Toshimichi Asano
Takehiro Noji
Yo Kurashima
Soichi Murakami
Toru Nakamura
Takahiro Tsuchikawa
Keisuke Okamura
Toshiaki Shichinohe
Satoshi Hirano
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2017
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-017-0326-7

Other articles of this Issue 1/2017

BMC Surgery 1/2017 Go to the issue

Research article

Rectal-sparing type of ulcerative colitis predicts lack of response to pharmacotherapies

Research article

Intended cost reduction in laparoscopic appendectomy by introducing the endoloop: a single center experience

Research article

Transabdominal Preperitoneal (TAPP) versus Lichtenstein operation for primary inguinal hernia repair – A systematic review and meta-analysis of randomized controlled trials

Research article

Delayed gastric emptying following pancreatoduodenectomy with alimentary reconstruction according to Roux-en-Y or Billroth-II

Research article

Prognosis of ulcerative colitis colorectal cancer vs. sporadic colorectal cancer: propensity score matching analysis

Research article

Incidence of orthostatic hypotension and cardiovascular response to postoperative early mobilization in patients undergoing cardiothoracic and abdominal surgery