Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Surgery
Published in: BMC Surgery 1/2017

Open Access 01-12-2017 | Research article

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Authors: Rimantas Bausys, Augustinas Bausys, Indre Vysniauskaite, Kazimieras Maneikis, Dalius Klimas, Martynas Luksta, Kestutis Strupas, Eugenijus Stratilatovas

Published in: BMC Surgery | Issue 1/2017

Login to get access

Abstract

Background

Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania.

Methods

A total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed.

Results

Lymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results.

Conclusion

Our study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.
Literature
1.
Baušys A, Klimas D, Kilius A, Pauža K, Rudinskaite G, Samalavičius N, et al. Tumor differentiation is a risk factor for lymph node metastasis in patients with gastric cancer. Ann Oncol. 2015;26(suppl 4):iv28.
2.
Roviello F, Rossi S, Marrelli D, Pedrazzani C, Corso G, Vindigni C, et al. Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study. J Surg Oncol. 2006;94(4):275–80.CrossRefPubMed
3.
Nakahara K, Tsuruta O, Tateishi H, Arima N, Takeda J, Toyonaga A, et al. Extended indication criteria for endoscopic mucosal resection of early gastric cancer with special reference to lymph node metastasis-- examination by multivariate analysis. Kurume Med J. 2004;51(1):9–14.CrossRefPubMed
4.
Hopkins S, Yang GY. FDG PET imaging in the staging and management of gastric cancer. J Gastrointest Oncol. 2011;2(1):39–44.PubMedPubMedCentral
5.
Hallinan JTPD, Venkatesh SK. Gastric carcinoma: imaging diagnosis, staging and assessment of treatment response. Cancer Imaging Off Publ Int Cancer Imaging Soc. 2013;13:212–27.
6.
Hasbahceci M, Akcakaya A, Memmi N, Turkmen I, Cipe G, Yildiz P, et al. Diffusion MRI on lymph node staging of gastric adenocarcinoma. Quant Imaging Med Surg. 2015;5(3):392–400.PubMedPubMedCentral
7.
Soetikno R, Kaltenbach T, Yeh R, Gotoda T. Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract. J Clin Oncol Off J Am Soc Clin Oncol. 2005;23(20):4490–8.CrossRef
8.
Gotoda T. Endoscopic resection of early gastric cancer. Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2007;10(1):1–11.
9.
Gotoda T, Yanagisawa A, Sasako M, Ono H, Nakanishi Y, Shimoda T, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2000;3(4):219–25.
10.
Yamaguchi N, Isomoto H, Fukuda E, Ikeda K, Nishiyama H, Akiyama M, et al. Clinical outcomes of endoscopic submucosal dissection for early gastric cancer by indication criteria. Digestion. 2009;80(3):173–81.CrossRefPubMed
11.
Fukuhara S, Yabe M, Montgomery MM, Itagaki S, Brower ST, Karpeh MS. Race/ethnicity is predictive of lymph node status in patients with early gastric cancer. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2014;18(10):1744–51.CrossRef
12.
Ikoma N, Blum M, Chiang Y-J, Estrella JS, Roy-Chowdhuri S, Fournier K, et al. Race is a risk for lymph node metastasis in patients with gastric cancer. Ann Surg Oncol. 2017;24(4):960–5.CrossRefPubMed
13.
Suzuki H, Oda I, Abe S, Sekiguchi M, Nonaka S, Yoshinaga S, et al. Clinical outcomes of early gastric cancer patients after noncurative endoscopic submucosal dissection in a large consecutive patient series. Gastric Cancer. 2016. [Epub ahead of print].
14.
Lim MS, Lee H-W, Im H, Kim BS, Lee MY, Jeon JY, et al. Predictable factors for lymph node metastasis in early gastric cancer-analysis of single institutional experience. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2011;15(10):1783–8.CrossRef
15.
Zhao L-Y, Yin Y, Li X, Zhu C-J, Wang Y-G, Chen X-L, et al. A nomogram composed of clinicopathologic features and preoperative serum tumor markers to predict lymph node metastasis in early gastric cancer patients. Oncotarget. 2016;7(37):59630-39.
16.
17.
Zheng Z, Zhang Y, Zhang L, Li Z, Wu X, Liu Y, et al. A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients. BMC Cancer. 2015;16:92.CrossRef
18.
Ahmad R, Setia N, Schmidt BH, Hong TS, Wo JY, Kwak EL, et al. Predictors of lymph node metastasis in western early gastric cancer. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2016;20(3):531–8.CrossRef
19.
Sekiguchi M, Oda I, Taniguchi H, Suzuki H, Morita S, Fukagawa T, et al. Risk stratification and predictive risk-scoring model for lymph node metastasis in early gastric cancer. J Gastroenterol. 2016;51(10):961–70.CrossRefPubMed
20.
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, et al. Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan. J Gastroenterol. 2017;52(2):175–84.CrossRefPubMed
21.
Nakamura Y, Yasuoka H, Tsujimoto M, et al. Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. J Clin Pathol. 2006;59:77–82.CrossRefPubMedPubMedCentral
22.
Haist T, Pritzer H, Pauthner M, Fisseler-Eckhoff A, Lorenz D. Prognostic risk factors of early gastric cancer-a western experience. Langenbecks Arch Surg Dtsch Ges Für Chir. 2016;401(5):667–76.CrossRef
23.
Bravo Neto GP, dos Santos EG, Victer FC, Carvalho CE de S. Lymph node metastasis in early gastric cancer. Rev Colégio Bras Cir 2014; 41(1):11–7.
24.
Ronellenfitsch U, Lippert C, Grobholz R, Lang S, Post S, Kähler G, et al. Histology-based prediction of lymph node metastases in early gastric cancer as decision guidance for endoscopic resection. Oncotarget. 2016;7(9):10676–83.CrossRefPubMedPubMedCentral
25.
Ren G, Cai R, Zhang W-J, Ou J-M, Jin Y-N, Li W-H. Prediction of risk factors for lymph node metastasis in early gastric cancer. World J Gastroenterol. 2013;19(20):3096–107.CrossRefPubMedPubMedCentral
26.
Wang L, Liang H, Wang X, Wu L, Ding X, Liu H. Mode of lymph node metastasis in early gastric cancer and risk factors. Zhonghua Wei Chang Wai Ke Za Zhi Chin J Gastrointest Surg. 2013;16(2):147–50.
27.
Nakagawa M, Choi YY, An JY, Chung H, Seo SH, Shin HB, et al. Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study. BMC Cancer. 2015;15:943.CrossRefPubMedPubMedCentral
28.
Park JH, Lee SH, Park JM, Park CS, Park KS, Kim ES, et al. Prediction of the indication criteria for endoscopic resection of early gastric cancer. World J Gastroenterol. 2015;21(39):11160–7.CrossRefPubMedPubMedCentral
29.
Fang W-L, Huang K-H, Lan Y-T, Chen M-H, Chao Y, Lo S-S, et al. The risk factors of lymph node metastasis in early gastric cancer. Pathol Oncol Res POR. 2015;21(4):941–6.CrossRefPubMed
30.
Wang Y-W, Zhu M-L, Wang R-F, Xue W-J, Zhu X-R, Wang L-F, et al. Predictable factors for lymph node metastasis in early gastric cancer analysis of clinicopathologic factors and biological markers. Tumour Biol J Int Soc Oncodevelopmental Biol Med. 2016;37(7):8567–78.CrossRef
31.
Milhomem LM, Cardoso DMM, Mota ED, Fraga-Júnior AC, Martins E, da Mota OM. Frequency and predictive factors related to lymphatic metastasis in early gastric cancer. Arq Bras Cir Dig ABCD Braz Arch Dig Surg. 2012;25(4):235–9.CrossRef
Metadata
Title
Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania
Authors
Rimantas Bausys
Augustinas Bausys
Indre Vysniauskaite
Kazimieras Maneikis
Dalius Klimas
Martynas Luksta
Kestutis Strupas
Eugenijus Stratilatovas
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2017
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-017-0304-0

Other articles of this Issue 1/2017

BMC Surgery 1/2017 Go to the issue

Research article

Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma

Research article

Posterior intervertebral space debridement, annular bone grafting and instrumentation for treatment of lumbosacral tuberculosis

Case report

Martius’ flap for recurrent perineal and rectovaginal fistulae in a patient with Crohn’s disease, endometriosis and a mullerian anomaly

Research article

Prevention of hypothermia in patients undergoing orthotopic liver transplantation using the humigard® open surgery humidification system: a prospective randomized pilot and feasibility clinical trial

Case report

Successful access to the ampulla for endoscopic retrograde cholangiopancreatography in patients with situs inversus totalis: a case report

Research article

Contributing factors of elective surgical case cancellation: a retrospective cross-sectional study at a single-site hospital