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BMC Musculoskeletal Disorders

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Open Access 01-12-2019 | Dexamethasone | Research article

Relationship between the changes over time of bone mass and muscle health in children and adults: a systematic review and meta-analysis

Authors: Médéa Locquet, Charlotte Beaudart, Nancy Durieux, Jean-Yves Reginster, Olivier Bruyère

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

Abstract

Background

Various cross-sectional studies provide an abundance of evidence that shows a relationship between bone quantity and muscle health. However, one question remains, less-often studied: is their development - or decline – associated? The aim of the research was to conduct a systematic review and meta-analysis to summarize the studies exploring the association between changes in bone mineral density (BMD) and changes in muscle parameters (registration CRD42018093813).

Methods

We searched for prospective studies, both in children and adults, by consulting electronic databases (Ovid-MEDLINE, Ovid-AMED, Scopus). Each review steps were performed by two independent reviewers. For outcomes reported by less of 3 studies, we synthetized the results narratively. In other cases, a meta-analysis was performed, giving an overall r coefficient and its 95% confidence interval (CI).

Results

Fifteen papers were included. In connection with the change of BMD, 10 studies concerned the parallel change of lean mass, 4 were about grip strength, and 1 was about physical performance. Children were the population of interest for 5 studies, while the aging population was the focus of the other studies. The correlation between hip BMD and lean mass was significant, with an overall coefficient r = 0.37 (95% CI 0.23–0.49). High heterogeneity was observed between studies but the length of follow-up, sex and study quality did not seem to significantly influence results. The systematic review allowed some other highlights: a significant link between changes in BMD and changes in muscle strength was observed (p-value < 0.05 in the 4 studies), in addition to changes in performance (1 study, r = 0.21, p-value = 0.004).

Conclusion

Despite the heterogeneity between studies, we highlighted a significant association between the change of BMD and the change of various muscle parameters. Future studies should investigate preventive and therapeutic strategies that are based on a single entity: the ‘muscle-bone unit’.

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Title: Relationship between the changes over time of bone mass and muscle health in children and adults: a systematic review and meta-analysis
Authors: Médéa Locquet
Charlotte Beaudart
Nancy Durieux
Jean-Yves Reginster
Olivier Bruyère
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Dexamethasone
Published in: BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-019-2752-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between the changes over time of bone mass and muscle health in children and adults: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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