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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2019

Open Access 01-12-2019 | Shoulder Instability | Study protocol

Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study

Authors: Richard S. Page, Sean L. McGee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier, Stephen D. Gill

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

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Abstract

Background

Adhesive capsulitis (AC) is a disabling and poorly understood pathological condition of the shoulder joint. The current study aims to increase our understanding of the pathogenesis, diagnosis and clinical outcomes of people with AC by investigating: 1) transcriptome-wide alterations in gene expression of the glenohumeral joint capsule in people with AC compared to people with non-inflammatory shoulder instability (controls); 2) serum and urine biomarkers to better understand diagnosis and staging of AC; and 3) clinical outcomes in people with AC compared to controls 12-months following arthroscopic capsular release or labral repair respectively.

Methods

The study is a prospective multi-centre longitudinal study investigating people undergoing arthroscopic capsulotomy for AC compared to people undergoing arthroscopic stabilization for shoulder instability. Tissue samples collected from the anterior glenohumeral joint capsule during surgery will undergo RNA-seq to determine differences in gene expression between the study groups. Gene Set Enrichment Analysis will be used to further understand the pathogenesis of AC as well as guide serum and urine biomarker analysis. Clinical outcomes regarding pain, function and quality of life will be assessed using the Oxford Shoulder Score, Oxford Shoulder Instability Score, Quick DASH, American Shoulder and Elbow Society Score, EQ-5D-5 L and active shoulder range of movement. Clinical outcomes will be collected pre-operatively and 12-months post-operatively and study groups will be compared for statistically significant differences using linear regression, adjusting for baseline demographic variables.

Discussion

This study will provide much needed information regarding the pathogenesis, diagnosis and staging of AC. It will evaluate clinical outcomes for people undergoing arthroscopic release of AC by comparing this group to people undergoing arthroscopic surgery for shoulder instability.

Trial registration

ACTRN12618000431​224, retrospectively registered 26 March 2018.
Literature
1.
Le HV, Lee SJ, Nazarian A, Rodriguez EK. Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. 2017;9(2):75–84.CrossRef
2.
Codman E. The shoulder: rupture of the supraspinatus tendon and other lesions in or about the subacromial bursa. Boston: Thomas Todd; 1934.
3.
Buchbinder R, Green S, Youd JM, Johnston RV, Cumpston M: Arthrographic distension for adhesive capsulitis (frozen shoulder). Cochrane Database Syst Rev 2008(1):CD007005.
4.
Page RS, Mitreski G. The stiff shoulder. In: Trail IA, Funk L, Rangan A, Gewerbestrasse NM, editors. Textbook of Shoulder Surgery. 1st edn. Switzerland: Springer International Publishing; 2019.
5.
Hsu JE, Anakwenze OA, Warrender WJ, Abboud JA. Current review of adhesive capsulitis. J Shoulder Elb Surg. 2011;20(3):502–14.CrossRef
6.
Wong CK, Levine WN, Deo K, Kesting RS, Mercer EA, Schram GA, Strang BL. Natural history of frozen shoulder: fact or fiction? A systematic review. Physiotherapy. 2017;103(1):40–7.CrossRef
7.
Hand C, Clipsham K, Rees JL, Carr AJ. Long-term outcome of frozen shoulder. J Shoulder Elb Surg. 2008;17(2):231–6.CrossRef
8.
Zuckerman JD, Rokito A. Frozen shoulder: a consensus definition. J Shoulder Elb Surg. 2011;20(2):322–5.CrossRef
9.
Walmsley S, Osmotherly PG, Rivett DA. Clinical identifiers for early-stage primary/idiopathic adhesive capsulitis: are we seeing the real picture? Phys Ther. 2014;94(7):968–76.CrossRef
10.
11.
Boyle-Walker KL, Gabard DL, Bietsch E, Masek-VanArsdale DM, Robinson BL. A profile of patients with adhesive capsulitis. J Hand Ther. 1997;10(3):222–8.CrossRef
12.
Bunker T. Time for a new name for frozen shoulder - contracture of the shoulder. Shoulder & Elbow. 2009;1(1):4–9.CrossRef
13.
Hanchard NC, Goodchild L, Thompson J, O'Brien T, Davison D, Richardson C. A questionnaire survey of UK physiotherapists on the diagnosis and management of contracted (frozen) shoulder. Physiotherapy. 2011;97(2):115–25.CrossRef
14.
Harris G, Bou-Haidar P, Harris C. Adhesive capsulitis: review of imaging and treatment. J Med Imaging Radiat Oncol. 2013;57(6):633–43.CrossRef
15.
Lho YM, Ha E, Cho CH, Song KS, Min BW, Bae KC, Lee KJ, Hwang I, Park HB. Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder. J Shoulder Elb Surg. 2013;22(5):666–72.CrossRef
16.
Rodeo SA, Hannafin JA, Tom J, Warren RF, Wickiewicz TL. Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder. J Orthop Res. 1997;15(3):427–36.CrossRef
17.
Kabbabe B, Ramkumar S, Richardson M. Cytogenetic analysis of the pathology of frozen shoulder. Int J Shoulder Surg. 2010;4(3):75–8.CrossRef
18.
Robinson CM, Seah KT, Chee YH, Hindle P, Murray IR. Frozen shoulder. J Bone Joint Surg Br. 2012;94(1):1–9.CrossRef
19.
Hettrich CM, DiCarlo EF, Faryniarz D, Vadasdi KB, Williams R, Hannafin JA. The effect of myofibroblasts and corticosteroid injections in adhesive capsulitis. J Shoulder Elb Surg. 2016;25(8):1274–9.CrossRef
20.
Bunker TD, Anthony PP. The pathology of frozen shoulder. A Dupuytren-like disease. J Bone Joint Surg Br. 1995;77(5):677–83.CrossRef
21.
Hagiwara Y, Ando A, Onoda Y, Takemura T, Minowa T, Hanagata N, Tsuchiya M, Watanabe T, Chimoto E, Suda H, et al. Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders. Osteoarthr Cartil. 2012;20(3):241–9.CrossRef
22.
Prodromidis AD, Charalambous CP. Is there a genetic predisposition to frozen shoulder?: a systematic review and meta-analysis. JBJS Rev. 2016;4(2).CrossRef
23.
Arkkila PE, Kantola IM, Viikari JS, Rönnemaa T. Shoulder capsulitis in type I and II diabetic patients: association with diabetic complications and related diseases. Ann Rheum Dis. 1996;55(12):907–14.CrossRef
24.
Cui J, Zhang T, Xiong J, Lu W, Duan L, Zhu W, Wang D. RNA-sequence analysis of samples from patients with idiopathic adhesive capsulitis. Mol Med Rep. 2017;16(5):7665–72.CrossRef
25.
Cher JZB, Akbar M, Kitson S, Crowe LAN, Garcia-Melchor E, Hannah SC, McLean M, Fazzi UG, Kerr SC, Murrell GAC, et al. Alarmins in frozen shoulder: a molecular association between inflammation and pain. Am J Sports Med. 2018;46(3):671–8.CrossRef
26.
Cher JZB, Akbar M, Kitson S, Crowe LAN, Garcia-Melchor E, Hannah SC, McLean M, Fazzi UG, Kerr SC, Murrell GAC et al: Alarmins in frozen shoulder: a molecular association between inflammation and pain. Am J Sports Med 2017:363546517741127.
27.
Bonacci J, Manson B, Bowe SJ, Gill S, Seward H, Hoy G, Page R. Operative shoulder instability injury management in Australian football league players: a case series. J Sci Med Sport. 2017.
28.
Pearce H, Page RS, Soeding PF, Hoy G. Guidelines for shoulder surgery in the beach chair position. In: Shoulder and Elbow Society of Australia, Biennial Scientific Meeting. Melbourne; 2014.
29.
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15–21.CrossRef
30.
Petersen TN, Brunak S, von Heijne G, Nielsen H. SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods. 2011;8(10):785–6.CrossRef
31.
Bendtsen JD, Jensen LJ, Blom N, Von Heijne G, Brunak S. Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel. 2004;17(4):349–56.CrossRef
32.
Dawson J, Rogers K, Fitzpatrick R, Carr A. The Oxford shoulder score revisited. Arch Orthop Trauma Surg. 2009;129(1):119–23.CrossRef
33.
Dawson J, Fitzpatrick R, Carr A. The assessment of shoulder instability The development and validation of a questionnaire. J Bone Joint Surg Br. 1999;81(3):420–6.CrossRef
34.
Beaton DE, Wright JG, Katz JN, Group UEC. Development of the QuickDASH comparison of three item reduction approaches. J Bone Joint Surg Am. 2005;87:1038–46.PubMed
35.
Michener L, McClure P, Sennett B. American shoulder and elbow surgeons standardized shoulder assessment form, patient self-report section: reliability, validity, and responsiveness. J Shoulder Elb Surg. 2002;11(6):587–94.CrossRef
36.
Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, Bonsel G, Badia X. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011;20(10):1727–36.CrossRef
37.
Page RS, Beattie S, Williams S, Gill SD. Clinical quality registries: local registries complement national registries. An example from joint arthroplasty. ANZ J Surg. 2018;88(7–8):667–8.CrossRef
38.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.CrossRef
39.
National Statement on Ethical Conduct in Human Research 2007 (Updated May 2015). The National Health and Medical Research Council, the Australian Research Council and the Australian Vice-Chancellors’ Committee. Commonwealth of Australia, Canberra.
Metadata
Title
Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study
Authors
Richard S. Page
Sean L. McGee
Kevin Eng
Graeme Brown
Sally Beattie
Fiona Collier
Stephen D. Gill
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-019-2536-x

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