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BMC Musculoskeletal Disorders

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Open Access 01-12-2019 | Bisphosphonate | Case report

SAPHO syndrome with pathological fractures of vertebral bodies: a case report

Authors: Yalong Li, Guomin Liu, Yian Zhao, Yungang Luo, Tiancheng Lu

Published in: BMC Musculoskeletal Disorders | Issue 1/2019

Abstract

Background

It’s difficult to diagnose and treat synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome due to its rare and unknown pathogenesis. There is no effective treatment for SAPHO syndrome and the consequences of empirical treatment are unpredictable. This study reports a case of a young female diagnosed as SAPHO syndrome with pathological fractures of vertebral bodies.

Case presentation

A 29-year-old female complained of the right sternoclavicular joint and back pain accompanied limited activities and cutaneous lesions. Laboratory assays revealed abnormal inflammatory factors. Multiple imaging studies illustrated bone lesions and pathological fractures of vertebral bodies. A diagnosis of SAPHO syndrome was made. The patient was treated with Compound Troxerutin and Poreine Cerebroside Injection, non-steroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, corticosteroids and the thoracolumbar brace. The patient was followed up for 6 months and showed improved results.

Conclusions

The case supports that multiple image inspections and laboratory tests contribute to diagnose SAPHO syndrome, and combination therapies of Compound Troxerutin and Poreine Cerebroside Injection, NSAIDs, bisphosphonates, corticosteroids and the thoracolumbar brace in the treatment of SAPHO syndrome with pathological fractures of vertebral bodies are crucial to regain health.

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Title: SAPHO syndrome with pathological fractures of vertebral bodies: a case report
Authors: Yalong Li
Guomin Liu
Yian Zhao
Yungang Luo
Tiancheng Lu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Bisphosphonate
Acne
Osteitis
Osteomyelitis
Published in: BMC Musculoskeletal Disorders / Issue 1/2019
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-019-2410-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

SAPHO syndrome with pathological fractures of vertebral bodies: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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