Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2017

Open Access 01-12-2017 | Review

Magnetic resonance imaging of bacterial and tuberculous spondylodiscitis with associated complications and non-infectious spinal pathology mimicking infections: a pictorial review

Authors: Yogesh Kumar, Nishant Gupta, Avneesh Chhabra, Takeshi Fukuda, Neetu Soni, Daichi Hayashi

Published in: BMC Musculoskeletal Disorders | Issue 1/2017

Login to get access

Abstract

Magnetic resonance (MR) imaging plays an important role in the evaluation of bacterial and tuberculous spondylodiscitis and associated complications. Owing to its high sensitivity and specificity, it is a powerful diagnostic tool in the early diagnosis of ongoing infections, and thus provides help in prompt initiation of appropriate, therapy which may be medical or surgical, by defining the extent of involvement and detection of complications such as epidural and paraspinal abscesses. More specifically, MR imaging helps in differentiating bacterial from tuberculous infections and enables follow up of progression or resolution after appropriate treatment. However, other non-infectious pathology can demonstrate similar MR imaging appearances and one should be aware of these potential mimickers when interpreting MR images. Radiologists and other clinicians need to be aware of these potential mimics, which include such pathologies as Modic type I degenerative changes, trauma, metastatic disease and amyloidosis. In this pictorial review, we will describe and illustrate imaging findings of bacterial and tuberculous spondylodiscitis, their complications and non-infectious pathologies that mimic these spinal infections.
Literature
2.
go back to reference Kourbeti IS, Tsiodras S, Boumpas DT. Spinal infections: evolving concepts. Curr Opin Rheumatol. 2008;20:471–9.CrossRefPubMed Kourbeti IS, Tsiodras S, Boumpas DT. Spinal infections: evolving concepts. Curr Opin Rheumatol. 2008;20:471–9.CrossRefPubMed
3.
go back to reference Tins BJ, Cassar-Pullicino VN. MR imaging of spinal infection. Semin Musculoskelet Radiol. 2004;8:215–29.CrossRefPubMed Tins BJ, Cassar-Pullicino VN. MR imaging of spinal infection. Semin Musculoskelet Radiol. 2004;8:215–29.CrossRefPubMed
4.
go back to reference Galhotra RD, Jain T, Sandhu P, Galhotra V. Utility of magnetic resonance imaging in the differential diagnosis of tubercular and pyogenic spondylodiscitis. J Nat Sci Biol Med. 2015;6:388–93.CrossRefPubMedPubMedCentral Galhotra RD, Jain T, Sandhu P, Galhotra V. Utility of magnetic resonance imaging in the differential diagnosis of tubercular and pyogenic spondylodiscitis. J Nat Sci Biol Med. 2015;6:388–93.CrossRefPubMedPubMedCentral
5.
go back to reference Ledbetter LN, Salzman KL, Shah LM. Imaging psoas sign in lumbar spinal infections: evaluation of diagnostic accuracy and comparison with established imaging characteristics. AJNR Am J Neuroradiol. 2016;37:736–41.CrossRefPubMed Ledbetter LN, Salzman KL, Shah LM. Imaging psoas sign in lumbar spinal infections: evaluation of diagnostic accuracy and comparison with established imaging characteristics. AJNR Am J Neuroradiol. 2016;37:736–41.CrossRefPubMed
7.
go back to reference Adams A, Roche O, Mazumder A, Davagnanam I, Mankad K. Imaging of degenerative lumbar intervertebral discs; linking anatomy, pathology and imaging. Postgrad Med J. 2014;90:511–9.CrossRefPubMed Adams A, Roche O, Mazumder A, Davagnanam I, Mankad K. Imaging of degenerative lumbar intervertebral discs; linking anatomy, pathology and imaging. Postgrad Med J. 2014;90:511–9.CrossRefPubMed
8.
go back to reference Stabler A, Bellan M, Weiss M, Gartner C, Brossmann J, Reiser MF. MR imaging of enhancing intraosseous disk herniation (Schmorl’s nodes). AJR Am J Roentgenol. 1997;168:933–8.CrossRefPubMed Stabler A, Bellan M, Weiss M, Gartner C, Brossmann J, Reiser MF. MR imaging of enhancing intraosseous disk herniation (Schmorl’s nodes). AJR Am J Roentgenol. 1997;168:933–8.CrossRefPubMed
9.
go back to reference Shih TT, Chen PQ, Li YW, Hsu CY. Spinal fractures and pseudoarthrosis complicating ankylosing spondylitis: MRI manifestation and clinical significance. J Comput Assist Tomogr. 2001;25:164–70.CrossRefPubMed Shih TT, Chen PQ, Li YW, Hsu CY. Spinal fractures and pseudoarthrosis complicating ankylosing spondylitis: MRI manifestation and clinical significance. J Comput Assist Tomogr. 2001;25:164–70.CrossRefPubMed
10.
go back to reference Lacout A, Lebreton C, Mompoint D, Mokhtari S, Vallee CA, Carlier RY. CT and MRI of spinal neuroarthropathy. AJR Am J Roentgenol. 2009;193:W505–14.CrossRefPubMed Lacout A, Lebreton C, Mompoint D, Mokhtari S, Vallee CA, Carlier RY. CT and MRI of spinal neuroarthropathy. AJR Am J Roentgenol. 2009;193:W505–14.CrossRefPubMed
11.
go back to reference Artenstein AW, Friderici J, Holers A, Lewis D, Fitzgerald J, Visintainer P. Spinal epidural abscess in adults: a 10-year clinical experience at a tertiary care academic medical center. Open Forum Infect Dis. 2016;3:ofw191.CrossRefPubMedPubMedCentral Artenstein AW, Friderici J, Holers A, Lewis D, Fitzgerald J, Visintainer P. Spinal epidural abscess in adults: a 10-year clinical experience at a tertiary care academic medical center. Open Forum Infect Dis. 2016;3:ofw191.CrossRefPubMedPubMedCentral
12.
go back to reference Patel A, Alton T, Bransford R, et al. Spinal epidural abscesses: risk factors, medical versus surgical management, a retrospective review of 128 cases. Spine J. 2014;14:326–30.CrossRefPubMed Patel A, Alton T, Bransford R, et al. Spinal epidural abscesses: risk factors, medical versus surgical management, a retrospective review of 128 cases. Spine J. 2014;14:326–30.CrossRefPubMed
13.
go back to reference Stratton A, Gustafson K, Thomas K, James MT. Incidence and risk factors for failed medical management of spinal epidural abscess: a systematic review and meta-analysis. J Neurosurg Spine. 2017;26:81–9.CrossRefPubMed Stratton A, Gustafson K, Thomas K, James MT. Incidence and risk factors for failed medical management of spinal epidural abscess: a systematic review and meta-analysis. J Neurosurg Spine. 2017;26:81–9.CrossRefPubMed
14.
go back to reference Alonge TO, Ogunlade SO, Omololu AB, Obajimi M. Infective lumbar discitis in a sickler–an occult 'typhoid' spine? West Afr J Med. 2003;22:267–8. Alonge TO, Ogunlade SO, Omololu AB, Obajimi M. Infective lumbar discitis in a sickler–an occult 'typhoid' spine? West Afr J Med. 2003;22:267–8.
15.
go back to reference Sehn JK, Gilula LA. Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis. Eur J Radiol. 2012;81:940–6.CrossRefPubMed Sehn JK, Gilula LA. Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis. Eur J Radiol. 2012;81:940–6.CrossRefPubMed
17.
go back to reference Sharma A, Chhabra HS, Mahajan R, Chabra T, Batra S. Magnetic resonance imaging and GeneXpert: a rapid and accurate diagnostic tool for the management of tuberculosis of the spine. Asian Spine J. 2016;10:850–6.CrossRefPubMedPubMedCentral Sharma A, Chhabra HS, Mahajan R, Chabra T, Batra S. Magnetic resonance imaging and GeneXpert: a rapid and accurate diagnostic tool for the management of tuberculosis of the spine. Asian Spine J. 2016;10:850–6.CrossRefPubMedPubMedCentral
18.
go back to reference De la Garza RR, Goodwin CR, Abu-Bonsrah N, Bydon A, Witham TF, Wolinsky JP, et al. The epidemiology of spinal tuberculosis in the United States: an analysis of 2002-2011 data. J Neurosurg Spine. 2017;26:507–12.CrossRef De la Garza RR, Goodwin CR, Abu-Bonsrah N, Bydon A, Witham TF, Wolinsky JP, et al. The epidemiology of spinal tuberculosis in the United States: an analysis of 2002-2011 data. J Neurosurg Spine. 2017;26:507–12.CrossRef
20.
go back to reference Ratcliffe JF. The arterial anatomy of the adult human lumbar vertebral body: a microarteriographic study. J Anat. 1980;131(Pt1):57–79.PubMedPubMedCentral Ratcliffe JF. The arterial anatomy of the adult human lumbar vertebral body: a microarteriographic study. J Anat. 1980;131(Pt1):57–79.PubMedPubMedCentral
21.
go back to reference Moritani T, Kim J, Capizzano AA, Kirby P, Kademian J, Sato Y. Pyogenic and non-pyogenic spinal infections: emphasis on diffusion-weighted imaging for the detection of abscesses and pus collections. Br J Radiol. 2014;87:20140011.CrossRefPubMedPubMedCentral Moritani T, Kim J, Capizzano AA, Kirby P, Kademian J, Sato Y. Pyogenic and non-pyogenic spinal infections: emphasis on diffusion-weighted imaging for the detection of abscesses and pus collections. Br J Radiol. 2014;87:20140011.CrossRefPubMedPubMedCentral
22.
go back to reference Sundaram VK, Doshi A. Infections of the spine: a review of clinical and imaging findings. Appl Radiol. 2016;45:10–20. Sundaram VK, Doshi A. Infections of the spine: a review of clinical and imaging findings. Appl Radiol. 2016;45:10–20.
23.
go back to reference Ansari S, Amanullah MF, Ahmad K, Rauniyar RK. Pott’s spine: diagnostic imaging modalities and technology advancements. N Am J Med Sci. 2013;5:404–11.CrossRefPubMedPubMedCentral Ansari S, Amanullah MF, Ahmad K, Rauniyar RK. Pott’s spine: diagnostic imaging modalities and technology advancements. N Am J Med Sci. 2013;5:404–11.CrossRefPubMedPubMedCentral
24.
go back to reference Wu JS, Gorbachova T, Morrison WB, Haims AH. Imaging-guided bone biopsy for osteomyeltitis: are there factors associated with positive and negative cultures? Am J Roentgenol. 2007;188:1529–34.CrossRef Wu JS, Gorbachova T, Morrison WB, Haims AH. Imaging-guided bone biopsy for osteomyeltitis: are there factors associated with positive and negative cultures? Am J Roentgenol. 2007;188:1529–34.CrossRef
25.
go back to reference Mahnken AH, Wildberger JE, Adam G, Stanzel S, Schmitz-Rode T, Gunther RW, et al. Is there a need for contrast-enhanced T1-weighted MRI of the spine after inconspicuous short tau inversion recovery imaging? Eur Radiol. 2005;15:1387–92.CrossRefPubMed Mahnken AH, Wildberger JE, Adam G, Stanzel S, Schmitz-Rode T, Gunther RW, et al. Is there a need for contrast-enhanced T1-weighted MRI of the spine after inconspicuous short tau inversion recovery imaging? Eur Radiol. 2005;15:1387–92.CrossRefPubMed
26.
go back to reference Kumar Y, Wadhwa V, Phillips L, Pezeshk P, Chhabra A. MR imaging of skeletal muscle signal alterations: systematic approach to evaluation. Eur J Radiol. 2016;85:922–35.CrossRefPubMed Kumar Y, Wadhwa V, Phillips L, Pezeshk P, Chhabra A. MR imaging of skeletal muscle signal alterations: systematic approach to evaluation. Eur J Radiol. 2016;85:922–35.CrossRefPubMed
27.
go back to reference Castillo M. Diffusion-weighted imaging of the spine: is it reliable? AJNR Am J Neuroradiol. 2003;24:1251–3.PubMed Castillo M. Diffusion-weighted imaging of the spine: is it reliable? AJNR Am J Neuroradiol. 2003;24:1251–3.PubMed
28.
go back to reference Raya JG, Dietrich O, Birkenmaier C, Sommer J, Reiser MF, Baur-Melnyk A. Feasibility of a RARE-based sequence for quantitative diffusion-weighted MRI of the spine. Eur Radiol. 2007;17:2872–9.CrossRefPubMed Raya JG, Dietrich O, Birkenmaier C, Sommer J, Reiser MF, Baur-Melnyk A. Feasibility of a RARE-based sequence for quantitative diffusion-weighted MRI of the spine. Eur Radiol. 2007;17:2872–9.CrossRefPubMed
29.
go back to reference Kumar Y, Khaleel M, Boothe E, Awdeh H, Wadhwa V, Chhabra A. Role of diffusion weighted imaging in musculoskeletal infections: current perspectives. Eur Radiol. 2017;27:414–23.CrossRefPubMed Kumar Y, Khaleel M, Boothe E, Awdeh H, Wadhwa V, Chhabra A. Role of diffusion weighted imaging in musculoskeletal infections: current perspectives. Eur Radiol. 2017;27:414–23.CrossRefPubMed
30.
go back to reference Glaziou P, Falzon D, Floyd K, Raviglione M. Global epidemiology of tuberculosis. Semin Respir Crit Care Med. 2013;34:3–16.CrossRefPubMed Glaziou P, Falzon D, Floyd K, Raviglione M. Global epidemiology of tuberculosis. Semin Respir Crit Care Med. 2013;34:3–16.CrossRefPubMed
31.
go back to reference Alvi AA, Raees A, Khan Rehmani MA, Aslam HM, Saleem S, Ashraf J. Magnetic resonance image findings of spinal tuberculosis at first presentation. Int Arch Med. 2014;7:12.CrossRefPubMedPubMedCentral Alvi AA, Raees A, Khan Rehmani MA, Aslam HM, Saleem S, Ashraf J. Magnetic resonance image findings of spinal tuberculosis at first presentation. Int Arch Med. 2014;7:12.CrossRefPubMedPubMedCentral
33.
go back to reference Theodorou DJ, Theodorou SJ, Resnick D. Imaging in dialysis spondyloarthropathy. Semin Dial. 2002;15:290–6.CrossRefPubMed Theodorou DJ, Theodorou SJ, Resnick D. Imaging in dialysis spondyloarthropathy. Semin Dial. 2002;15:290–6.CrossRefPubMed
Metadata
Title
Magnetic resonance imaging of bacterial and tuberculous spondylodiscitis with associated complications and non-infectious spinal pathology mimicking infections: a pictorial review
Authors
Yogesh Kumar
Nishant Gupta
Avneesh Chhabra
Takeshi Fukuda
Neetu Soni
Daichi Hayashi
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2017
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-017-1608-z

Other articles of this Issue 1/2017

BMC Musculoskeletal Disorders 1/2017 Go to the issue