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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2016

Open Access 01-12-2016 | Research article

Autologous bone graft in the treatment of post-traumatic bone defects: a systematic review and meta-analysis

Authors: Matheus Lemos Azi, Alessandro Aprato, Irene Santi, Mauricio Kfuri Jr, Alessandro Masse, Alexander Joeris

Published in: BMC Musculoskeletal Disorders | Issue 1/2016

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Abstract

Background

This meta-analysis aimed to determine the bone union rate of bone defects treated with the different autologous bone graft techniques.

Methods

The PubMed and the Cochrane Library databases were searched using the terms: ‘fracture’ AND (‘bone loss’ OR ‘defect’ OR ‘defects’) AND ‘bone graft’, restricted to English language, to human species, and to a publication period from January 1999 to November 2014. Data were extracted by one of the reviewers and then checked by the second. A quality of evidence score and a methodology score were used. Heterogeneity was assessed. A random effects model approach was used to combine estimates.

Results

Out of 376 selected studies only 34 met the inclusion criteria. The summary pooled union rate was 91 % (95 % CI: 87–95 %) while union rate after additional procedures raised to 98 % (95 % CI 96–99 %). No association between union rate and bone defect size was found. (Univariable regression model: vascularized: P = 0.677; non-vascularized: 0.202. Multivariable regression model: vascularized: P = 0.381; non-vascularized: P = 0.226). Vascularized graft was associated with a lower risk of infection after surgery when compared to non-vascularized graft (95 % CI 0.03 to 0.23, p < 0.001).

Conclusion

The results of this meta-analysis demonstrate the effectiveness of autologous graft for bone defects. Furthermore, from the available clinical evidence bone defect size does not seem to have an impact on bone union when treated with autologous bone graft techniques.
Appendix
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Metadata
Title
Autologous bone graft in the treatment of post-traumatic bone defects: a systematic review and meta-analysis
Authors
Matheus Lemos Azi
Alessandro Aprato
Irene Santi
Mauricio Kfuri Jr
Alessandro Masse
Alexander Joeris
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2016
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-016-1312-4

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