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Published in: BMC Pulmonary Medicine 1/2021

Open Access 01-12-2021 | Bronchoscopy | Case report

Congenital bronchial atresia complicated by a lung abscess due to Aspergillus fumigatus: a case report

Authors: Gaku Kuwabara, Risa Sone, Waki Imoto, Kazushi Yamairi, Wataru Shibata, Kazuhiro Oshima, Koichi Yamada, Kazuhiro Yamada, Tetsuya Watanabe, Kazuhisa Asai, Hiroaki Komatsu, Nobuhiro Izumi, Noritoshi Nishiyama, Tomoya Kawaguchi, Hiroshi Kakeya

Published in: BMC Pulmonary Medicine | Issue 1/2021

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Abstract

Background

Congenital bronchial atresia is a rare pulmonary abnormality characterized by the disrupted communication between the central and the peripheral bronchus and is typically asymptomatic. Although it can be symptomatic especially when infections occur in the involved areas, fungal infections are rare complications in patients with bronchial atresia. We report a case of congenital bronchial atresia complicated by a fungal infection.

Case presentation

A 30-year-old man with no previous history of immune dysfunction was brought to a nearby hospital and diagnosed with a left lung abscess. Although antimicrobial treatment was administered, it was ineffective, and he was transferred to our hospital. Since diagnostic imaging findings and bronchoscopy suggested congenital bronchial atresia and a fungal infection, he was treated with voriconazole and surgical resection was subsequently performed. A tissue culture detected Aspergillus fumigatus and histopathological findings were compatible with bronchial atresia. After discharge, he remained well and voriconazole was discontinued 5 months after the initiation of therapy.

Conclusion

Bronchial atresia is a rare disease that is seldom complicated by a fungal infection, which is also a rare complication; however, physicians should consider fungal infections in patients with bronchial atresia who present with infections resistant to antimicrobial treatment.
Literature
1.
go back to reference Ramsey BH, Byron FX. Mucocele, congenital bronchiectasis, and bronchogenic cyst. J Thorac Surg. 1953;26:21–30.CrossRef Ramsey BH, Byron FX. Mucocele, congenital bronchiectasis, and bronchogenic cyst. J Thorac Surg. 1953;26:21–30.CrossRef
2.
go back to reference Wang Y, Dai W, Sun Y, Chu X, Yang B, Zhao M. Congenital bronchial atresia: diagnosis and treatment. Int J Med Sci. 2012;9:207–12.CrossRef Wang Y, Dai W, Sun Y, Chu X, Yang B, Zhao M. Congenital bronchial atresia: diagnosis and treatment. Int J Med Sci. 2012;9:207–12.CrossRef
3.
go back to reference Lacquet LK, Fornhoff M, Dierickx R, Buyssens N. Bronchial atresia with corresponding segmental pulmonary emphysema. Thorax. 1971;26:68–73.CrossRef Lacquet LK, Fornhoff M, Dierickx R, Buyssens N. Bronchial atresia with corresponding segmental pulmonary emphysema. Thorax. 1971;26:68–73.CrossRef
4.
go back to reference Raynor AC, Capp MP, Sealy WC. Lobar emphysema of infancy: diagnosis, treatment, and etiological aspects-collective review. Ann Thorac Surg. 1967;4:374–85.CrossRef Raynor AC, Capp MP, Sealy WC. Lobar emphysema of infancy: diagnosis, treatment, and etiological aspects-collective review. Ann Thorac Surg. 1967;4:374–85.CrossRef
5.
go back to reference Yamamoto J, Shimanouchi M, Hashizume T, Suito T. Acquired bronchial atresia due to endobronchial tuberculosis. Kyobu Geka. 2015;68:836–9 (in Japanese).PubMed Yamamoto J, Shimanouchi M, Hashizume T, Suito T. Acquired bronchial atresia due to endobronchial tuberculosis. Kyobu Geka. 2015;68:836–9 (in Japanese).PubMed
6.
go back to reference Psathakis K, Lachanis S, Kotoulas C, Koutoulidis V, Panagou P, Tsintiris K, et al. The prevalence of congenital bronchial atresia in males. Monaldi Arch Chest Dis. 2014;61:28–34. Psathakis K, Lachanis S, Kotoulas C, Koutoulidis V, Panagou P, Tsintiris K, et al. The prevalence of congenital bronchial atresia in males. Monaldi Arch Chest Dis. 2014;61:28–34.
7.
go back to reference Jederlinic PJ, Sicilian LS, Baigelman W, Gaensler EA. Congenital bronchial atresia. A report of four cases and a review of the literature. Medicine. 1987;66:73–83.CrossRef Jederlinic PJ, Sicilian LS, Baigelman W, Gaensler EA. Congenital bronchial atresia. A report of four cases and a review of the literature. Medicine. 1987;66:73–83.CrossRef
8.
go back to reference Seo T, Ando H, Kaneko K, Ono Y, Tainaka T, Sumida W, et al. Two cases of prenatally diagnosed congenital lobar emphysema caused by lobar bronchial atresia. J Pediatr Surg. 2006;41:e17-20.CrossRef Seo T, Ando H, Kaneko K, Ono Y, Tainaka T, Sumida W, et al. Two cases of prenatally diagnosed congenital lobar emphysema caused by lobar bronchial atresia. J Pediatr Surg. 2006;41:e17-20.CrossRef
9.
go back to reference Matsushima H, Takayanagi N, Satoh M, Kurashima K, Kanauchi T, Hoshi T, et al. Congenital bronchial atresia: radiologic findings in nine patients. J Comput Assist Tomogr. 2002;26:860–4.CrossRef Matsushima H, Takayanagi N, Satoh M, Kurashima K, Kanauchi T, Hoshi T, et al. Congenital bronchial atresia: radiologic findings in nine patients. J Comput Assist Tomogr. 2002;26:860–4.CrossRef
10.
go back to reference van Klaveren RJ, Morshuis WJ, Lacquet LK, Cox AL, Festen J, Heystraten FM. Congenital bronchial atresia with regional emphysema associated with pectus excavatum. Thorax. 1992;47:1082–3.CrossRef van Klaveren RJ, Morshuis WJ, Lacquet LK, Cox AL, Festen J, Heystraten FM. Congenital bronchial atresia with regional emphysema associated with pectus excavatum. Thorax. 1992;47:1082–3.CrossRef
11.
go back to reference Bucher U, Reid E. Development of the intrasegmental bronchial tree: the pattern of branching and development of cartilage at various stages of intra-uterine life. Thorax. 1961;16:207–18.CrossRef Bucher U, Reid E. Development of the intrasegmental bronchial tree: the pattern of branching and development of cartilage at various stages of intra-uterine life. Thorax. 1961;16:207–18.CrossRef
12.
go back to reference Matsuoka K, Ueda M, Miyamoto Y. Mycobacterium Avium infection complicating congenital bronchial atresia. Asian Cardiovasc Thorac Ann. 2016;24:808–10.CrossRef Matsuoka K, Ueda M, Miyamoto Y. Mycobacterium Avium infection complicating congenital bronchial atresia. Asian Cardiovasc Thorac Ann. 2016;24:808–10.CrossRef
13.
go back to reference Yousef AA. Bronchial atresia in a neonate with congenital cytomegalovirus infection. Ann Thorac Med. 2013;8:231–3.CrossRef Yousef AA. Bronchial atresia in a neonate with congenital cytomegalovirus infection. Ann Thorac Med. 2013;8:231–3.CrossRef
14.
go back to reference Kameyama K, Okumura N, Kokado Y, Miyoshi K, Matsuoka T, Nakagawa T. Congenital bronchial atresia associated with spontaneous pneumothorax. Ann Thorac Surg. 2006;82:324–7.CrossRef Kameyama K, Okumura N, Kokado Y, Miyoshi K, Matsuoka T, Nakagawa T. Congenital bronchial atresia associated with spontaneous pneumothorax. Ann Thorac Surg. 2006;82:324–7.CrossRef
15.
go back to reference Alebna PA, Kim DH, Chaudhary R, Tavares M. Pulmonary hypertension and congenital bronchial atresia: a time factor association. Respir Med Case Rep. 2019;28:100882.PubMedPubMedCentral Alebna PA, Kim DH, Chaudhary R, Tavares M. Pulmonary hypertension and congenital bronchial atresia: a time factor association. Respir Med Case Rep. 2019;28:100882.PubMedPubMedCentral
16.
go back to reference Al-Qadi MA, Reddy DRJ, Larsen BT, Iyer VN. Chronic pulmonary aspergillosis complicating bronchial atresia. Case Rep Med. 2014;2014:208963.CrossRef Al-Qadi MA, Reddy DRJ, Larsen BT, Iyer VN. Chronic pulmonary aspergillosis complicating bronchial atresia. Case Rep Med. 2014;2014:208963.CrossRef
17.
go back to reference Eira IM, Carvalho R, Carbalho DV, Ângela C. Lung abscess in an immunocompromised patient: clinical presentation and management challenges. BMJ Case Rep. 2019;12:e230756.CrossRef Eira IM, Carvalho R, Carbalho DV, Ângela C. Lung abscess in an immunocompromised patient: clinical presentation and management challenges. BMJ Case Rep. 2019;12:e230756.CrossRef
18.
go back to reference Cappeliez S, Lenoir S, Validire P, Gossot D. Totally endoscopic lobectomy and segmentectomy for congenital bronchial atresia. Eur J Cardiothorac Surg. 2009;36:222–4.CrossRef Cappeliez S, Lenoir S, Validire P, Gossot D. Totally endoscopic lobectomy and segmentectomy for congenital bronchial atresia. Eur J Cardiothorac Surg. 2009;36:222–4.CrossRef
19.
go back to reference Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:e1-60.CrossRef Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:e1-60.CrossRef
Metadata
Title
Congenital bronchial atresia complicated by a lung abscess due to Aspergillus fumigatus: a case report
Authors
Gaku Kuwabara
Risa Sone
Waki Imoto
Kazushi Yamairi
Wataru Shibata
Kazuhiro Oshima
Koichi Yamada
Kazuhiro Yamada
Tetsuya Watanabe
Kazuhisa Asai
Hiroaki Komatsu
Nobuhiro Izumi
Noritoshi Nishiyama
Tomoya Kawaguchi
Hiroshi Kakeya
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2021
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/s12890-020-01367-5

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