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BMC Pulmonary Medicine

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Open Access 01-12-2019 | Research article

Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study

Authors: Xiao-feng Xiong, Li Xu, Li-li Fan, De-yun Cheng, Bi-xia Zheng

Published in: BMC Pulmonary Medicine | Issue 1/2019

Abstract

Background

Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis.

Methods

All patients treated with SEMSs from July 2003 to June 2016 were reviewed for symptomatic response, complications, and long-term outcomes.

Results

Total 131 stents were successfully deployed in 116 patients. Ninety-eight patients demonstrated clinical improvement after stent insertion (84.48%; 95% confidence interval [CI]: 77.89–91.07). Compared with uncovered stents, covered stents were associated with more sore throats complaints or chest pain (13.89% versus 28.81%, P = 0.036) and with higher incidences of major and minor granulation tissue formation and with recurrent stenosis (4.17% versus 15.25%, P = 0.029; 11.11% versus 37.29%, P < 0.0001 and 9.72% versus 28.81%, P = 0.005, respectively). Each covered and uncovered stent developing tissue hyperplasia required a median of 2 (range: 1–15) and 1(range: 1–7) fibrobronchoscope with electrocautery therapy, respectively. At follow-up (median: 1276 days; range: 2–4263), 68 patients had complete resolution, 15 remained under interventional treatment, 8 had bronchial occlusions, 7 underwent surgery, 14 were lost to follow-up, and 4 died of stent unrelated causes.

Conclusion

SEMS placement achieved most clinical improvement among patients in our study, if adequate endotracheal measures were used to address stent-related complications. The use of permanent SEMSs for benign tracheobronchial stenosis was effective and safe for the majority of patients in a long-term follow-up.

Trial registration

The study has been retrospectively registered in the China Clinical Trial Registry on October 21, 2018 (Registry ID: ChiCTR1800019024).

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Title: Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study
Authors: Xiao-feng Xiong
Li Xu
Li-li Fan
De-yun Cheng
Bi-xia Zheng
Publication date: 01-12-2019
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2019
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-019-0793-y

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Conclusion

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