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BMC Pulmonary Medicine

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Open Access 01-12-2016 | Research article

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

Authors: Zunjia Wen, Chao Wu, Feifei Cui, Haiying Zhang, Binbin Mei, Meifen Shen

Published in: BMC Pulmonary Medicine | Issue 1/2016

Abstract

Background

Saline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear.

Objectives

To investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy.

Methods

Sprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy (SEM).

Results

Study results revealed that tracheostomy gave rise to the increase of sputum viscosity, TNF-α and AQP4 expression, mucosa and cilia damage, yet the saline fluid nebulization could significantly decrease the changes of those indicators, besides, the hypertonic, isotonic and hypertonic saline nebulization produced different efficacy.

Conclusions

Osmolality plays an important role in the saline fluid nebulization after tracheostomy, and 3% saline fluid nebulization seems to be more beneficial, further studies on the role of osmolality in saline fluid nebulization are warranted.

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Title: The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?
Authors: Zunjia Wen
Chao Wu
Feifei Cui
Haiying Zhang
Binbin Mei
Meifen Shen
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2016
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-016-0342-x

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Methods

Results

Conclusions

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