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Open Access 01-12-2016 | Research article

Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension

Authors: Lars Harbaum, Emilia Renk, Sara Yousef, Antonia Glatzel, Nicole Lüneburg, Jan K. Hennigs, Tim Oqueka, Hans J. Baumann, Djordje Atanackovic, Ekkehard Grünig, Rainer H. Böger, Carsten Bokemeyer, Hans Klose

Published in: BMC Pulmonary Medicine | Issue 1/2016

Abstract

Background

Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients.

Methods

Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10 healthy subjects. Phenotypic characterization of peripheral blood mononuclear cells and circulating cytokines were assessed before, directly after and 1 h after exercise.

Results

Before exercise testing, IPAH patients showed elevated Th2 lymphocytes, regulatory T lymphocytes, IL-6, and TNF-alpha, whilst Th1/Th17 lymphocytes and IL-4 were reduced. In IPAH patients but not in healthy subject, exercise caused an immediate relative decrease of Th17 lymphocytes and a sustained reduction of IL-1-beta and IL-6. The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients.

Conclusions

Exercise seems to be safe from an immune and inflammatory point of view in IPAH patients. Our results demonstrate that exercise does not aggravate the inflammatory state and seems to elicit an immune-modulating effect in IPAH patients.

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Title: Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension
Authors: Lars Harbaum
Emilia Renk
Sara Yousef
Antonia Glatzel
Nicole Lüneburg
Jan K. Hennigs
Tim Oqueka
Hans J. Baumann
Djordje Atanackovic
Ekkehard Grünig
Rainer H. Böger
Carsten Bokemeyer
Hans Klose
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2016
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-016-0301-6

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