Top

BMC Public Health

Published in:

Open Access 01-12-2021 | Rabies | Research

Protective vaccinations during pregnancy - adult Poles knowledge in this area

Authors: Józefa Dąbek, Oskar Sierka, Halina Kulik, Zbigniew Gąsior

Published in: BMC Public Health | Issue 1/2021

Abstract

Background

The vaccine is a preparation of biological origin containing antigens that stimulate the body’s immune system to produce acquired immunity. Vaccines can contain killed or “live” (attenuated) microorganisms as well as fragments of these (antigens). Although many vaccines are used routinely in pregnancy to provide a seroprotective immune response for mother, fetus and neonate there is much controversy over their use during this unique time. The aim of the study was to find out about the knowledge of adult Poles on the use of preventive vaccinations during pregnancy.

Methods

The study involved 700 people (100%) aged 18 to 80 years (\( \overline{x} \) = 32.16 ± 16.46). Most of the respondents were women (511; 73%). The study consisted of 9 questions about preventive vaccinations of pregnant women and 5 questions about members of the studied group. The aforementioned questions formed the basis of the preparation of the presented article.

Results

A significant part of respondents (322; 46%) did not have knowledge on the topic of safeness of using preventive vaccinations during pregnancy, 196 (28%) respondents believed that such procedure is not safe. Most of the respondents (371; 53%) did not know about the possibility of using “live” vaccines during pregnancy. 14 (2%) of respondents believed that pregnancy should be terminated in case of administration of a “live” vaccine to a pregnant woman. According to 294 (42%) respondents, vaccinations with “live” vaccines should be completed at least 3 months before the planned pregnancy. The subjects were not aware of the issue of post-exposure vaccination against tetanus and rabies among pregnant women. The respondents’ responses were divided on the issue of the safest trimester of pregnancy for vaccine administration. Almost 1/3 of the respondents (203; 29%) indicated the third trimester as the safest for their performance.

Conclusion

The knowledge of the surveyed group, the majority of whom were women, about the use of vaccinations before and during pregnancy was unsatisfactory. There is a need to educate the public about the benefits and risks of performing or avoiding preventive vaccinations during pregnancy.

Available only for authorised users

Alici D, Sayiner A, Unal S. Barriers to adult immunization and solutions: personalized approaches. Hum Vaccines Immunother. 2017;13(1):213–5. https://doi.org/10.1080/21645515.2016.1234556.CrossRef

Rees A, Jones N, Jenkins B, Richards O, Cronin J, Thornton C. Maternal immunometabolic adaptation in pregnancy. J Immunol. 2020;204(1 Supplement):73–4.

Than NG, Hahn S, Rossi SW, Szekeres-Bartho J. Editorial: Fetal-Maternal Immune Interactions in Pregnancy. Front Immunol. 2019;10:2729. https://doi.org/10.3389/fimmu.2019.02729 PMID: 31827469; PMCID: PMC6890855.CrossRefPubMedPubMedCentral

Piccinni MP. T cell tolerance towards the fetal allograft. J Reprod Immunol. 2010;85(1):71–5. https://doi.org/10.1016/j.jri.2010.01.006.CrossRefPubMed

Hanssens S, Salzet M, Vinatier D. Aspects immunologiques de la grossesse [immunological aspect of pregnancy]. J Gynecol Obstet Biol Reprod (Paris). 2012;41(7):595–611. https://doi.org/10.1016/j.jgyn.2012.07.001.CrossRef

MacLean M, Wilson R, Thomson J, Krishnamurthy S, Walker J. Immunological changes in normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 1992;43(3):167–72. https://doi.org/10.1016/0028-2243(92)90169-Y.CrossRefPubMed

Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. The immunology of successful pregnancy. Hum Reprod Update. 2003;9(4):347–57. https://doi.org/10.1093/humupd/dmg026.CrossRefPubMed

Kochhar S, Bauwens J, Bonhoeffer J. GAIA project participants. Electronic address: http://www.gaia-consortium.net/Safety assessment of immunization in pregnancy. Vaccine. 2017;35(48):6469–71. https://doi.org/10.1016/j.vaccine.2017.09.033.CrossRefPubMedPubMedCentral

Verma R, Khanna P, Dhankar M. Vaccination during pregnancy: Today's need in India. Hum Vaccines Immunother. 2016;12(3):668–70. https://doi.org/10.1080/21645515.2015.1093265.CrossRef

10.

Fouda G, Martinez D, Swamy G, Permar S. The impact of IgG transplacental transfer on early life immunity. Immunohorizons. 2018;2(1):14–25. https://doi.org/10.4049/immunohorizons.1700057.CrossRefPubMedPubMedCentral

11.

Giles M, Krishnaswamy S, Wallace E. Maternal immunisation: What have been the gains? Where are the gaps? What does the future hold? F1000Res. 2018;7:F1000 Faculty Rev-1733.CrossRef

12.

Doherty M, Schmidt-Ott R, Santos J, et al. Vaccination of special populations: protecting the vulnerable. Vaccine. 2016;34(52):6681–90. https://doi.org/10.1016/j.vaccine.2016.11.015.CrossRefPubMed

13.

Regan A. The safety of maternal immunization. Hum Vaccines Immunother. 2016;12(12):3132–6. https://doi.org/10.1080/21645515.2016.1222341.CrossRef

14.

Arora M, Lakshmi R. Maternal vaccines-safety in pregnancy [published online ahead of print, 2021 Feb 19]. Best Pract Res Clin Obstet Gynaecol. 2021;S1521–6934(21):00017–1. https://doi.org/10.1016/j.bpobgyn.2021.02.002.CrossRef

15.

Shimabukuro TT, Kim SY, Myers TR, et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons [published online ahead of print, 2021 Apr 21]. N Engl J Med. 2021. https://doi.org/10.1056/NEJMoa2104983.

16.

H- Giles ML, Krishnaswamy S, Macartney K, Cheng A. The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review. Hum Vaccin Immunother. 2019;15(3):687–99. https://doi.org/10.1080/21645515.2018.1540807.CrossRef

17.

Groom HC, Irving SA, Koppolu P, Smith N, Vazquez-Benitez G, Kharbanda EO, et al. Uptake and safety of hepatitis B vaccination during pregnancy: a vaccine safety datalink study. Vaccine. 2018;36(41):6111–6. https://doi.org/10.1016/j.vaccine.2018.08.074.CrossRefPubMedPubMedCentral

18.

Sperling RS. Riley LE; immunization and emerging infections expert work group. Influenza vaccination, pregnancy safety, and risk of early pregnancy loss. Obstet Gynecol. 2018;131(5):799–802. https://doi.org/10.1097/AOG.0000000000002573.CrossRefPubMed

19.

Committee Opinion No ACOG. 732: Influenza Vaccination During Pregnancy. Obstet Gynecol. 2018;131(4):e109–14. https://doi.org/10.1097/AOG.0000000000002588.CrossRef

20.

Committee Opinion No ACOG. 741: maternal immunization. Obstet Gynecol. 2018;131(6):e214–7. https://doi.org/10.1097/AOG.0000000000002662.CrossRef

21.

Omyła-Rudzka M. Attitude towards vaccination against COVID-19 and influenza. CBOS 2020. https://www.cbos.pl/SPISKOM.POL/2020/K_154_20.PDF. Accessed 4 May 2020.

22.

Kilich E, Dada S, Francis MR, Tazare J, Chico RM, Paterson P, et al. Factors that influence vaccination decision-making among pregnant women: a systematic review and meta-analysis. PLoS One. 2020;15(7):e0234827. https://doi.org/10.1371/journal.pone.0234827.CrossRefPubMedPubMedCentral

23.

D'Alessandro A, Napolitano F, D'Ambrosio A, Angelillo IF. Vaccination knowledge and acceptability among pregnant women in Italy. Hum Vaccin Immunother. 2018;14(7):1573–9. https://doi.org/10.1080/21645515.2018.1483809.CrossRefPubMedPubMedCentral

24.

Skirrow H, Barnett S, Bell S, et al. Women's views on accepting COVID-19 vaccination during and after pregnancy, and for their babies: A multi-methods study in the UK. r medRxiv. 2021;04(30):21256240. https://doi.org/10.1101/2021.04.30.21256240.CrossRef

25.

Bartolo S, Deliege E, Mancel O, et al. Determinants of influenza vaccination uptake in pregnancy: a large single-Centre cohort study. BMC Pregnancy Childbirth. 2019;19(1):510. Published 2019 Dec 19. https://doi.org/10.1186/s12884-019-2628-5.CrossRefPubMedPubMedCentral

26.

Wilcox CR, Calvert A, Metz J, Kilich E, MacLeod R, Beadon K, et al. Determinants of influenza and pertussis vaccination uptake in pregnancy: a multicenter questionnaire study of pregnant women and healthcare professionals. Pediatr Infect Dis J. 2019;38(6):625–30. https://doi.org/10.1097/INF.0000000000002242.CrossRefPubMed

27.

Maher L, Hope K, Torvaldsen S, Lawrence G, Dawson A, Wiley K, et al. Influenza vaccination during pregnancy: coverage rates and influencing factors in two urban districts in Sydney. Vaccine. 2013;31(47):5557–64. https://doi.org/10.1016/j.vaccine.2013.08.081.CrossRefPubMed

28.

Yuen CY, Tarrant M. Determinants of uptake of influenza vaccination among pregnant women - a systematic review. Vaccine. 2014;32(36):4602–13. https://doi.org/10.1016/j.vaccine.2014.06.067.CrossRefPubMed

29.

Mohammed H, Clarke M, Koehler A, Watson M, Marshall H. Factors associated with uptake of influenza and pertussis vaccines among pregnant women in South Australia. PLoS One. 2018;13(6):e0197867. Published 2018 Jun 14. https://doi.org/10.1371/journal.pone.0197867.CrossRefPubMedPubMedCentral

30.

Barrett T, McEntee E, Drew R, et al. Influenza vaccination in pregnancy: vaccine uptake, maternal and healthcare providers' knowledge and attitudes. A quantitative study. BJGP Open. 2018;2(3):bjgpopen18X101599. Published 2018 Aug 8. https://doi.org/10.3399/bjgpopen18X101599.CrossRefPubMedPubMedCentral

31.

Kroger A, Bahta L, Hunter P. General Best Practice Guidelines for Immunization. Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/downloads/general-recs.pdf. Accessed 4 Dec 2020.

32.

Swamy G, Beigi R. Maternal benefits of immunization during pregnancy. Vaccine. 2015;33(47):6436–40. https://doi.org/10.1016/j.vaccine.2015.08.035.CrossRefPubMed

33.

Vojtek I, Dieussaert I, Doherty T, et al. Maternal immunization: where are we now and how to move forward? Ann Intern Med. 2018;50(3):193–208.CrossRef

34.

Marshall H, McMillan M, Andrews R, Macartney K, Edwards K. Vaccines in pregnancy: the dual benefit for pregnant women and infants. Hum Vaccines Immunother. 2016;12(4):848–56. https://doi.org/10.1080/21645515.2015.1127485.CrossRef

35.

Healy CM, Rench MA, Montesinos DP, Ng N, Swaim LS. Knowledge and attitiudes of pregnant women and their providers towards recommendations for immunization during pregnancy. Vaccine. 2015;33(41):5445–51. https://doi.org/10.1016/j.vaccine.2015.08.028.CrossRefPubMed

36.

Bartolo S, Mancel O, Deliege E, Carpentier S, Dessein R, Faure K, et al. Determinants of pregnant women’s knowledge about influenza and the influenza vaccine: a large, single-Centre cohort study. PLoS One. 2020;15(7):e0236793. https://doi.org/10.1371/journal.pone.0236793.CrossRefPubMedPubMedCentral

37.

Chang S, Ball R, Braun M. Elective termination of pregnancy after vaccination reported to the vaccine adverse event reporting system (VAERS): 1990-2006. Vaccine. 2008;26(19):2428–32. https://doi.org/10.1016/j.vaccine.2008.02.052.CrossRefPubMed

38.

Laris-González A, Bernal-Serrano D, Jarde A, Kampmann B. Safety of administering live vaccines during pregnancy: a systematic review and meta-analysis of pregnancy outcomes. Vaccines. 2020;8(1):124. https://doi.org/10.3390/vaccines8010124.CrossRefPubMedCentral

39.

Chief Sanitary Inspector communicate from 26 October 2020 regarding the Protective Vaccinations Program for 2020. http://dziennikmz.mz.gov.pl/DUM_MZ/2020/90/akt.pdf. Accessed 4 May 2020.

40.

McMillan M, Clarke M, Parrella A, Fell D, Amirthalingam G, Marshall H. Safety of tetanus, diphtheria, and pertussis vaccination during pregnancy: a systematic review. Obstet Gynaecol. 2017;129(3):560–73. https://doi.org/10.1097/AOG.0000000000001888.CrossRef

41.

Fayaz A, Simani S, Fallahian V, Eslamifar A, Hazrati M, Farahtaj F, et al. Rabies antibody levels in pregnant women and their newborns after rabies post-exposure prophylaxis. Iran J Reprod Med. 2012;10(2):161–3.PubMedPubMedCentral

42.

Faucette N, Pawlitz D, Pei B, Yao F, Chen K. Immunization of pregnant women: future of early infant protection. Hum Vaccines Immunother. 2015;11(11):2549–55. https://doi.org/10.1080/21645515.2015.1070984.CrossRef

43.

Dąbek J, Gierek D, et al. Vaccination against influenza – recommendations and reality in the assessments of patients of cardiology and family physician center. Pol Merkur Lekarski. 2011;31(183):159–64.PubMed

44.

Nunes C, Cutland L, Madhi A. Influenza vaccination during pregnancy and protection against pertussis. N Engl J Med. 2018;378(13):1257–8. https://doi.org/10.1056/NEJMc1705208.CrossRefPubMedPubMedCentral

45.

WHO Safety of Immunization during Pregnancy: A Review of the Evidence. https://www.who.int/vaccine_safety/publications/safety_pregnancy_nov2014.pdf (Accessed: 4.05.2020).

46.

Carlson A, Thung S, Norwitz E. H1N1 influenza in pregnancy: what all obstetric care providers ought to know. Obstet Gynecol. 2009;2(3):139–45.

47.

Grohskopf L, Alyanak E, Broder K, Walter E, Fry A, Jernigan D. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2019–20 Influenza Season. MMWR Recommendations Report. 2019;68(RR-3):1–21.

48.

Mak DB, Regan AK, Vo DT, Effler PV. Antenatal influenza and pertussis vaccination in Western Australia: a cross-sectional survey of vaccine uptake and influencing factors. BMC Pregnancy Childbirth. 2018;18(1):416. https://doi.org/10.1186/s12884-018-2051-3.CrossRefPubMedPubMedCentral

49.

Vishram B, Letley L. Jan Van Hoek a, et al. vaccination in pregnancy: attitudes of nurses, midwives and health visitors in England. Hum Vaccin Immunother. 2018;14(1):179–88. https://doi.org/10.1080/21645515.2017.1382789.CrossRefPubMed

50.

Blanchard-Rohner G, Meier S, Ryser J, Schaller D, Combescure C, Yudin MH, et al. Acceptability of maternal immunization against influenza: the critical role of obstetricians. J Matern Fetal Neonatal Med. 2012;25(9):1800–9. https://doi.org/10.3109/14767058.2012.663835.CrossRefPubMed

51.

Heuchan A, Isaacs D. The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. Australasian subgroup in Paediatric infectious diseases of the Australasian Society for Infectious Diseases. Med J Aust. 2001;174(6):288–92.CrossRef

52.

Levin M, Duchon J, Swamy G, Gershon A. Varicella zoster immune globulin (VARIZIG) administration up to 10 days after varicella exposure in pregnant women, immunocompromised participants, and infants: varicella outcomes and safety results from a large, open-label, expanded-access program. PLoS One. 2019;14(7):e0217749. https://doi.org/10.1371/journal.pone.0217749.CrossRefPubMedPubMedCentral

Title: Protective vaccinations during pregnancy - adult Poles knowledge in this area
Authors: Józefa Dąbek
Oskar Sierka
Halina Kulik
Zbigniew Gąsior
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Rabies
Vaccination
Tetanus
Published in: BMC Public Health / Issue 1/2021
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-021-11336-0

At a glance: The STEP trials

Springer Medicine

Protective vaccinations during pregnancy - adult Poles knowledge in this area

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2021

Factors influencing childhood immunisation uptake in Africa: a systematic review

Prevalence and socioeconomic burden of diabetes mellitus in South Korean adults: a population-based study using administrative data

Influence of the request and purchase of television advertised foods on dietary intake and obesity among children in China

The potential role of network-oriented interventions for survivors of sexual and gender-based violence among asylum seekers in Belgium

The impact of social capital and mental health on medication adherence among older people living with HIV (PLWH)

Determinants of maternal health four weeks after delivery: cross-sectional findings from the KUNO-kids health study