Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2019

Open Access 01-12-2019 | Premature Birth | Research article

Effect of ambient air pollution on premature SGA in Changzhou city, 2013–2016: a retrospective study

Authors: Shushu Li, Huaiyan Wang, Haiting Hu, Zeying Wu, Kejin Chen, Zhilei Mao

Published in: BMC Public Health | Issue 1/2019

Login to get access

Abstract

Background

Air pollution is becoming an increased burden to the world. Previous studies have confirmed its effects on adverse birth outcomes, but few associated with premature small for gestational age (SGA). We report a retrospective cohort study conducted in Changzhou city to evaluate the association between air pollutants (PM2.5, SO2 and NO2) and premature SGA during pregnancy.

Methods

A total of 46,224 births were collected from January, 2013 to December, 2016, in Changzhou Maternity and Child Health Care Hospital, finally 2709 preterm births were admitted for study. Corresponding air monitoring data were collected from Changzhou Environmental Protection Agency. Generalized estimating equations were used to examine the association between these air pollutants and premature SGA controlling for individual covariates in single- and multi-pollutant models.

Results

We found that, in the third trimester, every 10 μg/m3 increments in PM2.5 concentration were associated with premature SGA (OR = 1.18, 95% CI: 1.03–2.83; OR = 1.37, 95% CI: 1.03–3.58) in two- and three-pollutants models. In the whole gestation, a 10 μg/m3 increment in PM2.5 concentration in two- and three-pollutant models were related to premature SGA (OR = 1.53, 95% CI: 1.38–2.47; OR = 1.73, 95% CI: 1.18–2.57). The OR (95% CI) of premature SGA were increasing across quintiles of PM2.5, SO2, NO2 concentrations during the whole gestation period adjusting for confounders (P for trend < 0.001).

Conclusions

These results indicated that pregnant women exposed to PM2.5, combined with other pollutants in the third trimester have a higher risk to deliver premature SGA babies, providing further evidence linking PM2.5 and pregnancy outcomes.
Literature
1.
Xia X, Zhang A, Liang S, Qi Q, Jiang L, Ye Y. The association between air pollution and population health risk for respiratory infection: a case study of Shenzhen, China. Int J Environ Res Public Health. 2017;14(9):950.CrossRefPubMed
2.
Mishra S. Is smog innocuous? Air pollution and cardiovascular disease. Indian Heart J. 2017;69(4):425–9.CrossRefPubMed
3.
Chen CY, Hung HJ, Chang KH, Hsu CY, Muo CH, Tsai CH, Wu TN. Long-term exposure to air pollution and the incidence of Parkinson's disease: a nested case-control study. PLoS One. 2017;12(8):e0182834.CrossRefPubMed
4.
Lin H, Guo Y, Kowal P, Airhihenbuwa CO, Di Q, Zheng Y, Zhao X, Vaughn MG, Howard S, Schootman M, et al. Exposure to air pollution and tobacco smoking and their combined effects on depression in six low- and middle-income countries. Br J Psychiatry. 2017;211(3):157–62.CrossRefPubMed
5.
Mueller N, Rojas-Rueda D, Basagana X, Cirach M, Cole-Hunter T, Dadvand P, Donaire-Gonzalez D, Foraster M, Gascon M, Martinez D, et al. Health impacts related to urban and transport planning: a burden of disease assessment. Environ Int. 2017;107:243–57.CrossRef
6.
Zhang Y, Peng M, Yu C, Zhang L. Burden of mortality and years of life lost due to ambient PM10 pollution in Wuhan, China. Environ Pollut. 2017;230:1073–80.CrossRef
7.
Anderson JO, Thundiyil JG, Stolbach A. Clearing the air: a review of the effects of particulate matter air pollution on human health. J Med Toxicol. 2012;8(2):166–75.CrossRef
8.
Arroyo V, Diaz J, Salvador P, Linares C. Impact of air pollution on low birth weight in Spain: an approach to a National Level Study. Environ Res. 2019;171:69–79.CrossRef
9.
Chang YC, Daza R, Hevner R, Costa LG, Cole TB. Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: evidence for a reelin-related pathogenic pathway induced by interleukin-6. Brain Behav Immun. 2019;78:105–15.CrossRef
10.
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, et al. Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts. Epidemiology. 2014;25(5):636–47.CrossRef
11.
Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet. 1997;349(9063):1436–42.CrossRef
12.
Gong X, Lin Y, Bell ML, Zhan FB. Associations between maternal residential proximity to air emissions from industrial facilities and low birth weight in Texas, USA. Environ Int. 2018;120:181–98.CrossRef
13.
Lavigne E, Burnett RT, Stieb DM, Evans GJ, Godri Pollitt KJ, Chen H, van Rijswijk D, Weichenthal S. Fine particulate air pollution and adverse birth outcomes: effect modification by regional nonvolatile oxidative potential. Environ Health Perspect. 2018;126(7):077012.CrossRefPubMed
14.
Lavigne E, Yasseen AS 3rd, Stieb DM, Hystad P, van Donkelaar A, Martin RV, Brook JR, Crouse DL, Burnett RT, Chen H, et al. Ambient air pollution and adverse birth outcomes: differences by maternal comorbidities. Environ Res. 2016;148:457–66.CrossRef
15.
Wallace ME, Grantz KL, Liu D, Zhu Y, Kim SS, Mendola P. Exposure to ambient air pollution and premature rupture of membranes. Am J Epidemiol. 2016;183(12):1114–21.CrossRefPubMed
16.
Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, Dominici F, Ross Z, Clougherty JE, Matte T. Ambient fine particulate matter, nitrogen dioxide, and preterm birth in new York City. Environ Health Perspect. 2016;124(8):1283–90.CrossRefPubMed
17.
Wylie BJ, Matechi E, Kishashu Y, Fawzi W, Premji Z, Coull BA, Hauser R, Ezzati M, Roberts DJ. Placental pathology associated with household air pollution in a cohort of pregnant women from Dar Es Salaam, Tanzania. Environ Health Perspect. 2017;125(1):134–40.CrossRef
18.
Estarlich M, Ballester F, Davdand P, Llop S, Esplugues A, Fernandez-Somoano A, Lertxundi A, Guxens M, Basterrechea M, Tardon A, et al. Exposure to ambient air pollution during pregnancy and preterm birth: a Spanish multicenter birth cohort study. Environ Res. 2016;147:50–8.CrossRef
19.
Sagiv SK, Mendola P, Loomis D, Herring AH, Neas LM, Savitz DA, Poole C. A time-series analysis of air pollution and preterm birth in Pennsylvania, 1997-2001. Environ Health Perspect. 2005;113(5):602–6.CrossRefPubMed
20.
Le HQ, Batterman SA, Wirth JJ, Wahl RL, Hoggatt KJ, Sadeghnejad A, Hultin ML, Depa M. Air pollutant exposure and preterm and term small-for-gestational-age births in Detroit, Michigan: long-term trends and associations. Environ Int. 2012;44:7–17.CrossRefPubMed
21.
Vuong NQ, Breznan D, Goegan P, O'Brien JS, Williams A, Karthikeyan S, Kumarathasan P, Vincent R. In vitro toxicoproteomic analysis of A549 human lung epithelial cells exposed to urban air particulate matter and its water-soluble and insoluble fractions. Part Fibre Toxicol. 2017;14(1):39.CrossRefPubMed
22.
Liu J, Xie K, Chen W, Zhu M, Shen W, Yuan J, Cheng Y, Geng L, Wang Y, Li Z, et al. Genetic variants, PM2.5 exposure level and global DNA methylation level: a multi-center population-based study in Chinese. Toxicol Lett. 2017;269:77–82.CrossRef
23.
Jain V, Dey S, Chowdhury S. Ambient PM2.5 exposure and premature mortality burden in the holy city Varanasi, India. Environ Pollut. 2017;226:182–9.CrossRef
24.
Lamichhane DK, Leem JH, Lee JY, Kim HC. A meta-analysis of exposure to particulate matter and adverse birth outcomes. Environ Health Toxicol. 2015;30:e2015011.CrossRefPubMed
25.
Padberg S, Wacker E, Meister R, Panse M, Weber-Schoendorfer C, Oppermann M, Schaefer C. Observational cohort study of pregnancy outcome after first-trimester exposure to fluoroquinolones. Antimicrob Agents Chemother. 2014;58(8):4392–8.CrossRefPubMed
26.
Kammerlander H, Nielsen J, Knudsen T, Kjeldsen J, Friedman S, Norgard BM. Anti-TNF-alpha use during the third trimester of pregnancy in women with moderate-severe inflammatory bowel disease and the risk of preterm birth and low birth weight. Inflamm Bowel Dis. 2017;23(11):1916–23.CrossRef
27.
Caldas JP, Vilela MM, Braghini CA, Mazzola TN, Marba ST. Antenatal maternal corticosteroid administration and markers of oxidative stress and inflammation in umbilical cord blood from very low birth weight preterm newborn infants. J Pediatr. 2012;88(1):61–6.CrossRef
28.
Souza MA, de Lourdes Brizot M, Biancolin SE, Schultz R, de Carvalho MHB, Francisco RPV, Zugaib M. Placental weight and birth weight to placental weight ratio in monochorionic and dichorionic growth-restricted and non-growth-restricted twins. Clinics (Sao Paulo). 2017;72(5):265–71.CrossRef
29.
Negi R, Pande D, Kumar A, Khanna RS, Khanna HD. Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates. J Matern Fetal Neonatal Med. 2012;25(8):1338–41.CrossRef
30.
Michikawa T, Morokuma S, Fukushima K, Kato K, Nitta H, Yamazaki S. Maternal exposure to air pollutants during the first trimester and foetal growth in Japanese term infants. Environ Pollut. 2017;230:387–93.CrossRef
Metadata
Title
Effect of ambient air pollution on premature SGA in Changzhou city, 2013–2016: a retrospective study
Authors
Shushu Li
Huaiyan Wang
Haiting Hu
Zeying Wu
Kejin Chen
Zhilei Mao
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2019
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-019-7055-z

Other articles of this Issue 1/2019

BMC Public Health 1/2019 Go to the issue

Research article

Effectiveness of community outreach HIV prevention programs in Vietnam: a mixed methods evaluation

Research article

Effects of applying a standardized assessment and evaluation protocol in housing adaptation implementation – results from a quasi-experimental study

Research article

Spanish validation endorsement of SDM-Q-9, a new approach

Debate

Applying infectious disease forecasting to public health: a path forward using influenza forecasting examples

Research article

Do four or more antenatal care visits increase skilled birth attendant use and institutional delivery in Bangladesh? A propensity-score matched analysis

Research article

Screen viewing behavior and sleep duration among children aged 2 and below