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Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Debate

The cholera outbreak in Yemen: lessons learned and way forward

Authors: Frederik Federspiel, Mohammad Ali

Published in: BMC Public Health | Issue 1/2018

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Abstract

The Yemen cholera outbreak has been driven by years of conflict and has now become the largest in epidemiologically recorded history with more than 1.2 million cases since the beginning of the outbreak in April, 2017. In this report we review and discuss the cholera management strategies applied by the major international humanitarian health organizations present in Yemen. We find the response by the organizations examined to have been more focused on case management than on outbreak prevention. Oral Cholera Vaccines (OCVs) were not delivered until nearly 16 months into the outbreak. A recent scale-up of the global OCV stockpile will hopefully allow for rapid mass deployment of the OCV in future humanitarian emergencies. Continuous funding to this stockpile will be crucial to maintain this option for prevention and control of cholera outbreaks. Of equal importance will be the timely recognition of the need for mass OCV deployment and development of more specific, comprehensive and actionable evidence-based frameworks to help guide this decision, however difficult this may be. The outbreak highlights the importance for international humanitarian health organizations to have a continuous discussion about whether and to what extent they should increase their focus on pre-emptively addressing the environmental determinants of communicable diseases in humanitarian emergencies. Strong advocacy from the public health community for peace and the protection of human health, by bringing to attention the public health impacts of armed conflict and keeping the world’s political leaders accountable to their actions, will remain crucial.
Literature
6.
go back to reference The Lancet. Yemen and cholera: a modern humanity test. Lancet. 2017;390(10095):626.PubMed The Lancet. Yemen and cholera: a modern humanity test. Lancet. 2017;390(10095):626.PubMed
20.
go back to reference Kennedy J, Harmer A, McCoy D. The political determinants of the cholera outbreak in Yemen. Lancet Glob Health. 2017;5(10):e970–e1.CrossRefPubMed Kennedy J, Harmer A, McCoy D. The political determinants of the cholera outbreak in Yemen. Lancet Glob Health. 2017;5(10):e970–e1.CrossRefPubMed
21.
go back to reference Dureab F, Shabib K, Albrecht J. The association of cholera outbreak with conflict-related factors in Yemen. Trop Med Int Health. 2017;22(Supplement 1):53. Dureab F, Shabib K, Albrecht J. The association of cholera outbreak with conflict-related factors in Yemen. Trop Med Int Health. 2017;22(Supplement 1):53.
22.
go back to reference The Lancet Gastroenterology & Hepatology. Health catastrophe: the toll of cholera in Yemen (Editorial). 2017;2(9):619. The Lancet Gastroenterology & Hepatology. Health catastrophe: the toll of cholera in Yemen (Editorial). 2017;2(9):619.
23.
25.
go back to reference The Lancet. Protecting health in Yemen. Lancet. 2016;388(10054):1852.PubMed The Lancet. Protecting health in Yemen. Lancet. 2016;388(10054):1852.PubMed
26.
27.
go back to reference Anh DD, Lopez AL, Thiem VD, Grahek SL, Duong TN, Park JK, et al. Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. PLoS Negl Trop Dis. 2011;5(1):e1006.CrossRefPubMedPubMedCentral Anh DD, Lopez AL, Thiem VD, Grahek SL, Duong TN, Park JK, et al. Use of oral cholera vaccines in an outbreak in Vietnam: a case control study. PLoS Negl Trop Dis. 2011;5(1):e1006.CrossRefPubMedPubMedCentral
28.
go back to reference Centers for Disease Control & Prevention (CDC). Cholera epidemic after increased civil conflict -- Monrovia, Liberia, June–September 2003. MMWR: Morbidity & Mortality Weekly Report. 2003;52(45):1093–5. Centers for Disease Control & Prevention (CDC). Cholera epidemic after increased civil conflict -- Monrovia, Liberia, June–September 2003. MMWR: Morbidity & Mortality Weekly Report. 2003;52(45):1093–5.
29.
go back to reference Lam E, Al-Tamimi W, Russell SP, Butt MO, Blanton C, Musani AS, et al. Oral cholera vaccine coverage during an outbreak and humanitarian crisis, Iraq, 2015. Emerg Infect Dis. 2017;23(1):38–45.CrossRefPubMedPubMedCentral Lam E, Al-Tamimi W, Russell SP, Butt MO, Blanton C, Musani AS, et al. Oral cholera vaccine coverage during an outbreak and humanitarian crisis, Iraq, 2015. Emerg Infect Dis. 2017;23(1):38–45.CrossRefPubMedPubMedCentral
38.
go back to reference Ahmadzai TK, Maburutse Z, Miller L, Ratnayake R. Protecting public health in Yemen. Lancet. 2016;388(10061):2739.CrossRefPubMed Ahmadzai TK, Maburutse Z, Miller L, Ratnayake R. Protecting public health in Yemen. Lancet. 2016;388(10061):2739.CrossRefPubMed
42.
go back to reference WHO. Health system in Yemen close to collapse. Bull World Health Organ. 2015;93(10):670–1.CrossRef WHO. Health system in Yemen close to collapse. Bull World Health Organ. 2015;93(10):670–1.CrossRef
43.
go back to reference Alamodi AA, Eshaq AM, Fothan AM, Bakather AM, Obad AS. Tackling preventable diseases in Yemen. Lancet. 2015;386(10010):2251–2.CrossRefPubMed Alamodi AA, Eshaq AM, Fothan AM, Bakather AM, Obad AS. Tackling preventable diseases in Yemen. Lancet. 2015;386(10010):2251–2.CrossRefPubMed
53.
go back to reference Qadri F, Islam T, Clemens JD. Cholera in Yemen - an old foe rearing its ugly head. N Engl J Med. 2017;377(21):2005–7.CrossRefPubMed Qadri F, Islam T, Clemens JD. Cholera in Yemen - an old foe rearing its ugly head. N Engl J Med. 2017;377(21):2005–7.CrossRefPubMed
56.
go back to reference Bi Q, Ferreras E, Pezzoli L, Legros D, Ivers LC, Date K, et al. Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2017;17(10):1080–8.CrossRefPubMedPubMedCentral Bi Q, Ferreras E, Pezzoli L, Legros D, Ivers LC, Date K, et al. Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2017;17(10):1080–8.CrossRefPubMedPubMedCentral
57.
58.
go back to reference WHO. Deployments from the oral cholera vaccine stockpile, 2013-2017. Wkly Epidemiol Rec. 2017;92(32):437–42. WHO. Deployments from the oral cholera vaccine stockpile, 2013-2017. Wkly Epidemiol Rec. 2017;92(32):437–42.
59.
go back to reference Desai SN, Pezzoli L, Alberti KP, Martin S, Costa A, Perea W, et al. Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era. Hum Vaccin Immunother. 2017;13(3):579–87.CrossRefPubMed Desai SN, Pezzoli L, Alberti KP, Martin S, Costa A, Perea W, et al. Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era. Hum Vaccin Immunother. 2017;13(3):579–87.CrossRefPubMed
60.
go back to reference Parker LA, Rumunu J, Jamet C, Kenyi Y, Lino RL, Wamala JF, et al. Neighborhood-targeted and case-triggered use of a single dose of oral cholera vaccine in an urban setting: feasibility and vaccine coverage. PLoS Negl Trop Dis. 2017;11(6):e0005652.CrossRefPubMedPubMedCentral Parker LA, Rumunu J, Jamet C, Kenyi Y, Lino RL, Wamala JF, et al. Neighborhood-targeted and case-triggered use of a single dose of oral cholera vaccine in an urban setting: feasibility and vaccine coverage. PLoS Negl Trop Dis. 2017;11(6):e0005652.CrossRefPubMedPubMedCentral
61.
go back to reference Teoh SL, Kotirum S, Hutubessy RCW, Chaiyakunapruk N. Global economic evaluation of oral cholera vaccine: a systematic review. Hum Vaccin Immunother. 2018;14(2):420–9.CrossRefPubMed Teoh SL, Kotirum S, Hutubessy RCW, Chaiyakunapruk N. Global economic evaluation of oral cholera vaccine: a systematic review. Hum Vaccin Immunother. 2018;14(2):420–9.CrossRefPubMed
62.
go back to reference Ilboudo PG, Le Gargasson JB. Delivery cost analysis of a reactive mass cholera vaccination campaign: a case study of Shanchol vaccine use in Lake Chilwa. Malawi BMC Infect Dis. 2017;17(1):779.CrossRefPubMed Ilboudo PG, Le Gargasson JB. Delivery cost analysis of a reactive mass cholera vaccination campaign: a case study of Shanchol vaccine use in Lake Chilwa. Malawi BMC Infect Dis. 2017;17(1):779.CrossRefPubMed
63.
go back to reference Poncin M, Zulu G, Voute C, Ferreras E, Muleya CM, Malama K, et al. Implementation research: reactive mass vaccination with single-dose oral cholera vaccine. Zambia Bull World Health Organ. 2018;96(2):86–93.CrossRefPubMed Poncin M, Zulu G, Voute C, Ferreras E, Muleya CM, Malama K, et al. Implementation research: reactive mass vaccination with single-dose oral cholera vaccine. Zambia Bull World Health Organ. 2018;96(2):86–93.CrossRefPubMed
64.
go back to reference Routh JA, Sreenivasan N, Adhikari BB, Andrecy LL, Bernateau M, Abimbola T, et al. Cost Evaluation of a Government-Conducted Oral Cholera Vaccination Campaign-Haiti, 2013. Am J Tropical Med and hygiene. 2017;97(4_Suppl):37–42.CrossRef Routh JA, Sreenivasan N, Adhikari BB, Andrecy LL, Bernateau M, Abimbola T, et al. Cost Evaluation of a Government-Conducted Oral Cholera Vaccination Campaign-Haiti, 2013. Am J Tropical Med and hygiene. 2017;97(4_Suppl):37–42.CrossRef
65.
go back to reference Teshome S, Desai S, Kim JH, Belay D, Mogasale V. Feasibility and costs of a targeted cholera vaccination campaign in Ethiopia. Hum Vaccin Immunother. 2018:1–7. Teshome S, Desai S, Kim JH, Belay D, Mogasale V. Feasibility and costs of a targeted cholera vaccination campaign in Ethiopia. Hum Vaccin Immunother. 2018:1–7.
69.
go back to reference Parker LA, Rumunu J, Jamet C, Kenyi Y, Lino RL, Wamala JF, et al. Adapting to the global shortage of cholera vaccines: targeted single dose cholera vaccine in response to an outbreak in South Sudan. Lancet Infect Dis. 2017;17(4):e123–e7.CrossRefPubMed Parker LA, Rumunu J, Jamet C, Kenyi Y, Lino RL, Wamala JF, et al. Adapting to the global shortage of cholera vaccines: targeted single dose cholera vaccine in response to an outbreak in South Sudan. Lancet Infect Dis. 2017;17(4):e123–e7.CrossRefPubMed
70.
go back to reference Qadri F, Wierzba TF, Ali M, Chowdhury F, Khan AI, Saha A, et al. Efficacy of a single-dose, inactivated Oral cholera vaccine in Bangladesh. N Engl J Med. 2016;374(18):1723–32.CrossRefPubMed Qadri F, Wierzba TF, Ali M, Chowdhury F, Khan AI, Saha A, et al. Efficacy of a single-dose, inactivated Oral cholera vaccine in Bangladesh. N Engl J Med. 2016;374(18):1723–32.CrossRefPubMed
71.
go back to reference Azman AS, Parker LA, Rumunu J, Tadesse F, Grandesso F, Deng LL, et al. Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study. Lancet Glob Health. 2016;4(11):e856–e63.CrossRefPubMed Azman AS, Parker LA, Rumunu J, Tadesse F, Grandesso F, Deng LL, et al. Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study. Lancet Glob Health. 2016;4(11):e856–e63.CrossRefPubMed
72.
go back to reference Rebaudet S, Gaudart J, Piarroux R. Vaccination against cholera in juba. Lancet Infect Dis. 2017;17(5):479–80.CrossRefPubMed Rebaudet S, Gaudart J, Piarroux R. Vaccination against cholera in juba. Lancet Infect Dis. 2017;17(5):479–80.CrossRefPubMed
73.
go back to reference Ciglenecki I, Azman AS, Rumunu J, Cabrol J-C, Luquero FJ. Vaccination against cholera in juba – Authors’ reply. Lancet Infect Dis. 2017;17(5):480–1.CrossRefPubMed Ciglenecki I, Azman AS, Rumunu J, Cabrol J-C, Luquero FJ. Vaccination against cholera in juba – Authors’ reply. Lancet Infect Dis. 2017;17(5):480–1.CrossRefPubMed
74.
go back to reference Pastor M, Pedraz JL, Esquisabel A. The state-of-the-art of approved and under-development cholera vaccines. Vaccine. 2013;31(38):4069–78.CrossRefPubMed Pastor M, Pedraz JL, Esquisabel A. The state-of-the-art of approved and under-development cholera vaccines. Vaccine. 2013;31(38):4069–78.CrossRefPubMed
77.
go back to reference Global Task Force on Cholera Control. Ending Cholera: A Global Roadmap to 2030. p. 2017. Global Task Force on Cholera Control. Ending Cholera: A Global Roadmap to 2030. p. 2017.
82.
go back to reference Rull M, Masson S, Peyraud N, Simonelli M, Ventura A, Dorion C, et al. The new WHO decision-making framework on vaccine use in acute humanitarian emergencies: MSF experience in Minkaman. South Sudan Confl Health. 2018;12:11.CrossRefPubMed Rull M, Masson S, Peyraud N, Simonelli M, Ventura A, Dorion C, et al. The new WHO decision-making framework on vaccine use in acute humanitarian emergencies: MSF experience in Minkaman. South Sudan Confl Health. 2018;12:11.CrossRefPubMed
83.
go back to reference Abubakar A, Azman AS, Rumunu J, Ciglenecki I, Helderman T, West H, et al. The first use of the global Oral cholera vaccine emergency stockpile: lessons from South Sudan. PLoS Med. 2015;12(11):e1001901.CrossRefPubMedPubMedCentral Abubakar A, Azman AS, Rumunu J, Ciglenecki I, Helderman T, West H, et al. The first use of the global Oral cholera vaccine emergency stockpile: lessons from South Sudan. PLoS Med. 2015;12(11):e1001901.CrossRefPubMedPubMedCentral
84.
go back to reference Schwerdtle P, Onekon CK, Recoche K. A quantitative systematic review and meta-analysis of the effectiveness of Oral cholera vaccine as a reactive measure in cholera outbreaks. Prehosp Disaster Med. 2018;33(1):2–6.CrossRefPubMed Schwerdtle P, Onekon CK, Recoche K. A quantitative systematic review and meta-analysis of the effectiveness of Oral cholera vaccine as a reactive measure in cholera outbreaks. Prehosp Disaster Med. 2018;33(1):2–6.CrossRefPubMed
Metadata
Title
The cholera outbreak in Yemen: lessons learned and way forward
Authors
Frederik Federspiel
Mohammad Ali
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-6227-6

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