Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Research article

Predictors of latent tuberculosis infection treatment completion in the US private sector: an analysis of administrative claims data

Authors: Erica L. Stockbridge, Thaddeus L. Miller, Erin K. Carlson, Christine Ho

Published in: BMC Public Health | Issue 1/2018

Login to get access

Abstract

Background

Factors that affect latent tuberculosis infection (LTBI) treatment completion in the US have not been well studied beyond public health settings. This gap was highlighted by recent health insurance-related regulatory changes that are likely to increase LTBI treatment by private sector healthcare providers. We analyzed LTBI treatment completion in the private healthcare setting to facilitate planning around this important opportunity for tuberculosis (TB) control in the US.

Methods

We analyzed a national sample of commercial insurance medical and pharmacy claims data for people ages 0 to 64 years who initiated daily dose isoniazid treatment between July 2011 and March 2014 and who had complete data. All individuals resided in the US. Factors associated with treatment completion were examined using multivariable generalized ordered logit models and bivariate Kruskal-Wallis tests or Spearman correlations.

Results

We identified 1072 individuals with complete data who initiated isoniazid LTBI treatment. Treatment completion was significantly associated with less restrictive health insurance, age < 15 years, patient location, use of interferon-gamma release assays, non-poverty, HIV diagnosis, immunosuppressive drug therapy, and higher cumulative counts of clinical risk factors.

Conclusions

Private sector healthcare claims data provide insights into LTBI treatment completion patterns and patient/provider behaviors. Such information is critical to understanding the opportunities and limitations of private healthcare in the US to support treatment completion as this sector’s role in protecting against and eliminating TB grows.
Appendix
Available only for authorised users
Literature
1.
Mancuso JD, Diffenderfer JM, Ghassemieh BJ, Horne DJ, Kao TC. The prevalence of latent tuberculosis infection in the United States. Am J Respir Crit Care Med. 2016;194(4):501–9.CrossRefPubMed
2.
Miramontes R, Hill AN, Yelk Woodruff RS, Lambert LA, Navin TR, Castro KG, LoBue PA. Tuberculosis infection in the United States: prevalence estimates from the National Health and nutrition examination survey, 2011-2012. PLoS One. 2015;10(11):e0140881.CrossRefPubMedPubMedCentral
3.
Kahwati LC, Feltner C, Halpern M, Woodell CL, Boland E, Amick HR, Palmieri Weber R, Jonas DE: Screening for Latent Tuberculosis Infection in Adults: An Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 142. AHRQ Publication No. 14–05212-EF-1. Rockville, MD: Agency for Healthcare Research and Quality. In., vol. 14–05212-EF-1; 2016.
4.
5.
6.
7.
US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, Curry SJ, Bauman L, Davidson KW, Epling JWJ, Garcia FA, Herzstein J, Kemper AR, et al. Screening for latent tuberculosis infection in adults: US preventive services task force recommendation statement. JAMA. 2016;316(9):962–9.CrossRef
8.
Sterling TR, Bethel J, Goldberg S, Weinfurter P, Yun L, Horsburgh CR, Tuberculosis Epidemiologic Studies C. The scope and impact of treatment of latent tuberculosis infection in the United States and Canada. Am J Respir Crit Care Med. 2006;173(8):927–31.CrossRefPubMed
9.
Ehman M, Flood J, Barry PM. Tuberculosis treatment managed by providers outside the public health department: lessons for the affordable care act. PLoS One. 2014;9(10):e110645.CrossRefPubMedPubMedCentral
10.
Institute of Medicine Committee on the Elimination of Tuberculosis in the United States. Ending neglect: the elimination of tuberculosis in the U.S. Washington (DC): national academy of sciences; 2000.
11.
Balaban V, Marks SM, Etkind SC, Katz DJ, Higashi J, Flood J, Cronin A, Ho CS, Khan A, Chorba T. Tuberculosis elimination efforts in the United States in the era of insurance expansion and the affordable care act. Public Health Rep. 2015;130(4):349–54.CrossRefPubMedPubMedCentral
12.
13.
14.
15.
Hirsch-Moverman Y, Daftary A, Franks J, Colson PW. Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada. The international journal of tuberculosis and lung disease. 12(11):1235–54.
16.
Stuurman AL, Noordegraaf-Schouten MV, Van Kessel F, Oordt-Speets A, Sandgren AA, Van der Werf MJ. Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review. BMC Infect Dis. 2016;16:257.CrossRefPubMedPubMedCentral
17.
Virnig BA, McBean M. Administrative data for public health surveillance and planning. Annu Rev Public Health. 2001;22(1):213–30.CrossRefPubMed
18.
19.
Stockbridge EL, Miller TL, Carlson EK, Ho CS. Tuberculosis prevention in the private sector: using claims-based methods to identify and evaluate latent tuberculosis infection treatment with isoniazid among the commercially insured. J Public Health Manag Pract. 2017. Epub Ahead of Print
20.
Horsburgh CR Jr, Goldberg S, Bethel J, Chen S, Colson PW, Hirsch-Moverman Y, Hughes S, Shrestha-Kuwahara R, Sterling TR, Wall K, et al. Latent TB infection treatment acceptance and completion in the United States and Canada. Chest. 2010;137(2):401–9.CrossRefPubMed
21.
22.
Comstock GW. How much isoniazid is needed for prevention of tuberculosis among immunocompetent adults? Int J Tuberc Lung Dis. 1999;3(10):847–50.PubMed
23.
24.
25.
26.
27.
Centers for Disease Control and Prevention. Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society. MMWR. 2000;49(RR-6):1–51.
28.
Williams R. Generalized ordered logit/partial proportional odds models for ordinal dependent variables. Stata J. 2006;6(1):58–82.
29.
Saltelli A, Tarantola S, Campolongo F, Ratto M. Sensitivity analysis in practice: A Guide to Assessing Scientific Methods. West Sussex, England: John Wiley & Sons Ltd; 2004.
30.
IBM Corporation: IBM SPSS modeler 17 algorithms guide. Chicago, IL: IBM software Group; 2015.
31.
StataCorp: Stata Statistical Software: Release 14. College Station, TX: StataCorp LP; 2016.
32.
Horgan CM, Merrick EL, Stewart MT, Scholle SH, Shih S. Improving medication management of depression in health plans. Psychiatr Serv. 2008;59(1):72–7.CrossRefPubMed
33.
Alexander BD, Broccolo BM, Daniels AR, SM DV, Hutto CB, Colborn-Loepere C, Matyas DE, Mayo TW, Miles JJ, Polikoff EA, et al. Fundamentals of Health Law, vol. 5th. Washington, DC: American Health Laywers Association; 2011.
34.
35.
36.
37.
Brown TA, Rickles NM. Mail-order versus local pharmacies on adherence: study methods make for unfair comparison. Am J Manag Care. 2010;16(3):226–7. author reply 227-228PubMed
38.
Sandgren AA, Noordegraaf-Schouten MV, van Kessel F, Stuurman A, Oordt-Speets A, van der Werf MJ. Initiation and completion rates for latent tuberculosis infection treatment: a systematic review. BMC Infect Dis. 2016;16(1):204.CrossRefPubMedPubMedCentral
39.
Sharma SK, Sharma A, Kadhiravan T, Tharyan P. Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB. Cochrane Database Syst Rev. 2013;7:Cd007545.
40.
Lewinsohn DM, Leonard MK, LoBue PA, et al. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis. 2017;64(2):e1-e33.CrossRefPubMed
41.
42.
Francke AL, Smit MC, de Veer AJE, Mistiaen P. Factors influencing the implementation of clinical guidelines for health care professionals: a systematic meta-review. BMC Medical Informatics and Decision Making. 2008;8(38)
43.
McKinlay JB, Link CL, Freund KM, Marceau LD, O’Donnell AB, Lutfey KL. Sources of variation in physician adherence with clinical guidelines: results from a factorial experiment. J Gen Intern Med. 2007;22(3):289–96.CrossRefPubMedPubMedCentral
44.
Oren E, Winston CA, Pratt R, Robison VA, Narita M. Epidemiology of urban tuberculosis in the United States, 2000-2007. Am J Public Health. 2011;101(7):1256–63.CrossRefPubMedPubMedCentral
45.
46.
47.
Li JJ. Adherence to treatment of latent tuberculosis infection in a clinical population in new York City. Int J Infect Dis. 2010;14(4):e292–7.CrossRefPubMed
48.
Nyamathi AM, Christiani A, Nahid P, Gregerson P, Leake B. A randomized controlled trial of two treatment programs for homeless adults with latent tuberculosis infection. Int J Tuberc Lung Dis. 2006;10(7):775–82.PubMed
49.
Fiske CT, Yan FX, Hirsch-Moverman Y, Sterling TR, Reichler MR. Risk factors for treatment default in close contacts with latent tuberculous infection. Int J Tuberc Lung Dis. 2014;18(4):421–7.CrossRefPubMedPubMedCentral
50.
Young KH, Ehman M, Reves R, Peterson BL, Khan A, Chorba TL, Jereb J. Tuberculosis contact investigations--United States, 2003-2012. MMWR Morb Mortal Wkly Rep. 2016;64(50–51):1369–74.CrossRefPubMed
51.
McGinnis B, Kauffman Y, Olson KL, Witt DM, Raebel MA. Interventions aimed at improving performance on medication adherence metrics. Int J Clin Pharm. 2014;36(1):20–5.CrossRefPubMed
52.
Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105–16.CrossRefPubMed
53.
54.
55.
56.
57.
Sueta CA, Rodgers JE, Chang PP, Zhou L, Thudium EM, Kucharska-Newton AM, Stearns SC. Medication adherence based on part D claims for patients with heart failure after hospitalization (from the atherosclerosis risk in communities study). Am J Cardiol. 2015;116(3):413–9.CrossRefPubMedPubMedCentral
58.
Seabury SA, Lakdawalla DN, Dougherty JS, Sullivan J, Goldman DP. Medication adherence and measures of health plan quality. Am J Manag Care. 2015;21(6):e379–89.PubMed
59.
Kirkman MS, Rowan-Martin MT, Levin R, Fonseca VA, Schmittdiel JA, Herman WH, Aubert RE. Determinants of adherence to diabetes medications: findings from a large pharmacy claims database. Diabetes Care. 2015;38(4):604–9.PubMedPubMedCentral
60.
Doshi JA, Lim R, Li P, Young PP, Lawnicki VF, Troxel AB, Volpp KG. Synchronized prescription refills and medication adherence: a retrospective claims analysis. Am J Manag Care. 2017;23(2):98–104.PubMed
61.
62.
Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;15(8):565–74. discussion 575-567CrossRefPubMed
Metadata
Title
Predictors of latent tuberculosis infection treatment completion in the US private sector: an analysis of administrative claims data
Authors
Erica L. Stockbridge
Thaddeus L. Miller
Erin K. Carlson
Christine Ho
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-5578-3

Other articles of this Issue 1/2018

BMC Public Health 1/2018 Go to the issue

Research article

Experiences of frontline nursing staff on workplace safety and occupational health hazards in two psychiatric hospitals in Ghana

Research article

A tailored within-community specimen collection strategy increased uptake of cervical cancer screening in a cross-sectional study in Ghana

Research article

Estimating the health consequences of flight attendant work: comparing flight attendant health to the general population in a cross-sectional study

Research article

Association between education and television viewing among older working and retired people: a comparative study of Finland and Japan

Research article

Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016

Research article

Effectiveness and cost-effectiveness of neuromuscular exercise and back care counseling in female healthcare workers with recurrent non-specific low back pain: a blinded four-arm randomized controlled trial